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A pipeline for the discovery, sustainable production and commercial utilisation of known and novel high-value triterpenes with new or superior biological activities

Cel

Mankind is continually screening low-molecular-weight compounds from a plethora of synthetic and natural sources in the search for molecules with novel or superior pharmaceutical, agrochemical or other biological activities. In this regard, plants are a potentially rich source of bioactive molecules. Because of their extreme diversity and complex chemistry, however, plant metabolism is still underexplored. Consequently, the full potential of plant-derived, low-molecular weight, bioactive compounds is still largely untapped.
The TriForC consortium will tackle this issue by establishing an integrative and innovative pipeline for the exploitation of plant triterpenes, one of the largest classes of plant bioactive compounds with an astonishing array of structural diversity and spectrum of biological activities. The TriForC partners each bring to the consortium the necessary tools, resources, methods and production systems required to assemble the pipeline and produce high value plant bioactives for commercialisation for use as e.g. new drugs or agrochemicals.
The TriForC consortia will identify new bioactive triterpenes from natural resources by exploring biodiversity. To increase diversity and bioactivity, new-to-nature triterpenes will be derived by semi-synthesis and by an elaborate metabolic engineering platform in plant and microalgal bioreactor-based production systems. To unleash the potential of triterpenes for green biotechnology, structure-activity relationships for triterpenoids will be explored via high throughput screenings for novel chemical entities with potential agrochemical and pharmacological applications. TriForC will further develop and upscale plant-based bioreactors for sustainable commercial production and bio-refining of high-value triterpenes. The TriForC project will guarantee a sustainable and industrially exploitable supply of high value plant compounds with new or superior biological activities ready for commercialisation.

Zaproszenie do składania wniosków

FP7-KBBE-2013-7-single-stage
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Koordynator

KOBENHAVNS UNIVERSITET
Adres
Norregade 10
1165 Kobenhavn
Dania

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Søren Bak (Prof.)
Wkład UE
€ 1 270 960

Uczestnicy (10)

ALKION BIOPHARMA SAS
Francja
Wkład UE
€ 650 720
Adres
Rue Pierre Fontaine 4
91000 Evry

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Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Franck Michoux (Dr.)
SPICER CONSULTING LIMITED
United Kingdom
Wkład UE
€ 778 440
Adres
Eden Laboratory - Broadmead Road
MK43 9ND Stewartby

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Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Andrew Spicer (Dr.)
VIVACELL BIOTECHNOLOGY ESPANA SL
Hiszpania
Wkład UE
€ 590 181
Adres
Calle Astronoma Cecilia Payne S/n Planta 1 - Edificio Centauro - Parque Cientifico Tecnologico De Cordoba 21
14014 Cordoba

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Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Maria De La Luz Bellido (Dr.)
STOCKTON ISRAEL LTD
Izrael
Wkład UE
€ 658 640
Adres
Hamefalsim 17
49134 Petach Tikva

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Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Ido Korman (Mr.)
EXTRASYNTHESE SAS
Francja
Wkład UE
€ 362 880
Adres
Impasse Jacquard Zi Lyon Nord
69730 Genay

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Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Marie Claude Djeffal (Ms.)
VIB VZW
Belgia
Wkład UE
€ 660 817
Adres
Rijvisschestraat 120
9052 Zwijnaarde - Gent

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Rodzaj działalności
Research Organisations
Kontakt administracyjny
Rik Audenaert (Mr.)
JOHN INNES CENTRE
United Kingdom
Wkład UE
€ 705 097
Adres
Norwich Research Park Colney
NR4 7UH Norwich

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Rodzaj działalności
Research Organisations
Kontakt administracyjny
Mary Anderson (Dr.)
WEIZMANN INSTITUTE OF SCIENCE
Izrael
Wkład UE
€ 481 520
Adres
Herzl Street 234
7610001 Rehovot

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Talia Tzahor (Ms.)
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Włochy
Wkład UE
€ 322 640
Adres
Duomo 6
13100 Vercelli

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Carlo Muzio (Dr.)
PANEPISTIMIO THESSALIAS
Grecja
Wkład UE
€ 400 160
Adres
Argonafton Filellinon
38221 Volos

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Dimitrios Messalouris (Mr.)