Objetivo
Emerging evidence indicates that the gut microbiome contributes to our ability to extract energy from the diet and influences development and function of the immune, endocrine and nervous systems, which regulate energy balance and behaviour. This has led to hypothesize that developing microbiome-based dietary interventions can be cost-effective measures to prevent diet-related and behavioural disorders. Yet this approach is restricted in practice by a lack of understanding of the specific species that contribute to these disorders and their interactions with host and lifestyle determinants. To progress beyond the state of the art, the MyNewGut proposal aims to: (1) shed light on the contribution of the human microbiome to nutrient metabolism and energy expenditure; (2) identify microbiome-related features that contribute to or predict obesity and associated disorders in human epidemiological studies; (3) understand how the microbiome is influenced by environmental factors and its role in brain and immune development and function in humans; and (4) provide proof-of-concept of the disease risk-reduction potential of dietary intervention with new foods/ingredients targeting the gut microbiome in humans. To this end, a translational multidisciplinary research strategy will be developed, combining experts in omic-technologies and all other scientific disciplines required. Consequently, the MyNewGut proposal will contribute to developing new approaches to prevent diet-related diseases (metabolic syndrome and obesity) and behavioural disorders through lifestyle changes, intake of pro- and prebiotics and semi-personalised and innovative food products. This will ultimately contribute to increasing the competitiveness of the European food industry and provide consumers with reliable claims on foods. Results will also help inform new strategies on public health, support EU legislation and improve the position of the EU in the field of food-related disease prevention.
Ámbito científico
Not validated
Not validated
Convocatoria de propuestas
FP7-KBBE-2013-7-single-stage
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Régimen de financiación
CP-IP - Large-scale integrating projectCoordinador
28006 Madrid
España
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Participantes (32)
40126 Bologna
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T12 YN60 Cork
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1165 Kobenhavn
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75007 Paris
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1348 Louvain La Neuve
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80333 Muenchen
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2595 DA Den Haag
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1105AZ Amsterdam
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93053 Regensburg
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RG6 6AH Reading
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8010 Graz
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28359 Bremen
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18071 Granada
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21000 Novi Sad
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1040 BRUXELLES
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6708 PW Wageningen
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1010 Wien
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59482 HAUBOURDIN
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43122 Parma
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31700 Blagnac
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33119 SIERO
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N/A Cork
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3524 KW UTRECHT
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SUBOTICA
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2601 Acton Act
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77030 Houston Tx
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46109 1274 Ann Arbor
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1010 Auckland
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K7L 3N6 Kingston
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4072 Brisbane
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1800 Vilvoorde
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4103 WR CULEMBORG
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