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Neuropathic pain: biomarkers and druggable targets within the endogenous analgesia system

Ziel

Neuropathic pain has a high incidence in Europe and often affects the patient’s emotional balance and quality of life. Recent meta-analyses have shown that conventional analgesic drugs are not sufficiently effective in these patients and are limited by serious side effects. The search for new analgesics is extremely difficult despite identification of several new potential targets and enormous investment by the pharmaceutical industry. Important reasons for this failure are the poor predictive validity of currently available animal models of chronic pain, that do not simulate multidimensional clinical pain, and the high inter-individual variability of neuropathic pain manifestations and treatment responses. We will overcome these obstacles by an interdisciplinary collaboration between basic science groups, clinicians and leading private companies. This consortium will validate new animal models to evaluate the electrophysiological, behavioural, emotional and cognitive manifestations of neuropathic pain and the effectiveness of novel compounds. The use of these models in combination with other behavioural paradigms and new conditional knockout mouse lines for specific components of the endogenous opioid and cannabinoid system will permit the identification of novel druggable targets and biomarkers for neuropathic pain. Novel analgesic compounds acting on these endogenous systems developed by the private companies of the consortium will be tested in these new paradigms. Clinical studies will identify novel biomarkers for neuropathic pain using powerful genetics approaches and investigate treatment effectiveness with a translational focus based on cross validation of the findings in animals and humans.

Aufforderung zur Vorschlagseinreichung

FP7-HEALTH-2013-INNOVATION-1
Andere Projekte für diesen Aufruf anzeigen

Koordinator

UNIVERSIDAD POMPEU FABRA
Adresse
Placa De La Merce, 10-12
08002 Barcelona
Spanien
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 928 000
Kontakt Verwaltung
Eva Martin (Ms.)

Beteiligte (10)

UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU-Beitrag
€ 545 040
Adresse
Gower Street
WC1E 6BT London
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Gosia Kielbasa (Ms.)
GW PHARMA LIMITED
United Kingdom
EU-Beitrag
€ 454 999,89
Adresse
Porton Down Science Park
SP4 0QJ Salisbury
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Stephen Wright (Dr.)
ESTEVE PHARMACEUTICALS, SA
Spanien
EU-Beitrag
€ 206 000,03
Adresse
Passeig De La Zona Franca 109, 4A Planta
08038 Barcelona
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
José Miguel Vela (Dr.)
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
Frankreich
EU-Beitrag
€ 500 800
Adresse
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Steve Brooks (Dr.)
UNIVERSITATSKLINIKUM BONN
Deutschland
EU-Beitrag
€ 499 800
Adresse
Venusberg-campus 1
53127 Bonn
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Beate Becker
INSTYTUT FARMAKOLOGII POLSKIEJ AKADEMII NAUK
Polen
EU-Beitrag
€ 455 000
Adresse
Smetna 12
31-343 Krakow
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Lidia Radwan (Ms.)
ISLENSK ERFDAGREINING EHF
Island
EU-Beitrag
€ 846 937
Adresse
Sturlugotu 8
101 Reykjavik
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Frosti Jonsson (Mr.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Deutschland
EU-Beitrag
€ 653 400,04
Adresse
Chariteplatz 1
10117 Berlin
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Eveline Fräßdorf (Ms.)
HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ
Finnland
EU-Beitrag
€ 500 600,04
Adresse
Stenbackinkatu 9
00029 Helsinki
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Alexander Andresen (Mr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU-Beitrag
€ 402 000
Adresse
South Kensington Campus Exhibition Road
SW7 2AZ London
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Tatjana Palalic (Ms.)