Objective
Viral morphogenesis, the phenomenon by which viruses reorganize their internal macromolecular structure in space and time across their lifecycle, is a complex process that is not quantitatively understood. HIV maturation, in particular, involves detailed atomistic processes such as protein-ligand recognition and cleavage that triggers large-scale macromolecular spatiotemporal rearrangement such as capsid self-assembly and RNA-modulated nucleocapsid condensation leading to infectious virus particles (virions) in a sequence of morphological changes that need to be carefully timed. Many antiretroviral inhibitors have been developed to stop maturation but their efficacy has been undermined by the emergence of drug resistant mutations. Furthermore, the effect of such inhibitors on the internal spatiotemporal viral dynamics is unknown. In order to quantitatively understand the determinants of maturation, inhibition and mutational resistance it is vital to construct a complete physics-based model of the maturation process. This requires detailed understanding of how all the relevant viral molecular constituents interact with each other at the atomistic level, how this is affected by drug interactions and mutations in proteins and how this carries over to the large-scale cleavage and self-assembly process. This project aims at deriving a multi-scale computer model of HIV maturation, integrating thermodynamic and kinetic binding data from massively parallel detailed molecular dynamics simulations of viral protein-protein and protein-drug interactions with particle-based reaction diffusion kinetics simulations describing the internal processing and remodeling in an entire virion explicitly in space and time. We will also investigate what happens if the morphological sequence is perturbed and use this to discover novel allosteric targets followed by implementing a high-throughput virtual and experimentally validated drug-screening program towards HIV eradication therapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- natural sciences biological sciences genetics mutation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
14195 BERLIN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.