Objective Increase in antibiotic resistance is a global concern worldwide. The project NAREB's main objective is the optimization of several nanoformulations of antibacterial therapeutics in order to improve the therapy of multi-drug resistant (MDR) tuberculosis (TB) and MRSA infections in European MDR patients.NAREB will address the problem of drug bioavailability inside the infected macrophages, transport across the bacterial cell wall, and avoidance of escape mechanisms (expressed by the pathogen). The success of the utilization of nanoparticles in the improvement of drug targeting in other diseases opens the way for novel applications in nanotechnology-based treatments aimed at controlling MDR-TB and MRSA.Specific objectives to achieve the main goal are:(i) Screening of different combinations of antibiotic drugs (small chemical molecules and/or biomacromolecules - glycopeptides) with nanocarriers (lipid, polymeric, biopolymeric);(ii) Loading of Transcription Factor Decoys (TFDs) designed to block the expression of essential bacterial genes in compatible nanoparticle systems and their testing as novel antibacterials;(iii) In vitro and in vivo testing of the best therapeutic combinations in relevant experimental models and using innovative bioimaging;(iv) Improved formulations of multifunctional particles containing selected antibiotics and TFDs for increasing the bioavailability of active molecules in the site of infection (targeting strategy, adapted route of administration)(v) Assessing safety, regulatory and production (GLP/GMP) aspects in relation with the most promising nanoformulations;(vi) Clinical Development Plan for the preparatory work for the subsequent clinical testing of the selected nanoformulations.The project NAREB brings together 15 partners (including 4 SMEs and 1 industry) from 8 EU Member and Associated States with outstanding complementary expertise, ranging from material engineering to molecular biology, pharmacology and medicine. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsengineering and technologynanotechnologynano-materialsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistancemedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2013.1.2-2 - Nanotherapeutics to treat bacterial infectious diseases Call for proposal FP7-NMP-2013-LARGE-7 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator INSTITUT PASTEUR Address Rue du docteur roux 25-28 75724 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Sophie Ablott Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 576 873,80 Participants (15) Sort alphabetically Sort by EU Contribution Expand all Collapse all COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France EU contribution € 968 521,00 Address Rue leblanc 25 75015 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Véronique Chavanon (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITEIT UTRECHT Netherlands EU contribution € 370 802,00 Address Heidelberglaan 8 3584 CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Martin De Geest (Mr.) Links Contact the organisation Opens in new window Website Opens in new window PROCARTA BIOSYSTEMS LIMITED Participation ended United Kingdom EU contribution € 344 065,00 Address Bankside 300 peachman way NR7 0LB Norwich See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael Mcarthur (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSIDAD DE ZARAGOZA Spain EU contribution € 765 614,00 Address Calle pedro cerbuna 12 50009 Zaragoza See on map Region Noreste Aragón Zaragoza Activity type Higher or Secondary Education Establishments Administrative Contact Oscar Lopez Lorente (Mr.) Links Contact the organisation Opens in new window Website Opens in new window NARODOWY INSTYTUT LEKOW Poland EU contribution € 213 262,00 Address Ulica chelmska 30/34 00 725 Warszawa See on map Region Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa Activity type Research Organisations Administrative Contact Renata Cellmer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window FORSCHUNGSZENTRUM BORSTEL LEIBNIZ LUNGENZENTRUM Germany EU contribution € 363 466,00 Address Parkallee 1-40 23845 Borstel See on map Region Schleswig-Holstein Schleswig-Holstein Segeberg Activity type Research Organisations Administrative Contact Sandra Von Pein (Ms.) Links Contact the organisation Opens in new window Website Opens in new window BIOASTER FONDATION DE COOPERATION SCIENTIFIQUE France EU contribution € 858 776,20 Address 40 avenue tony garnier 69007 Lyon See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Research Organisations Administrative Contact Pascale Boissel (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Medicines and Healthcare products Regulatory Agency United Kingdom EU contribution € 79 849,00 Address Buckingham palace road SW1W 9SZ London See on map Administrative Contact Amanda King (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window GLAXOSMITHKLINE INVESTIGACION Y DESARROLLO SL Spain EU contribution € 810 480,00 Address C/ severo ochoa numero 2 parque tecnologico de mad 28760 Tres cantos madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Francisco Rubio (Dr.) Links Contact the organisation Opens in new window Website Opens in new window CORIS BIOCONCEPT SPRL Belgium EU contribution € 512 824,00 Address Rue guillaume fouquet 11 5032 Gembloux See on map Region Région wallonne Prov. Namur Arr. Namur Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Thierry Leclipteux (Dr.) Links Contact the organisation Opens in new window Website Opens in new window NANOIMMUNOTECH SL Spain EU contribution € 1 019 702,00 Address Edificio citexvi c fonte das abelle sn campus universitario de vigo 36310 Vigo pontevedra See on map Region Noroeste Galicia Pontevedra Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ruben Santos Martínez De Laguna (Mr.) Links Contact the organisation Opens in new window Website Opens in new window STIFTELSEN SINTEF Norway EU contribution € 845 282,00 Address Strindveien 4 7034 Trondheim See on map Region Norge Trøndelag Trøndelag Activity type Research Organisations Administrative Contact Tove Lillian Hønstad (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window INSERM TRANSFERT SA France EU contribution € 479 044,00 Address 10 rue d'oradour-sur-glane - parisante campus 75015 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Louis Jammayrac (Mr.) Links Contact the organisation Opens in new window Website Opens in new window KUECEPT LIMITED United Kingdom EU contribution € 227 528,00 Address Station close 16-17 EN6 1TL Potters bar herts See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bryn Williams (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITY OF EAST ANGLIA United Kingdom EU contribution € 238 069,00 Address Earlham road NR4 7TJ Norwich See on map Region East of England East Anglia Norwich and East Norfolk Activity type Higher or Secondary Education Establishments Administrative Contact Yvonne Kirkham (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window
