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A pipeline for the discovery, sustainable production and commercial utilisation of known and novel high-value triterpenes with new or superior biological activities

Objective

Mankind is continually screening low-molecular-weight compounds from a plethora of synthetic and natural sources in the search for molecules with novel or superior pharmaceutical, agrochemical or other biological activities. In this regard, plants are a potentially rich source of bioactive molecules. Because of their extreme diversity and complex chemistry, however, plant metabolism is still underexplored. Consequently, the full potential of plant-derived, low-molecular weight, bioactive compounds is still largely untapped.
The TriForC consortium will tackle this issue by establishing an integrative and innovative pipeline for the exploitation of plant triterpenes, one of the largest classes of plant bioactive compounds with an astonishing array of structural diversity and spectrum of biological activities. The TriForC partners each bring to the consortium the necessary tools, resources, methods and production systems required to assemble the pipeline and produce high value plant bioactives for commercialisation for use as e.g. new drugs or agrochemicals.
The TriForC consortia will identify new bioactive triterpenes from natural resources by exploring biodiversity. To increase diversity and bioactivity, new-to-nature triterpenes will be derived by semi-synthesis and by an elaborate metabolic engineering platform in plant and microalgal bioreactor-based production systems. To unleash the potential of triterpenes for green biotechnology, structure-activity relationships for triterpenoids will be explored via high throughput screenings for novel chemical entities with potential agrochemical and pharmacological applications. TriForC will further develop and upscale plant-based bioreactors for sustainable commercial production and bio-refining of high-value triterpenes. The TriForC project will guarantee a sustainable and industrially exploitable supply of high value plant compounds with new or superior biological activities ready for commercialisation.

Call for proposal

FP7-KBBE-2013-7-single-stage
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Coordinator

KOBENHAVNS UNIVERSITET
Address
Norregade 10
1165 Kobenhavn
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 270 960
Administrative Contact
Søren Bak (Prof.)

Participants (10)

ALKION BIOPHARMA SAS
France
EU contribution
€ 650 720
Address
Rue Pierre Fontaine 4
91000 Evry
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Franck Michoux (Dr.)
SPICER CONSULTING LIMITED
United Kingdom
EU contribution
€ 778 440
Address
Eden Laboratory - Broadmead Road
MK43 9ND Stewartby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andrew Spicer (Dr.)
VIVACELL BIOTECHNOLOGY ESPANA SL
Spain
EU contribution
€ 590 181
Address
Calle Astronoma Cecilia Payne S/n Planta 1 - Edificio Centauro - Parque Cientifico Tecnologico De Cordoba 21
14014 Cordoba
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Maria De La Luz Bellido (Dr.)
STOCKTON ISRAEL LTD
Israel
EU contribution
€ 658 640
Address
Hamefalsim 17
49134 Petach Tikva
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ido Korman (Mr.)
EXTRASYNTHESE SAS
France
EU contribution
€ 362 880
Address
Impasse Jacquard Zi Lyon Nord
69730 Genay
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marie Claude Djeffal (Ms.)
VIB VZW
Belgium
EU contribution
€ 660 817
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Rik Audenaert (Mr.)
JOHN INNES CENTRE
United Kingdom
EU contribution
€ 705 097
Address
Norwich Research Park Colney
NR4 7UH Norwich
Activity type
Research Organisations
Administrative Contact
Mary Anderson (Dr.)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 481 520
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italy
EU contribution
€ 322 640
Address
Duomo 6
13100 Vercelli
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carlo Muzio (Dr.)
PANEPISTIMIO THESSALIAS
Greece
EU contribution
€ 400 160
Address
Argonafton Filellinon
38221 Volos
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dimitrios Messalouris (Mr.)