Objectif There has been extensive research dedicated to identifying predictive biomarkers of tumor sensitivity to ligand-based therapies. Although some biomarkers have emerged, there is still no comprehensive understanding that unifies the observed tumor cell type-specific behaviors, in particular the differential responses to anti-cancer drugs.The collective realization is that no single protein measurement is predictive of therapeutic outcome. Large-scale studies focusing on multiple genetic biomarkers may be partially inadequate given the observed fractional killing of genetically-identical clonal cell populations.The objective of this proposal is to address this deficiency by coupling high-content analyses (dynamic live cell imaging, high-throughput assays) with theoretical and computational methods to provide a global understanding of the origins of tumor cell heterogeneity in response to anti-cancer drugs that target the apoptotic signaling pathway at the receptor level. Ultimately this approach will serve to identify, on a tumor cell type basis, the most predictive set of biomarkers and design optimal therapeutic combinations. Champ scientifique medical and health sciencesclinical medicineoncologylung cancernatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancenatural sciencescomputer and information sciencescomputational science Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2013-IIF - Marie Curie Action: "International Incoming Fellowships" Appel à propositions FP7-PEOPLE-2013-IIF Voir d’autres projets de cet appel Régime de financement MC-IIF - International Incoming Fellowships (IIF) Coordinateur CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Contribution de l’UE € 269 743,80 Adresse RUE MICHEL ANGE 3 75794 Paris France Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Sophie Deschaintres (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
