Identifying Inflammatory Bowel Disease causative genes through trans-eQTLs mapping within GWAS loci

Projektinformationen

TRANS_CEDAR

ID Finanzhilfevereinbarung: 624639

Abgeschlossenes Projekt

Startdatum 1 März 2014

Enddatum 29 Februar 2016

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 169 800,00

EU-Beitrag € 169 800,00

Koordiniert durch

UNIVERSITE DE LIEGE
Belgium

Ziel

Life-time prevalence of inflammatory bowel disease (IBD) is reaching an alarming rate of > 1/400 in industrialized societies. Improved understanding of disease pathogenesis is essential to develop more effective preventive, diagnostic and therapeutic measures. Genome-wide association studies (GWAS) have identified ~ 160 risk loci contributing to inherited predisposition to Crohn's disease and/or ulcerative colitis. While this has already led to the identification of new perturbed pathways and potential drug targets, causative genes and variants remain unknown for the vast majority of risk loci. Moreover, the identified risk loci only account for an estimated 25% of inherited risk. GWAS loci are likely to be regulatory and therefore alter expression levels of other genes. In the present project we propose to apply an integrated genomic and transcriptomic approach to identify novel genes and pathways that are causally involved in inherited prediposition to IBD. We aim to detect causative genes implicated in IBD’s susceptibility through the evaluation of trans-eQTLs within GWAS loci. Trans_CEDAR is based on the generation of an integrated dataset of nine cell/tissue types collected on 350 healthy caucasians individuals, as well as on the use of next generation sequencing to identify rare variants in functionally-incriminated candidate genes. We expect to detect new causative variants that may constitute new drug targets. The present project will also generate a map of trans-eQTL in different tissues, equally useful for the study of other diseases, to be shared with the scientific community.

Wissenschaftliches Gebiet

• medical and health sciences › clinical medicine › gastroenterology › inflammatory bowel disease

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2013-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

UNIVERSITE DE LIEGE

Kontakt Verwaltung

Michel Georges (Prof.)

• EU-Beitrag: € 169 800,00
• Adresse: PLACE DU 20 AOUT 7 ; 4000 Liege ; Belgien
• Region: Région wallonne › Prov. Liège › Arr. Liège
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten