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Nanotherapeutics for antibiotic resistant emerging bacterial pathogens

Objective

Increase in antibiotic resistance is a global concern worldwide. The project NAREB's main objective is the optimization of several nanoformulations of antibacterial therapeutics in order to improve the therapy of multi-drug resistant (MDR) tuberculosis (TB) and MRSA infections in European MDR patients.

NAREB will address the problem of drug bioavailability inside the infected macrophages, transport across the bacterial cell wall, and avoidance of escape mechanisms (expressed by the pathogen). The success of the utilization of nanoparticles in the improvement of drug targeting in other diseases opens the way for novel applications in nanotechnology-based treatments aimed at controlling MDR-TB and MRSA.

Specific objectives to achieve the main goal are:
(i) Screening of different combinations of antibiotic drugs (small chemical molecules and/or biomacromolecules - glycopeptides) with nanocarriers (lipid, polymeric, biopolymeric);
(ii) Loading of Transcription Factor Decoys (TFDs) designed to block the expression of essential bacterial genes in compatible nanoparticle systems and their testing as novel antibacterials;
(iii) In vitro and in vivo testing of the best therapeutic combinations in relevant experimental models and using innovative bioimaging;
(iv) Improved formulations of multifunctional particles containing selected antibiotics and TFDs for increasing the bioavailability of active molecules in the site of infection (targeting strategy, adapted route of administration)
(v) Assessing safety, regulatory and production (GLP/GMP) aspects in relation with the most promising nanoformulations;
(vi) Clinical Development Plan for the preparatory work for the subsequent clinical testing of the selected nanoformulations.

The project NAREB brings together 15 partners (including 4 SMEs and 1 industry) from 8 EU Member and Associated States with outstanding complementary expertise, ranging from material engineering to molecular biology, pharmacology and medicine.

Field of science

  • /natural sciences/biological sciences/microbiology/bacteriology
  • /natural sciences/biological sciences/molecular biology
  • /natural sciences/physical sciences/theoretical physics/particles
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/multidrug resistance
  • /social sciences/social and economic geography/transport
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance
  • /medical and health sciences/basic medicine/pharmacology and pharmacy

Call for proposal

FP7-NMP-2013-LARGE-7
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

INSTITUT PASTEUR
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
France
Activity type
Research Organisations
EU contribution
€ 1 576 873,80
Administrative Contact
Sophie Ablott

Participants (15)

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 968 521
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Véronique Chavanon (Ms.)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 370 802
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin De Geest (Mr.)
PROCARTA BIOSYSTEMS LIMITED

Participation ended

United Kingdom
EU contribution
€ 344 065
Address
Bankside 300 Peachman Way
NR7 0LB Norwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Mcarthur (Dr.)
UNIVERSIDAD DE ZARAGOZA
Spain
EU contribution
€ 765 614
Address
Calle Pedro Cerbuna 12
50009 Zaragoza
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Oscar Lopez Lorente (Mr.)
National Medicines Institute (Narodowy Instytut Lekow)
Poland
EU contribution
€ 213 262
Address
Chelmska
00-725 Warsaw
Activity type
Research Organisations
Administrative Contact
Renata Cellmer (Ms.)
FORSCHUNGSZENTRUM BORSTEL
Germany
EU contribution
€ 363 466
Address
Parkallee 1-40
23845 Borstel
Activity type
Research Organisations
Administrative Contact
Sandra Von Pein (Ms.)
BIOASTER FONDATION DE COOPERATION SCIENTIFIQUE
France
EU contribution
€ 858 776,20
Address
40 Avenue Tony Garnier
69007 Lyon
Activity type
Research Organisations
Administrative Contact
Pascale Boissel (Mrs.)
Medicines and Healthcare products Regulatory Agency
United Kingdom
EU contribution
€ 79 849
Address
Buckingham Palace Road
SW1W 9SZ London
Activity type
Research Organisations
Administrative Contact
Amanda King (Mrs.)
GLAXOSMITHKLINE INVESTIGACION Y DESARROLLO SL
Spain
EU contribution
€ 810 480
Address
C/ Severo Ochoa Numero 2 Parque Tecnologico De Madrid
28760 Tres Cantos
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Francisco Rubio (Dr.)
CORIS BIOCONCEPT SPRL
Belgium
EU contribution
€ 512 824
Address
Rue Jean Sonet 4A Parc Scientifique Crealys Les Isnes
5032 Gembloux
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thierry Leclipteux (Dr.)
NANOIMMUNOTECH SL
Spain
EU contribution
€ 1 019 702
Address
Edificio Citexvi C Fonte Das Abelle Sn Campus Universitario De Vigo
36310 Vigo Pontevedra
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ruben Santos Martínez De Laguna (Mr.)
STIFTELSEN SINTEF
Norway
EU contribution
€ 845 282
Address
Strindveien 4
7034 Trondheim
Activity type
Research Organisations
Administrative Contact
Tove Lillian Hønstad (Mrs.)
INSERM TRANSFERT SA
France
EU contribution
€ 479 044
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Louis Jammayrac (Mr.)
KUECEPT LIMITED
United Kingdom
EU contribution
€ 227 528
Address
Station Close 16-17
EN6 1TL Potters Bar Herts
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bryn Williams (Mr.)
UNIVERSITY OF EAST ANGLIA
United Kingdom
EU contribution
€ 238 069
Address
Earlham Road
NR4 7TJ Norwich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yvonne Kirkham (Mrs.)