Obiettivo "X-ray crystallography yields atomic-resolution 3D images of the whole spectrum of molecules ranging from small inorganic clusters to large protein complexes constituting the macromolecular machinery of life. Life is not static, and many of the most important reactions in chemistry and biology are light induced and occur on ultrafast timescales. These have been studied with high time resolution primarily by ultrafast laser spectroscopy, but they reduce the vast complexity of the process to a few reaction coordinates. Here we develop attosecond serial crystallography and spectroscopy, to give a full description of ultrafast processes atomically resolved in real space and on the electronic energy landscape, from co-measurement of X-ray and optical spectra, and X-ray diffraction. This technique will revolutionize our understanding of structure and function at the atomic and molecular level and thereby unravel fundamental processes in chemistry and biology. We apply a fully coherent attosecond X-ray source based on coherent inverse Compton scattering off a free-electron crystal, developed in this project, to outrun radiation damage effects due to the necessary high X-ray irradiance required to acquire diffraction signals [A. Cho, ""Breakthrough of the year"", Science 388, 1530 (2012)]. Our synergistic project will optimize the entire instrumentation towards fundamental measurements of the mechanism of light absorption and excitation energy transfer. The multidisciplinary team optimizes X-ray pulse parameters, in tandem with sample delivery, crystal size, and advanced X-ray detectors. We will apply our new capabilities to one of the most important problems in structural biology, which is to elucidate the dynamics of light reactions, electron transfer and protein structure in photosynthesis. Also, the attosecond source can provide a coherent seed and will help to overcome peak flux limitations of X-ray FELs by introducing chirped pulse amplification to FEL technology." Campo scientifico scienze naturaliscienze della terra e scienze ambientali connessegeologiamineralogiacristallografiascienze naturaliscienze biologichebiochimicabiomolecoleproteinescienze naturaliscienze fisicheotticafisica dei laserlaser ultravelociscienze naturaliscienze biologichebiologia molecolarebiologia strutturalescienze naturaliscienze fisicheotticaspettroscopia Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-2013-SyG - ERC Synergy Grant Invito a presentare proposte ERC-2013-SyG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-SyG - Synergy grant Primo ricercatore principale Franz Xaver Kaertner Prof. Coordinatore DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY Indirizzo Notkestrasse 85 22607 Hamburg Germania Mostra sulla mappa Regione Hamburg Hamburg Hamburg Tipo di attività Research Organisations Contatto amministrativo Ute Krell (Dr.) Ricercatore principale Franz Xaver Kaertner (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Contributo UE Nessun dato Beneficiari (2) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY Germania Contributo UE € 10 774 200,00 Indirizzo Notkestrasse 85 22607 Hamburg Mostra sulla mappa Regione Hamburg Hamburg Hamburg Tipo di attività Research Organisations Contatto amministrativo Ute Krell (Dr.) Ricercatore principale Franz Xaver Kaertner (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Altri finanziamenti Nessun dato UNIVERSITAET HAMBURG Germania Contributo UE € 3 110 000,00 Indirizzo Mittelweg 177 20148 Hamburg Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Simone Ludwig (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Altri finanziamenti Nessun dato