Objectif The goal of SYMPATH is to advance clinical development of therapeutic vaccines targeting α-synuclein (aSyn)-driven neurodegenerative diseases (ND). It addresses Parkinson’s disease (PD) and multiple system atrophy (MSA), two synucleopathies, for which no causal therapy exists. Ultimately, both lead to patient disability and death, which along with patient number (PD) and age of onset (MSA, PD) define their high medical need status.The proposed programme focuses on 2 vaccine candidates, PD01A and PD03A, delivered by the innovative AFFITOME® technology. Both are peptide-protein conjugate vaccines and first-in-class candidates. They were selected to elicit antibodies neutralizing aSyn but sparing compensatory β-synuclein. Pre-clinical evaluation confirmed their disease-modifying activity in various models. The unprecedented clinical approach, called TANDEM strategy, uses the synergy resulting from applying 2 vaccine candidates in 2 complementary indications linked through their pathology. TANDEM PD/MSA capitalizes on (i) excellent clinical research centres and their associated national/European networks, (ii) platform methods assessing aSyn species as candidate biomarkers and (iii) preliminary clinical experience with PD01A, the first aSyn targeting vaccine ever tested in humans. Its core is formed by 2 phase I studies testing PD01A in MSA and PD03A in PD/MSA. Importantly, trial design (duration, endpoints, vaccine dose and schedule) will ensure collection of initial biomarker data connecting clinical results of PD- and MSA trajectories. SYMPATH defines the logical next development step of both AFFITOPE® vaccine candidates for synucleopathies and generates information/material (biobank) rendering them more amenable to rational drug development. Successful completion of the programme promises reaching aSyn pathology with an active vaccine as a causal therapy for PD/MSA, thus advancing one or both candidates as prime targets for product development and investment. Champ scientifique natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesbasic medicinepathologymedical and health sciencesbasic medicineneurologyparkinson Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH.2013.1.3-3 - Safety and efficacy of therapeutic vaccines Appel à propositions FP7-HEALTH-2013-INNOVATION-1 Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur AFFIRIS AG Contribution de l’UE € 2 905 925,00 Adresse KARL FARKAS GASSE 22 1030 Wien Autriche Voir sur la carte Région Ostösterreich Wien Wien Contact administratif Vera Bürger (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (7) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire BIOLUTION GMBH Autriche Contribution de l’UE € 685 011,00 Adresse HELMUT QUALTINGER GASSE 2/2 1030 Wien Voir sur la carte Région Ostösterreich Wien Wien Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Iris Grünert (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CHU HOPITAUX DE BORDEAUX France Contribution de l’UE € 342 712,00 Adresse RUE DUBERNAT 12 33404 Talence Voir sur la carte Région Nouvelle-Aquitaine Aquitaine Gironde Type d’activité Higher or Secondary Education Establishments Contact administratif Jean-Jacques Jalibert (Mr.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Contribution de l’UE € 173 503,00 Adresse RUE DE TOLBIAC 101 75654 Paris Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Muriel Bouas (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée PROSENEX AMBULATORIUM BETRIEBSGMBH Autriche Contribution de l’UE € 366 012,00 Adresse Schottenfeldgasse 45 1070 Wien Voir sur la carte Région Ostösterreich Wien Wien Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Dieter Volc (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée MEDIZINISCHE UNIVERSITAT INNSBRUCK Autriche Contribution de l’UE € 366 012,00 Adresse CHRISTOPH PROBST PLATZ 1 6020 Innsbruck Voir sur la carte Région Westösterreich Tirol Innsbruck Type d’activité Higher or Secondary Education Establishments Contact administratif Wolfram Rieneck (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée FORSCHUNGSZENTRUM JULICH GMBH Allemagne Contribution de l’UE € 789 322,00 Adresse WILHELM JOHNEN STRASSE 52428 Julich Voir sur la carte Région Nordrhein-Westfalen Köln Düren Type d’activité Research Organisations Contact administratif Anke Krüger (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE France Contribution de l’UE € 371 209,00 Adresse RUE VIGUERIE 2 HOTEL DIEU SAINT JACQUES 31052 Toulouse Cedex 3 Voir sur la carte Région Occitanie Midi-Pyrénées Haute-Garonne Type d’activité Higher or Secondary Education Establishments Contact administratif Corinne Joffre (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
