Final Report Summary - MECHCOMM (Mechanotransduction in Cell-to-Cell Communication)
We developed methods to control and measure the spatial organization of membrane proteins with nanoscale resolution using DNA nanotechnology. Ligand/DNA nanostructures with well-defined spatial configurations were added to live cells and we analysed how these signals were interpreted by cells. We found that the nano-organization of ligands impacted the activation of membrane receptors and ensuing intracellular responses and cellular functions in cancer and immune cells. Our findings can provide a scientific basis for the design of future nanotechnology-based biological drugs.