Objetivo The HELMHOLTZ project associates two leading neighbouring institutions: the Institut de la Vision (Fondation Voir et Entendre) and the Institut Langevin (Fondation Pierre-Gilles de Gennes) committed to boost the integration of technological research in photonics, acoustics and ultrasound with translational research on vision impairment, in order to co-develop and validate prototypes for non-invasive in vivo structural and functional dynamic imaging technologies for ophthalmology.Innovative imaging tools will rely on emerging concepts such as ultrafast ultrasound, laser Doppler holography, full field and ultrafast cell resolution optical coherence tomography (OCT), bi-photon microscopy. These will enable both structural and functional analyses of the ocular tissues, with strong focus on the macula, the central part of the retina which is affected by the most severe disabling conditions, e.g. retinal dystrophies, age-related macular degeneration, glaucoma, vascular diseases, diabetic retinopathy, toxicities. We shall explore: 1) the subcellular and dynamic structure of photoreceptors, 2) changes in vascular flow and 3) functional imaging of the visual system from retina to cortex. Massive data acquisition and ultrafast numerical signal processing will take advantage of GPU-based parallel computing and of new asynchronous visual sensors. Continuous feedbacks from animal and human studies will lead to refine or redefine the prototypes jointly.These new diagnostic tools will address unmet medical needs by improving the understanding of retinal pathophysiology, defining new biomarkers for disease progressions and enabling clinicians to select the best suited emerging therapies, from neuroprotection to gene therapy and visual restoration. As the most optically and functionally approachable part of the brain, the retina will thus exemplify and validate major streams of technological innovations for care by enhancing cross-fertilization between biomedicine and physics. Ámbito científico medical and health sciencesclinical medicineophthalmologyglaucomamedical and health sciencesclinical medicineangiologyvascular diseasesmedical and health sciencesmedical biotechnologygenetic engineeringgene therapymedical and health sciencesclinical medicineophthalmologyretinopathynatural sciencesphysical sciencesacousticsultrasound Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-2013-SyG - ERC Synergy Grant Convocatoria de propuestas ERC-2013-SyG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-SyG - Synergy grant Investigador principal de referencia José-Alain Sahel Prof. Institución de acogida FONDATION DE COOPERATION SCIENTIFIQUE VOIR ET ENTENDRE Aportación de la UE € 5 973 523,00 Dirección 17 RUE MOREAU 75012 Paris Francia Ver en el mapa Región Ile-de-France Ile-de-France Val-de-Marne Tipo de actividad Research Organisations Contacto administrativo Stéphane Duhieu (Mr.) Investigador principal Alexandre, Mathias Fink (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo FONDATION DE COOPERATION SCIENTIFIQUE VOIR ET ENTENDRE Francia Aportación de la UE € 5 973 523,00 Dirección 17 RUE MOREAU 75012 Paris Ver en el mapa Región Ile-de-France Ile-de-France Val-de-Marne Tipo de actividad Research Organisations Contacto administrativo Stéphane Duhieu (Mr.) Investigador principal Alexandre, Mathias Fink (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS Francia Aportación de la UE € 5 888 400,00 Dirección RUE VAUQUELIN 10 75231 Paris Ver en el mapa Región Ile-de-France Ile-de-France Paris Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Jean-Baptiste Hennequin (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos