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High-throughput real-time characterisation of cell-mechanical properties

Objective

We aim to commercialise a new, patent-protected concept to measure mechanical properties of biological cells with flow-cytometer-level throughput and establish its standard application in modern drug development and medical diagnostics. Mechanical properties have recently proven to be a physiologically relevant indicator to determine the state, function and type of biological cells. Analysing mechanical parameters provides a novel method to identify physiological or pathological changes. However, mechanical cell properties are currently not accessible for large-scale applications demanding high-throughput. We developed, designed and realised a hydrodynamic cell stretcher, a microfluidic-based device for analysing mechanical cell properties at rates above 100 cells per second and therefore three orders of magnitude faster than other existing methods. In the proposed project, we want to identify, test and validate the most promising applications of hydrodynamic cell stretching in clinical and pharmaceutical research.

Call for proposal

ERC-2013-PoC
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Funding Scheme

CSA-SA(POC) - Supporting action (Proof of Concept)

Host institution

TECHNISCHE UNIVERSITAET DRESDEN
Address
Helmholtzstrasse 10
01069 Dresden
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 149 549,84
Administrative Contact
Friederieke Noack (Mrs.)

Beneficiaries (1)

TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 149 549,84
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Friederieke Noack (Mrs.)