Objective Worldwide figures show that there were 160,000 incidences of melanoma in 2002, whilst 39,000 died from the disease. These upward trends are worrying, as malignant melanoma is one of the most difficult cancers to treat, due to its ability to spread quickly and its resistance to standard chemotherapeutic agents. In order to counteract this trend, targeted therapies that inhibit melanoma metastasis are required. The aim of SYS-MEL is to identify and validate prognostic and predictive biomarkers for melanoma, and to model the predictive value of these biomarkers in determining the efficacy of melanoma therapies. The central objective is to bring together four European academic institutes and two SMEs to develop 3 prognostic/predictive biomarker assays for melanoma. 3 core areas of interest are epigenetics, signalling pathways in melanoma and systems biological approaches for predicting chemotherapy responses. SYS-MEL will have three main elements: 1) Epigenomic and protein expression analysis of melanoma tissue, to validate an epigenomic signature initially identified in the FP7-funded programme Target-Melanoma; 2) In silico modelling and prediction of patient responses to decarbazine DTIC using both in vitro analysis of apoptotic pathways and a novel systems biology approach, incorporating mathematical systems modelling, quantitative biochemistry and cell biology; 3) Investigating the components of the P-Rex1 pathway that are involved in driving the migration of melanoblast cells, and thus the progression of metastasis, incorporating a computational system tailored to model complex signalling pathways. This approach will enable us to identify prognostic and predictive biomarkers for melanoma, and to develop a powerful computational modeling approach to predict disease progression and patient responses to treatment. Fields of science medical and health sciencesclinical medicineoncologyskin cancermelanomanatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencescell biologynatural sciencesbiological sciencesgeneticsepigenetics Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Call for proposal FP7-PEOPLE-2013-IAPP See other projects for this call Funding Scheme MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Coordinator UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN EU contribution € 427 227,16 Address BELFIELD 4 Dublin Ireland See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Administrative Contact Donal Doolan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 155 485,00 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Monique Vanhaeren (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ROYAL COLLEGE OF SURGEONS IN IRELAND Participation ended Ireland EU contribution € 46 982,93 Address ST STEPHEN'S GREEN 123 2 Dublin See on map Region Ireland Northern and Western Border Activity type Higher or Secondary Education Establishments Administrative Contact Markus Rehm (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BEATSON INSTITUTE FOR CANCER RESEARCH LBG United Kingdom EU contribution € 128 164,96 Address SWITCHBACK ROAD GARSCUBE ESTATE G61 1BD Bearsden See on map Region Scotland West Central Scotland East Dunbartonshire Activity type Research Organisations Administrative Contact Owen Sansom (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ONCOMARK LIMITED Ireland EU contribution € 737 861,11 Address 172 RATHGAR ROAD RATHGAR Dublin 6 DUBLIN See on map Region Ireland Eastern and Midland Dublin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Stephen Penney (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PATHOLOGY DIAGNOSTICS LTD Participation ended United Kingdom EU contribution € 200 383,48 Address COWLEY ROAD ST JOHN S INNOVATION CB4 0WS CAMBRIDGE CAMBRIDGESHIRE See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Vivian Bolton (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF STUTTGART Germany EU contribution € 117 895,36 Address KEPLERSTRASSE 7 70174 Stuttgart See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Markus Rehm (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
