Integrated study of skin resident Memory T cells and dermal mononuclear phagocytes in the fight against PATHogens

Informations projet

METAPATH

N° de convention de subvention: 625328

Projet clôturé

Date de début 2 Septembre 2014

Date de fin 1 Septembre 2016

Financé au titre de

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coût total € 253 450,90

Contribution de l’UE € 253 450,90

Coordonné par

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Objectif

"""Integrated study of skin resident Memory T cells and dermal mononuclear phagocytes in the fight against PATHogens""

Control of pathogen infection requires the generation of a tightly regulated immune response that recognizes the invading pathogen and that limits a potentially harmful host response. Recent work highlighted that resident memory T cells (TRM) form a very potent means of establishing effective immunity against infection. In the skin, I contributed to the extensive characterization of mononuclear phagocytes and unveiled the phenotype and some of the functions of the dermal macrophage subsets as well as the different dendritic cell subsets. In the present proposal, I propose to study the role of those different antigen presenting cells in the generation of TRM cells in the dermis upon a first pathogen encounter and their role in the re-activation of those TRM cells upon a second encounter with the pathogen. Learning the mechanisms by which efficient TRM cells are generated in the dermis will be an important step in the design of rational approaches to achieve the appropriate control of the pathogen at the site of infection."

Champ scientifique (EuroSciVoc)

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• sciences médicales et de la santé › médecine fondamentale › immunologie

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thème(s)

• FP7-PEOPLE-2013-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development"

Appel à propositions

FP7-PEOPLE-2013-IOF
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Régime de financement

MC-IOF -

Coordinateur

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

• Contribution de l’UE: € 253 450,90
• Adresse: RUE DE TOLBIAC 101 ; 75654 Paris ; France
• Région: Ile-de-France › Ile-de-France › Paris
• Type d’activité: Organismes de recherche
• Coût total: Aucune donnée