Objective Approximately 42% of infants’ mortality in the world is related to congenital heart defects (prevalence: 8-12/1000 births). Over 1/3 require the reconstruction of the right ventricular outflow tract (RVOT) by surgical procedures which currently use inert materials without any growth potential. Consequently, multiple reoperations are often required, with their attendant high risk of mortality and morbidity.The TEH-TUBE project will address these limitations by creating a novel bioabsorbable biomaterial using a polymeric valved tube either seeded with autologous adipose tissue derived stem cells (ADSC) or functionalized by a peptidic sequence triggering homing of the host cells onto the scaffold to make it a living self-populated structure. During the project we will:• Compare a number of polymers, including but not limited to polydioxanone, polyhydroxyalkanoate, and poly-ester-urethane-ureas, processed by electrospinning to generate a competent valved tube• Compare, in the selected polymer, different methods of functionalisation using in vitro mechanical and biological tests as well as in vivo animal experiments (primarily rats)• Validate the ultimate combination (polymer + functionalisation technique) in a clinically relevant large animal model (in this case, the growing lamb to specifically assess the regenerative and growth potential of the composite construct)This stepwise approach will be conducted within a tightly controlled regulatory framework to ensure that the final product meets the current ATMP requirements for phase I/II clinical studies and, if successful, ultimate commercialization.Our TEH-TUBE project aims at developing an innovative biomaterial for the treatment of congenital heart abnormalities in children and young adults. By creating a material whose growth will keep pace with that of the patient, this product, geared to become an ATMP, should decrease the risk of reoperative surgeries, improve the quality of life and ultimately have a positive impact on healthcare costs. Fields of science social sciencessociologydemographymortalitymedical and health sciencesmedical biotechnologytissue engineeringnatural scienceschemical sciencespolymer sciencesmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicinesurgerysurgical procedures Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2013.2.2-1 - Biomaterials for Advanced Therapies and Medical Devices in the neurological/neuromuscular or cardiovascular fields Call for proposal FP7-NMP-2013-SME-7 See other projects for this call Funding Scheme CP-TP - Collaborative Project targeted to a special group (such as SMEs) Coordinator ASSISTANCE PUBLIQUE HOPITAUX DE PARIS EU contribution € 765 880,00 Address 55 BOULEVARD DIDEROT 75012 Paris France See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Estelle Ziegler (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all STATICE SAS France EU contribution € 794 902,00 Address RUE THOMAS EDISON 9 25000 Besancon See on map Region Bourgogne-Franche-Comté Franche-Comté Doubs Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anne Legain (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data RESCOLL France EU contribution € 676 860,00 Address ALLEE GEOFFROY SAINT HILAIRE 8 CS 30021 33600 Pessac See on map Region Nouvelle-Aquitaine Aquitaine Gironde Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Konstantin Sipos (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CELYAD Belgium EU contribution € 893 060,00 Address RUE EDOUARD BELIN 12 1435 MONT SAINT GUIBERT See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Aymeric Seron (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON EU contribution € 368 466,00 Address GOWER STREET WC1E 6BT LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Kamila Kolasinska (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HELMHOLTZ-ZENTRUM HEREON GMBH Germany EU contribution € 748 034,00 Address MAX PLANCK STRASSE 1 21502 Geesthacht See on map Region Schleswig-Holstein Schleswig-Holstein Herzogtum Lauenburg Activity type Research Organisations Administrative Contact Hans-Jörg Isemer (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EURAM LIMITED United Kingdom EU contribution € 253 760,00 Address LUCY TOWER STREET TOWER HOUSE LN1 1XW Lincoln See on map Region East Midlands (England) Lincolnshire Lincolnshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Andrew Banasik (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data