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Parasite-specific cyclic nucleotide phosphodiesterase inhibitors to target Neglected Parasitic Diseases

Ziel

This project aims to unite global efforts to target the highly druggable class of enzymes called cyclic nucleotide phosphodiesterases (PDEs) in the fight for neglected parasitic diseases (NPD). It will establish a drug discovery platform, PDE4NPD, that combines phenotypic screening with efficient target-centric drug discovery, including target validation, various strategies for compound screening, PDE hit and lead optimization, safety and toxicology assessments and evaluation of anti-parasitic activity. The platform will make use of the target class expertise that the participating SMEs have gained when developing drugs for human and parasite PDEs, while all public partners offer proven experience in the field of NPD. The SMEs will adopt and progress existing PDE inhibitors that are in different stages of the drug discovery pipeline (i.e. target validation, hit and lead optimization). The current portfolio of inhibitors have clinical potential for treating sleeping sickness, Chagas' disease and leishmaniasis. Finding novel hits and leads for the PDEs that are associated with helminth diseases is also foreseen. The platform is open for targeting other NPD, and a broad panel of phenotypic screens (including malaria) is available to test PDE inhibitors. The phenotypic screening is performed by world-renowned groups, including two institutes in endemic countries. By capturing human and parasite PDE-related data in annotated chemogenomics databases, PDE-4-NPD will achieve the knowledge accumulation that is typical for target-centric approaches, thereby making the NPD drug development more efficient and enabling the SMEs to take advantage of the molecular understanding that is key for developing new medicines. The PDE4NPD platform constitutes an ideal basis for creating fruitful collaborations with both public and private partners word-wide.

Aufforderung zur Vorschlagseinreichung

FP7-HEALTH-2013-INNOVATION-1
Andere Projekte für diesen Aufruf anzeigen

Koordinator

STICHTING VU
Adresse
De Boelelaan 1105
1081 HV Amsterdam
Niederlande

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Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Rob Leurs (Prof.)
EU-Beitrag
€ 1 215 666

Beteiligte (10)

UNIVERSITY OF GLASGOW
United Kingdom
EU-Beitrag
€ 786 759
Adresse
University Avenue
G12 8QQ Glasgow

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Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Joe Galloway (Mr.)
IOTA Pharmaceuticals Ltd
United Kingdom
EU-Beitrag
€ 545 156
Adresse
Cowley Road St Johns Innovation Centre
CB4 0WS Cambridge

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Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Paul England (Dr.)
UNIVERSITY OF KENT
United Kingdom
EU-Beitrag
€ 787 968
Adresse
The Registry Canterbury
CT2 7NZ Canterbury, Kent

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Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Andrew Massoura (Dr.)
European ScreeningPort GmbH

Beteiligung beendet

Deutschland
EU-Beitrag
€ 31 654,72
Adresse
Schnackenburgallee
22525 Hamburg

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Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Sheraz Gul (Dr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spanien
EU-Beitrag
€ 398 664
Adresse
Calle Serrano 117
28006 Madrid

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Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Ana Maria De La Fuente (Ms.)
Theodor Bilharz Research Institute
Ägypten
EU-Beitrag
€ 299 938
Adresse
El Nil Street
12411 Giza

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Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Amr Radwan (Dr.)
UNIVERSITEIT ANTWERPEN
Belgien
EU-Beitrag
€ 778 548
Adresse
Prinsstraat 13
2000 Antwerpen

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Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Anne Adams (Mrs.)
FUNDACAO OSWALDO CRUZ
Brasilien
EU-Beitrag
€ 199 419
Adresse
Avenida Brasil 4365
21040 900 Rio De Janeiro

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Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Maria De Nazaré Correia Soeiro (Mrs.)
STICHTING LYGATURE
Niederlande
EU-Beitrag
€ 300 000
Adresse
Jaarbeursplein 6
3521 AL Utrecht

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Aktivitätstyp
Other
Kontakt Verwaltung
Herman Verheij (Dr.)
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Deutschland
EU-Beitrag
€ 656 227,28
Adresse
Hansastrasse 27c
80686 Munchen

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Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Michael Prestele (Mr.)