Skip to main content

MULTISCALE APPROACH TO THE IDENTIFICATION OF MOLECULAR BIOMARKERS IN ACUTE HEART FAILURE INDUCED BY SHOCK

Objective

The management of cardiovascular stability in shock patients is of paramount importance in critical care. New, cutting edge knowledge is necessary to overcome the shortcomings of available therapies, in order to cope with the challenges that anesthesiologists, intensive care specialists and emergency physicians face when dealing with shock patients.
Current therapies are targeted to reduce symptoms of shock and multiple organ failure, but they are unable to target the root cause or to act at the “beginning of the cascade”, because of the lack of a model explaining the molecular basis of shock induced tissue injury and ensuing multiple organ failure. Hence, the effectiveness of anti-hypotensive interventions such as fluid resuscitation is limited. Fluid may restore blood pressure within minutes, but complications such as pulmonary edema may arise on a longer time scale in patients who are unresponsive to fluid infusion, and cause more severe stress to the patient’s hemodynamic stability, respiratory efficiency, and immune system.
This proposal seeks to shed light on the molecular trigger of acute heart failure in association to shock, in the presence of uncontrolled proteolytic activity, in order to identify inflammatory mediators and markers which are activated in shock, through a systematic analysis of expression levels of genes and their protein products, and novel targets for the delivery of new therapies, necessary to overcome the limitations of current ones.

Field of science

  • /medical and health sciences/basic medicine/immunology
  • /medical and health sciences/clinical medicine/critical care medicine

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

POLITECNICO DI MILANO
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 865 801,31
Administrative Contact
Fabio Conti (Dr.)

Participants (10)

FILARETE SERVIZI SRL
Italy
EU contribution
€ 810 179,83
Address
Viale Ortles 22/4
20139 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Barbara Martini (Dr.)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 482 365,66
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
Administrative Contact
Maria Grazia Pezzoni (Ms.)
NEURO-ZONE SRL
Italy
EU contribution
€ 475 731,98
Address
Via Ludovico Ariosto 21
20091 Bresso
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Valentina Cartareggia (Dr.)
CUSTOM SOFTWARE & ELECTRONICS SL
Spain
EU contribution
€ 788 614,94
Address
C/marie Curie Sn - Parc Tec Barna N
08042 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ramon Domenech (Dr.)
MUTUA DE TERRASSA MUTUALITAT DE PREVISIO SOCIAL A PRIMA FIXA
Spain
EU contribution
€ 51 856,85
Address
Plaza Dr Robert 5
08221 Terrassa
Activity type
Other
Administrative Contact
Laura Buguñá Hoffmann (Ms.)
FUNDACIO PARC CIENTIFIC DE BARCELONA
Spain
EU contribution
€ 391 626,87
Address
Baldiri I Reixac 4
08028 Barcelona
Activity type
Research Organisations
Administrative Contact
Moises Tarte (Mr.)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 469 219,66
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Enzo Fancello (Mr.)
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 266 912,15
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christine Courillon (Dr.)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
EU contribution
€ 282 705
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cortlandt Urquhart (Mr.)
ANTLIA SA
Switzerland
EU contribution
€ 288 986,75
Address
Parc Scientifique Epfl Pse C Eclublens Pse
1015 Lausanne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nikolaos Stergiopulos (Prof.)