Skip to main content

Reach α-synuclein-dependent neurodegeneration: clinical development of therapeutic AFFITOPE vaccines for Parkinson’s disease and multisystem atrophy

Objectif

The goal of SYMPATH is to advance clinical development of therapeutic vaccines targeting α-synuclein (aSyn)-driven neurodegenerative diseases (ND). It addresses Parkinson’s disease (PD) and multiple system atrophy (MSA), two synucleopathies, for which no causal therapy exists. Ultimately, both lead to patient disability and death, which along with patient number (PD) and age of onset (MSA, PD) define their high medical need status.
The proposed programme focuses on 2 vaccine candidates, PD01A and PD03A, delivered by the innovative AFFITOME® technology. Both are peptide-protein conjugate vaccines and first-in-class candidates. They were selected to elicit antibodies neutralizing aSyn but sparing compensatory β-synuclein. Pre-clinical evaluation confirmed their disease-modifying activity in various models. The unprecedented clinical approach, called TANDEM strategy, uses the synergy resulting from applying 2 vaccine candidates in 2 complementary indications linked through their pathology. TANDEM PD/MSA capitalizes on (i) excellent clinical research centres and their associated national/European networks, (ii) platform methods assessing aSyn species as candidate biomarkers and (iii) preliminary clinical experience with PD01A, the first aSyn targeting vaccine ever tested in humans. Its core is formed by 2 phase I studies testing PD01A in MSA and PD03A in PD/MSA. Importantly, trial design (duration, endpoints, vaccine dose and schedule) will ensure collection of initial biomarker data connecting clinical results of PD- and MSA trajectories. SYMPATH defines the logical next development step of both AFFITOPE® vaccine candidates for synucleopathies and generates information/material (biobank) rendering them more amenable to rational drug development. Successful completion of the programme promises reaching aSyn pathology with an active vaccine as a causal therapy for PD/MSA, thus advancing one or both candidates as prime targets for product development and investment.

Appel à propositions

FP7-HEALTH-2013-INNOVATION-1
Voir d’autres projets de cet appel

Coordinateur

AFFIRIS AG
Adresse
Karl Farkas Gasse 22
1030 Wien
Autriche

Voir sur la carte

Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Vera Bürger (Mrs.)
Contribution de l’UE
€ 2 905 925

Participants (7)

BIOLUTION GMBH
Autriche
Contribution de l’UE
€ 685 011
Adresse
Helmut Qualtinger Gasse 2/2
1030 Wien

Voir sur la carte

Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Iris Grünert (Dr.)
CHU HOPITAUX DE BORDEAUX
France
Contribution de l’UE
€ 342 712
Adresse
Rue Dubernat 12
33404 Talence

Voir sur la carte

Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Jean-Jacques Jalibert (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Contribution de l’UE
€ 173 503
Adresse
Rue De Tolbiac 101
75654 Paris

Voir sur la carte

Type d’activité
Research Organisations
Contact administratif
Muriel Bouas (Mrs.)
PROSENEX AMBULATORIUM BETRIEBSGMBH
Autriche
Contribution de l’UE
€ 366 012
Adresse
Schottenfeldgasse 45
1070 Wien

Voir sur la carte

Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Dieter Volc (Dr.)
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Autriche
Contribution de l’UE
€ 366 012
Adresse
Christoph Probst Platz 1
6020 Innsbruck

Voir sur la carte

Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Wolfram Rieneck (Dr.)
FORSCHUNGSZENTRUM JULICH GMBH
Allemagne
Contribution de l’UE
€ 789 322
Adresse
Wilhelm Johnen Strasse
52428 Julich

Voir sur la carte

Type d’activité
Research Organisations
Contact administratif
Anke Krüger (Mrs.)
CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
France
Contribution de l’UE
€ 371 209
Adresse
Rue Viguerie 2 Hotel Dieu Saint Jacques
31052 Toulouse Cedex 3

Voir sur la carte

Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Corinne Joffre (Dr.)