Objective
A hallmark of profound understanding of the organization of a living cell is the ability to reconstitute essential cellular functionalities from minimal components. To achieve this breakthrough a concerted effort of cell biology, biochemistry and biophysics is required. Our project brings together this expertise to reconstitute the cell’s ability to control the organization of cytoskeletal networks in an artificial ‘Model’ Cell.
To achieve a mechanistic understanding of how cell organization is regulated, we will develop methods to manipulate cytoskeletal interactions in space and time and study the effects of such manipulation on functional cytoskeletal organization in the confinement of both artificial systems and cells. We will focus on regulatory interactions at dynamic microtubule plus ends, which play an essential role in cell division, polarization, and migration. Using a combination of in vitro, in vivo, and theoretical approaches, we aim at the following goals:
1. Achieve a molecular scale understanding of cooperative and competitive relationships between regulators at microtubule ends, and their effect on microtubule dynamics, microtubule behavior at the cell boundary, and interactions with actin filaments.
2. Generate a quantitative understanding of symmetric and polarized positioning of the microtubule cytoskeleton by microtubule-cell boundary interactions during cell division and cell migration.
3. Obtain a mechanistic view of microtubule-actin co-organization driven by regulatory effects at microtubule ends, with and without the additional contribution of microtubule-cell boundary interactions, and apply this knowledge to manipulate cell polarization and migration.
Synergy between our complementary expertise, tools, infrastructure and local collaboration networks is key to achieving these goals. Our groups are located within short travel distance from each other, allowing the coupling of infrastructure and resources on a daily basis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- natural sciences biological sciences cell biology cell polarity
- natural sciences biological sciences biophysics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2013-SyG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
2628 CN DELFT
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.