Skip to main content

A pipeline for the discovery, sustainable production and commercial utilisation of known and novel high-value triterpenes with new or superior biological activities

Objetivo

Mankind is continually screening low-molecular-weight compounds from a plethora of synthetic and natural sources in the search for molecules with novel or superior pharmaceutical, agrochemical or other biological activities. In this regard, plants are a potentially rich source of bioactive molecules. Because of their extreme diversity and complex chemistry, however, plant metabolism is still underexplored. Consequently, the full potential of plant-derived, low-molecular weight, bioactive compounds is still largely untapped.
The TriForC consortium will tackle this issue by establishing an integrative and innovative pipeline for the exploitation of plant triterpenes, one of the largest classes of plant bioactive compounds with an astonishing array of structural diversity and spectrum of biological activities. The TriForC partners each bring to the consortium the necessary tools, resources, methods and production systems required to assemble the pipeline and produce high value plant bioactives for commercialisation for use as e.g. new drugs or agrochemicals.
The TriForC consortia will identify new bioactive triterpenes from natural resources by exploring biodiversity. To increase diversity and bioactivity, new-to-nature triterpenes will be derived by semi-synthesis and by an elaborate metabolic engineering platform in plant and microalgal bioreactor-based production systems. To unleash the potential of triterpenes for green biotechnology, structure-activity relationships for triterpenoids will be explored via high throughput screenings for novel chemical entities with potential agrochemical and pharmacological applications. TriForC will further develop and upscale plant-based bioreactors for sustainable commercial production and bio-refining of high-value triterpenes. The TriForC project will guarantee a sustainable and industrially exploitable supply of high value plant compounds with new or superior biological activities ready for commercialisation.

Ámbito científico

  • /ingeniería y tecnología/biotecnología industrial/ingeniería metabólica

Convocatoria de propuestas

FP7-KBBE-2013-7-single-stage
Consulte otros proyectos de esta convocatoria

Régimen de financiación

CP-TP - Collaborative Project targeted to a special group (such as SMEs)

Coordinador

KOBENHAVNS UNIVERSITET
Dirección
Norregade 10
1165 Kobenhavn
Dinamarca
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 1 270 960
Contacto administrativo
Søren Bak (Prof.)

Participantes (10)

ALKION BIOPHARMA SAS
Francia
Aportación de la UE
€ 650 720
Dirección
Rue Pierre Fontaine 4
91000 Evry
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Franck Michoux (Dr.)
SPICER CONSULTING LIMITED
United Kingdom
Aportación de la UE
€ 778 440
Dirección
Eden Laboratory - Broadmead Road
MK43 9ND Stewartby
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Andrew Spicer (Dr.)
VIVACELL BIOTECHNOLOGY ESPANA SL
España
Aportación de la UE
€ 590 181
Dirección
Calle Astronoma Cecilia Payne S/n Planta 1 - Edificio Centauro - Parque Cientifico Tecnologico De Cordoba 21
14014 Cordoba
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Maria De La Luz Bellido (Dr.)
STOCKTON ISRAEL LTD
Israel
Aportación de la UE
€ 658 640
Dirección
Hamefalsim 17
49134 Petach Tikva
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Ido Korman (Mr.)
EXTRASYNTHESE SAS
Francia
Aportación de la UE
€ 362 880
Dirección
Impasse Jacquard Zi Lyon Nord
69730 Genay
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Marie Claude Djeffal (Ms.)
VIB VZW
Bélgica
Aportación de la UE
€ 660 817
Dirección
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Tipo de actividad
Research Organisations
Contacto administrativo
Rik Audenaert (Mr.)
JOHN INNES CENTRE
United Kingdom
Aportación de la UE
€ 705 097
Dirección
Norwich Research Park Colney
NR4 7UH Norwich
Tipo de actividad
Research Organisations
Contacto administrativo
Mary Anderson (Dr.)
WEIZMANN INSTITUTE OF SCIENCE
Israel
Aportación de la UE
€ 481 520
Dirección
Herzl Street 234
7610001 Rehovot
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Talia Tzahor (Ms.)
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italia
Aportación de la UE
€ 322 640
Dirección
Duomo 6
13100 Vercelli
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Carlo Muzio (Dr.)
PANEPISTIMIO THESSALIAS
Greece
Aportación de la UE
€ 400 160
Dirección
Argonafton Filellinon
38221 Volos
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Dimitrios Messalouris (Mr.)