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Parasite-specific cyclic nucleotide phosphodiesterase inhibitors to target Neglected Parasitic Diseases

Objective

This project aims to unite global efforts to target the highly druggable class of enzymes called cyclic nucleotide phosphodiesterases (PDEs) in the fight for neglected parasitic diseases (NPD). It will establish a drug discovery platform, PDE4NPD, that combines phenotypic screening with efficient target-centric drug discovery, including target validation, various strategies for compound screening, PDE hit and lead optimization, safety and toxicology assessments and evaluation of anti-parasitic activity. The platform will make use of the target class expertise that the participating SMEs have gained when developing drugs for human and parasite PDEs, while all public partners offer proven experience in the field of NPD. The SMEs will adopt and progress existing PDE inhibitors that are in different stages of the drug discovery pipeline (i.e., target validation, hit and lead optimization). The current portfolio of inhibitors have clinical potential for treating sleeping sickness, Chagas' disease and leishmaniasis. Finding novel hits and leads for the PDEs that are associated with helminth diseases is also foreseen. The platform is open for targeting other NPD, and a broad panel of phenotypic screens (including malaria) is available to test PDE inhibitors. The phenotypic screening is performed by world-renowned groups, including two institutes in endemic countries. By capturing human and parasite PDE-related data in annotated chemogenomics databases, PDE-4-NPD will achieve the knowledge accumulation that is typical for target-centric approaches, thereby making the NPD drug development more efficient and enabling the SMEs to take advantage of the molecular understanding that is key for developing new medicines. The PDE4NPD platform constitutes an ideal basis for creating fruitful collaborations with both public and private partners word-wide.

Field of science

  • /natural sciences/computer and information sciences/databases
  • /medical and health sciences/health sciences/infectious disease/malaria
  • /natural sciences/biological sciences/genetics and heredity/nucleotide
  • /natural sciences/mathematics/pure mathematics/mathematical analysis/differential equations/partial differential equations
  • /medical and health sciences/basic medicine/toxicology
  • /medical and health sciences/clinical medicine/psychiatry/sleep disorders
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

STICHTING VU
Address
De Boelelaan 1105
1081 HV Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 215 666
Administrative Contact
Rob Leurs (Prof.)

Participants (10)

UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 786 759
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joe Galloway (Mr.)
IOTA Pharmaceuticals Ltd
United Kingdom
EU contribution
€ 545 156
Address
Cowley Road St Johns Innovation Centre
CB4 0WS Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Paul England (Dr.)
UNIVERSITY OF KENT
United Kingdom
EU contribution
€ 787 968
Address
The Registry Canterbury
CT2 7NZ Canterbury, Kent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrew Massoura (Dr.)
European ScreeningPort GmbH

Participation ended

Germany
EU contribution
€ 31 654,72
Address
Schnackenburgallee
22525 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sheraz Gul (Dr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 398 664
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Ana Maria De La Fuente (Ms.)
Theodor Bilharz Research Institute
Egypt
EU contribution
€ 299 938
Address
El Nil Street
12411 Giza
Activity type
Research Organisations
Administrative Contact
Amr Radwan (Dr.)
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 778 548
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Adams (Mrs.)
FUNDACAO OSWALDO CRUZ
Brazil
EU contribution
€ 199 419
Address
Avenida Brasil 4365
21040 900 Rio De Janeiro
Activity type
Research Organisations
Administrative Contact
Maria De Nazaré Correia Soeiro (Mrs.)
STICHTING LYGATURE
Netherlands
EU contribution
€ 300 000
Address
Jaarbeursplein 6
3521 AL Utrecht
Activity type
Other
Administrative Contact
Herman Verheij (Dr.)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 656 227,28
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
Administrative Contact
Michael Prestele (Mr.)