Validating C. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Project website

Project website with public and (secure) consortium partition

Two compound patents filed

Two patents filed on plant extracts or compounds prolonging healthspan

Press release

D8.1: Press releases (M1 at occasion of kick-off, and upon major discoveries)

C. elegans reporter strains

Report and publication(s) on validated set of C. elegans reporter strains with reporters for all known healthspan pathways to permit quick assessment of candidate treatments

Compounds affecting healthspan in mice

Reports and publications on compounds affecting healthspan in mice

Book published

Book published in Springer series Health Ageing and Longevity M60

Mechanism of action

Reports and publications on compounds with molecular mechanism demonstrated to be similar in C. elegans and human cells

Validated healthspan polymorphisms

Report of validated polymorphisms predictive of better (or worse) health in the aged, stratified by sex and gender, and mapped onto pathways

Sex and gender dependency

Reports and publications on dependency on sex and gender of healthspan effects

Healthspan compounds

Reports and publications on compounds that prolong healthspan in C. elegans, and their mechanism of action

Non-pharmacological C. elegans models

Report and publication(s) on models for non-pharmacological treatments in C. elegans

Preparations with activity in mammalian cells

Report and submitted publication on individual compounds and complex extracts with health-promoting activity in relevant mammalian cellular assay.

Publications

Trehalose administration in C57BL/6N old mice affects healthspan improving motor learning and brain anti-oxidant defences in a sex-dependent fashion: a pilot study

Author(s): Alessandra Berry, Matteo Marconi, Chiara Musillo, Flavia Chiarotti, Veronica Bellisario, Paola Matarrese, Lucrezia Gambardella, Rosa Vona, Maria Lombardi, Chiara Foglieni, Francesca Cirulli
Published in: Experimental Gerontology, Issue 129, 2020, Page(s) 110755, ISSN 0531-5565
Publisher: Elsevier BV
DOI: 10.1016/j.exger.2019.110755

Search for Early Pancreatic Cancer Blood Biomarkers in Five European Prospective Population Biobanks Using Metabolomics

Author(s): Jesse Fest, Lisanne S Vijfhuizen, Jelle J Goeman, Olga Veth, Anni Joensuu, Markus Perola, Satu Männistö, Eivind Ness-Jensen, Kristian Hveem, Toomas Haller, Neeme Tonisson, Kairit Mikkel, Andres Metspalu, Cornelia M van Duijn, Arfan Ikram, Bruno H Stricker, Rikje Ruiter, Casper H J van Eijck, Gert-Jan B van Ommen, Peter A C ʼt Hoen
Published in: Endocrinology, Issue 160/7, 2019, Page(s) 1731-1742, ISSN 1945-7170
Publisher: Oxford University Press
DOI: 10.1210/en.2019-00165

Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids

Author(s): Steffen Möller, Nadine Saul, Alan A. Cohen, Rüdiger Köhling, Sina Sender, Hugo Murua Escobar, Christian Junghanss, Francesca Cirulli, Alessandra Berry, Peter Antal, Priit Adler, Jaak Vilo, Michele Boiani, Ludger Jansen, Dirk Repsilber, Hans Jörgen Grabe, Stephan Struckmann, Israel Barrantes, Mohamed Hamed, Brecht Wouters, Liliane Schoofs, Walter Luyten, Georg Fuellen
Published in: Aging, Issue 12/13, 2020, Page(s) 12534-12581, ISSN 1945-4589
Publisher: Impact Journals, LLC
DOI: 10.18632/aging.103514

Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation

Author(s): Fei Yan, Qi Zhao, Huanpeng Gao, Xiaomei Wang, Ke Xu, Yishu Wang, Fuguo Han, Qingfei Liu, Yun Shi
Published in: Bioscience Reports, Issue 41/2, 2021, ISSN 0144-8463
Publisher: Kluwer Academic Publishers
DOI: 10.1042/bsr20203955

Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A.

Author(s): Leonid Rozanov; Meenakshi Ravichandran; Giovanna Grigolon; Maria Clara Zanellati; Johannes Mansfeld; Kim Zarse; Nir Barzilai; Gil Atzmon; Gil Atzmon; Fabian Fischer; Michael Ristow
Published in: Redox Biology, Issue 3, 2020, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.3929/ethz-b-000406666

Dynamic changes in p66Shc mRNA expression in peripheral blood mononuclear cells following resistance training intervention in old frail women born to obese mothers: a pilot study

Author(s): Alessandra Berry, Marco Bucci, Carla Raggi, Johan G. Eriksson, Maria Angela Guzzardi, Pirjo Nuutila, Ville Huovinen, Patricia Iozzo, Francesca Cirulli
Published in: Aging Clinical and Experimental Research, Issue 30/7, 2018, Page(s) 871-876, ISSN 1720-8319
Publisher: Springer Verlag
DOI: 10.1007/s40520-017-0834-4

Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice

Author(s): Gesine Reichart, Johannes Mayer, Cindy Zehm, Timo Kirschstein, Tursonjan Tokay, Falko Lange, Simone Baltrusch, Markus Tiedge, Georg Fuellen, Saleh Ibrahim, Rüdiger Köhling
Published in: Acta Physiologica, Issue 225/4, 2018, Page(s) e13214, ISSN 1748-1708
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/apha.13214

Phytochemicals Rosmarinic Acid, Ampelopsin, and Amorfrutin-A Can Modulate Age-Related Phenotype of Serially Passaged Human Skin Fibroblasts in vitro

Author(s): Lakshman Sodagam, Anna Lewinska, Ewa Kwasniewicz, Sofiya Kokhanovska, Maciej Wnuk, Karsten Siems, Suresh I. S. Rattan
Published in: Frontiers in Genetics, Issue 10, 2019, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2019.00081

Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways

Author(s): Georg Fuellen, Ludger Jansen, Alan A Cohen, Walter Luyten, Manfred Gogol, Andreas Simm, Nadine Saul, Francesca Cirulli, Alessandra Berry, Peter Antal, Rüdiger Köhling, Brecht Wouters, Steffen Möller
Published in: Aging and disease, Issue 10/4, 2019, Page(s) 883, ISSN 2152-5250
Publisher: International Society on Aging and Disease
DOI: 10.14336/ad.2018.1030

Suppression of the TGF-β pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts in vitro

Author(s): Thomas Stahnke, Beata Gajda-Deryło, Anselm G. Jünemann, Oliver Stachs, Katharina A. Sterenczak, Robert Rejdak, Julia Beck, Ekkehard Schütz, Steffen Möller, Israel Barrantes, Gregor Warsow, Stephan Struckmann, Georg Fuellen
Published in: Royal Society Open Science, Issue 7/9, 2020, Page(s) 200441, ISSN 2054-5703
Publisher: Royal Society
DOI: 10.1098/rsos.200441

Ample dietary fat reduced the risk of primary vesical calculi by inducing macrophages to engulf budding crystals in mice

Author(s): Huiling Chen, Kaiqiang Hu, Yaru Liang, Yuqi Gao, Chenye Zeng, Kang Xu, Xiaojin Shi, Liyuan Li, Yuemiao Yin, Yi Qiao, Ying Qiu, Qingfei Liu, Zhao Wang
Published in: Acta Pharmaceutica Sinica B, 2021, ISSN 2211-3835
Publisher: Elsevier B.V.
DOI: 10.1016/j.apsb.2021.08.001

Enhanced Healthspan in Caenorhabditis elegans Treated With Extracts From the Traditional Chinese Medicine Plants Cuscuta chinensis Lam. and Eucommia ulmoides Oliv.

Author(s): Shimaa M. A. Sayed, Karsten Siems, Christian Schmitz-Linneweber, Walter Luyten, Nadine Saul
Published in: Frontiers in Pharmacology, Issue 12, 2021, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.604435

The nutritional requirements of Caenorhabditis elegans

Author(s): Aleksandra Zečić, Ineke Dhondt, Bart P. Braeckman
Published in: Genes & Nutrition, Issue 14/1, 2019, ISSN 1555-8932
Publisher: New Century Health Publishers
DOI: 10.1186/s12263-019-0637-7

FocusHeuristics – expression-data-driven network optimization and disease gene prediction

Author(s): Mathias Ernst, Yang Du, Gregor Warsow, Mohamed Hamed, Nicole Endlich, Karlhans Endlich, Hugo Murua Escobar, Lisa-Madeleine Sklarz, Sina Sender, Christian Junghanß, Steffen Möller, Georg Fuellen, Stephan Struckmann
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep42638

Chronic exposure to rapamycin and episodic serum starvation modulate ageing of human fibroblasts in vitro

Author(s): Lakshman Sodagam, Anna Lewinska, Maciej Wnuk, Suresh I. S. Rattan
Published in: Biogerontology, Issue 18/5, 2017, Page(s) 841-854, ISSN 1389-5729
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10522-017-9730-8

Manhattan Harvester and Cropper: a system for GWAS peak detection

Author(s): Toomas Haller, Tõnis Tasa, Andres Metspalu
Published in: BMC Bioinformatics, Issue 20/1, 2019, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-019-2600-4

Optimized criteria for locomotion-based healthspan evaluation in C. elegans using the WorMotel system

Author(s): Areta Jushaj, Matthew Churgin, Bowen Yao, Miguel De La Torre, Christopher Fang-Yen, Liesbet Temmerman
Published in: PLOS ONE, Issue 15/3, 2020, Page(s) e0229583, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0229583

Healthspan Maintenance and Prevention of Parkinson’s-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans

Author(s): Giovanni Brunetti, Gabriele Di Rosa, Maria Scuto, Manuela Leri, Massimo Stefani, Christian Schmitz-Linneweber, Vittorio Calabrese, Nadine Saul
Published in: International Journal of Molecular Sciences, Issue 21/7, 2020, Page(s) 2588, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072588

Single-cell analyses of aging, inflammation and senescence

Author(s): Bora Uyar, Daniel Palmer, Axel Kowald, Hugo Murua Escobar, Israel Barrantes, Steffen Möller, Altuna Akalin, Georg Fuellen
Published in: Ageing Research Reviews, Issue 64, 2020, Page(s) 101156, ISSN 1568-1637
Publisher: Elsevier BV
DOI: 10.1016/j.arr.2020.101156

Biphasic Dose–Response and Hormetic Effects of Stress Hormone Hydrocortisone on Telomerase-Immortalized Human Bone Marrow Stem Cells In Vitro

Author(s): Indra Kumar Gopi, Suresh I. S. Rattan
Published in: Dose-Response, Issue 17/4, 2019, Page(s) 155932581988981, ISSN 1559-3258
Publisher: International Dose-Response Society
DOI: 10.1177/1559325819889819

Scoring functions for drug-effect similarity

Author(s): Stephan Struckmann, Mathias Ernst, Sarah Fischer, Nancy Mah, Georg Fuellen, Steffen Möller
Published in: Briefings in Bioinformatics, Issue 22/3, 2021, ISSN 1467-5463
Publisher: Oxford University Press
DOI: 10.1093/bib/bbaa072

Genes implicated in Caenorhabditis elegans and human health regulate stress resistance and physical abilities in aged Caenorhabditis elegans

Author(s): Jessica Dysarz, Georg Fuellen, Steffen Möller, Walter Luyten, Christian Schmitz-Linneweber, Nadine Saul
Published in: Biology Letters, Issue 17/6, 2021, Page(s) 20200916, ISSN 1744-957X
Publisher: Royal Society
DOI: 10.1098/rsbl.2020.0916

Prediction of biological age by morphological staging of sarcopenia in Caenorhabditis elegans

Author(s): Ineke Dhondt, Clara Verschuuren, Aleksandra Zečić , Tim Loier, Bart P. Braeckman, Winnok H. De Vos
Published in: Disease Models & Mechanisms, 2021, ISSN 1754-8411
Publisher: The Company of Biologists Ltd
DOI: 10.1242/dmm.049169

Administration of the Antioxidant N-Acetyl-Cysteine in Pregnant Mice Has Long-Term Positive Effects on Metabolic and Behavioral Endpoints of Male and Female Offspring Prenatally Exposed to a High-Fat Diet

Author(s): Alessandra Berry, Veronica Bellisario, Pamela Panetta, Carla Raggi, Maria C. Magnifico, Marzia Arese, Francesca Cirulli
Published in: Frontiers in Behavioral Neuroscience, Issue 12, 2018, ISSN 1662-5153
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2018.00048

The genetic predisposition to longevity acts through behavioral phenotypes in females

Author(s): Sandra Van der Auwera, Linda Garvert, Georg Fuellen, Matthias Nauck, Henry Völzke, Uwe Völker, Hans J. Grabe
Published in: European Neuropsychopharmacology, Issue 45, 2021, Page(s) 1-14, ISSN 0924-977X
Publisher: Elsevier BV
DOI: 10.1016/j.euroneuro.2021.02.014

Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India

Author(s): Sujogya Kumar Panda, Walter Luyten
Published in: Parasite, Issue 25, 2018, Page(s) 10, ISSN 1776-1042
Publisher: EDP Sciences
DOI: 10.1051/parasite/2018008

The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice

Author(s): Huiling Chen, Qing Huang, Shunjia Zhang, Kaiqiang Hu, Wenxiang Xiong, Lingyun Xiao, Renhuai Cong, Qingfei Liu, Zhao Wang
Published in: Nutrients, Issue 11/4, 2019, Page(s) 859, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu11040859

In vitro aggregating β-lactamase-polyQ chimeras do not induce toxic effects in an in vivo Caenorhabditis elegans model

Author(s): Roel Van Assche; Charline Borghgraef; Jonathan Vaneyck; Mireille Dumoulin; Liliane Schoofs; Liesbet Temmerman
Published in: Journal of Negative Results in Biomedicine, Issue 6, 2017, Page(s) 1-14, ISSN 1477-5751
Publisher: BioMed Central
DOI: 10.1186/s12952-017-0080-5

Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson’s Models

Author(s): Gabriele Di Rosa, Giovanni Brunetti, Maria Scuto, Angela Trovato Salinaro, Edward J. Calabrese, Roberto Crea, Christian Schmitz-Linneweber, Vittorio Calabrese, Nadine Saul
Published in: International Journal of Molecular Sciences, Issue 21/11, 2020, Page(s) 3893, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21113893

Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing

Author(s): Georg Fuellen, Paul Schofield, Thomas Flatt, Ralf-Joachim Schulz, Fritz Boege, Karin Kraft, Gerald Rimbach, Saleh Ibrahim, Alexander Tietz, Christian Schmidt, Rüdiger Köhling, Andreas Simm
Published in: Gerontology, Issue 62/4, 2016, Page(s) 409-416, ISSN 0304-324X
Publisher: S. Karger AG
DOI: 10.1159/000442746

Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone

Author(s): Daniela Ohde, Mark Moeller, Julia Brenmoehl, Christina Walz, Siriluck Ponsuksili, Manfred Schwerin, Georg Fuellen, Andreas Hoeflich
Published in: PLOS ONE, Issue 11/1, 2016, Page(s) e0146748, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0146748

Ageing with elegans: a research proposal to map healthspan pathways

Author(s): Walter Luyten, Peter Antal, Bart P. Braeckman, Jake Bundy, Francesca Cirulli, Christopher Fang-Yen, Georg Fuellen, Armand Leroi, Qingfei Liu, Patricia Martorell, Andres Metspalu, Markus Perola, Michael Ristow, Nadine Saul, Liliane Schoofs, Karsten Siems, Liesbet Temmerman, Tina Smets, Alicja Wolk, Suresh I. S. Rattan
Published in: Biogerontology, Issue 17/4, 2016, Page(s) 771-782, ISSN 1389-5729
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10522-016-9644-x

ClonoCalc and ClonoPlot: immune repertoire analysis from raw files to publication figures with graphical user interface

Author(s): Anke Fähnrich; Moritz Krebbel; Normann Decker; Martin Leucker; Felix D. Lange; Kathrin Kalies; Steffen Möller
Published in: BMC Bioinformatics, Issue 3, 2017, Page(s) 1-6, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-017-1575-2

Maternal Obesity as a Risk Factor for Brain Development and Mental Health in the Offspring

Author(s): Francesca Cirulli, Chiara Musillo, Alessandra Berry
Published in: Neuroscience, Issue 447, 2020, Page(s) 122-135, ISSN 0306-4522
Publisher: Elsevier BV
DOI: 10.1016/j.neuroscience.2020.01.023

Curcuma Longa, the “Golden Spice” to Counteract Neuroinflammaging and Cognitive Decline—What Have We Learned and What Needs to Be Done

Author(s): Alessandra Berry, Barbara Collacchi, Roberta Masella, Rosaria Varì, Francesca Cirulli
Published in: Nutrients, Issue 13/5, 2021, Page(s) 1519, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13051519

Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies

Author(s): Nadine Saul, Steffen Möller, Francesca Cirulli, Alessandra Berry, Walter Luyten, Georg Fuellen
Published in: Biogerontology, Issue 22/2, 2021, Page(s) 215-236, ISSN 1389-5729
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10522-021-09913-2

Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss

Author(s): Heikki V. Sarin, Ivan Gudelj, Jarno Honkanen, Johanna K. Ihalainen, Arja Vuorela, Joseph H. Lee, Zhenzhen Jin, Joseph D. Terwilliger, Ville Isola, Juha P. Ahtiainen, Keijo Häkkinen, Julija Jurić, Gordan Lauc, Kati Kristiansson, Juha J. Hulmi, Markus Perola
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2019.00907

Comparison of cytokine/chemokine levels in aqueous humor of primary open-angle glaucoma patients with positive or negative outcome following trabeculectomy

Author(s): Beata Gajda-Deryło; Thomas Stahnke; Stephan Struckmann; Gregor Warsow; Kerstin Birke; Marco T. Birke; Bettina Hohberger; Robert Rejdak; Georg Fuellen; Anselm G. Jünemann
Published in: Bioscience reports, Issue 4, 2019, Page(s) 1-11, ISSN 1573-4935
Publisher: Portland PRess
DOI: 10.1042/bsr20181894

Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves

Author(s): Yaru Liang, Chang Liu, Maoyang Lu, Qiongye Dong, Zimu Wang, Zhuoran Wang, Wenxiang Xiong, Nannan Zhang, Jiawei Zhou, Qingfei Liu, Xiaowo Wang, Zhao Wang
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-24146-z

Exploring neuropeptide signalling through proteomics and peptidomics

Author(s): Samantha Louise Edwards, Lucas Mergan, Bhavesh Parmar, Bram Cockx, Wouter De Haes, Liesbet Temmerman, Liliane Schoofs
Published in: Expert Review of Proteomics, Issue 16/2, 2019, Page(s) 131-137, ISSN 1478-9450
Publisher: Future Drugs Ltd.
DOI: 10.1080/14789450.2019.1559733

Robust Cross-Platform Workflows: How Technical and Scientific Communities Collaborate to Develop, Test and Share Best Practices for Data Analysis

Author(s): Steffen Möller, Stuart W. Prescott, Lars Wirzenius, Petter Reinholdtsen, Brad Chapman, Pjotr Prins, Stian Soiland-Reyes, Fabian Klötzl, Andrea Bagnacani, Matúš Kalaš, Andreas Tille, Michael R. Crusoe
Published in: Data Science and Engineering, Issue 2/3, 2017, Page(s) 232-244, ISSN 2364-1185
Publisher: Springer Verlag
DOI: 10.1007/s41019-017-0050-4

Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder

Author(s): Zhuoran Wang, Yaru Liang, Lu Zhang, Nannan Zhang, Qingfei Liu, Zhao Wang
Published in: Aging, Issue 10/9, 2018, Page(s) 2394-2406, ISSN 1945-4589
Publisher: Impact Journals, LLC
DOI: 10.18632/aging.101559

The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging)

Author(s): Georg Fuellen, Oliver Liesenfeld, Axel Kowald, Israel Barrantes, Manuela Bastian, Andreas Simm, Ludger Jansen, Alexander Tietz-Latza, Dagmar Quandt, Claudio Franceschi, Michael Walter
Published in: Ageing Research Reviews, Issue 62, 2020, Page(s) 101091, ISSN 1568-1637
Publisher: Elsevier BV
DOI: 10.1016/j.arr.2020.101091

Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging

Author(s): Matthew A Churgin, Sang-Kyu Jung, Chih-Chieh Yu, Xiangmei Chen, David M Raizen, Christopher Fang-Yen
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.26652

Long-Term Sex-Dependent Vulnerability to Metabolic challenges in Prenatally Stressed Rats

Author(s): Pamela Panetta, Alessandra Berry, Veronica Bellisario, Sara Capoccia, Carla Raggi, Alessia Luoni, Linda Longo, Marco A. Riva, Francesca Cirulli
Published in: Frontiers in Behavioral Neuroscience, Issue 11, 2017, ISSN 1662-5153
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2017.00113

Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis

Author(s): Chiara Musillo, Marta Borgi, Nadine Saul, Steffen Möller, Walter Luyten, Alessandra Berry, Francesca Cirulli
Published in: Neuroscience & Biobehavioral Reviews, Issue 121, 2021, Page(s) 89-105, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.12.001

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation

Author(s): Nath Artika P; Ritchie Scott C; Byars Sean G; Fearnley Liam G; Havulinna Aki S; Joensuu Anni; Kangas Antti J; Soininen Pasi; Wennerström Annika; Milani Lili; Metspalu Andres; Männistö Satu; Würtz Peter; Kettunen Johannes; Raitoharju Emma; Kähönen Mika; Juonala Markus; Palotie Aarno; Ala-Korpela Mika; Ripatti Samuli et al.
Published in: Genome Biology, Issue 3, 2017, ISSN 1474-760X
Publisher: Springer Verlag
DOI: 10.1186/s13059-017-1279-y

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Author(s): Misa Hirose, Paul Schilf, Yask Gupta, Kim Zarse, Axel Künstner, Anke Fähnrich, Hauke Busch, Junping Yin, Marvin N. Wright, Andreas Ziegler, Marie Vallier, Meriem Belheouane, John F Baines, Diethard Tautz, Kornelia Johann, Rebecca Oelkrug, Jens Mittag, Hendrik Lehnert, Alaa Othman, Olaf Jöhren, Markus Schwaninger, Cornelia Prehn, Jerzy Adamski, Kensuke Shima, Jan Rupp, Robert Häsler, Georg Fuel
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-24290-6

Plant-Derived Molecules α-Boswellic Acid Acetate, Praeruptorin-A, and Salvianolic Acid-B Have Age-Related Differential Effects in Young and Senescent Human Fibroblasts In Vitro

Author(s): Anna Lewinska, Lakshman Sodagam, Dominika Bloniarz, Karsten Siems, Maciej Wnuk, Suresh I. S. Rattan
Published in: Molecules, Issue 25/1, 2020, Page(s) 141, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25010141

Combination of mitochondrial tRNA and OXPHOS mutation reduces lifespan and physical condition in aged mice

Author(s): Gesine Reichart; Johannes Mayer; Tursonjan Tokay; Falko Lange; C Johne; Simone Baltrusch; Markus Tiedge; Georg Fuellen; Saleh M. Ibrahim; Rüdiger Köhling
Published in: Issue 1, 2017
Publisher: bioRxiv
DOI: 10.1101/233593

Royalactin induces copious longevity via increased translation and proteasome activity in C. elegans

Author(s): Detienne, Giel; Van de Walle, Pieter; De Haes, Wouter; Cockx, Bram; Braeckman, Bart P.; Schoofs, Liliane; Temmerman, Liesbet
Published in: Issue 2, 2018
Publisher: BioRxiv

Gene co-expression analyses of health(span) across multiple species

Author(s): Steffen Möller, Nadine Saul, Israel Barrantes, András Gézsi, Michael Walter, Péter Antal, Georg Fuellen
Published in: bioRxiv, 2021
Publisher: Cold Spring Harbot Laboratory
DOI: 10.1101/2021.04.08.439030

Pathway maps enable straightforward yet customized and semi-automated yet insightful analyses of omics data

Author(s): Steffen Möller; Israel Barrantes; Robert Jaster; Larissa Henze; Hugo Murua Escobar; Christian Junghanß; Oliver W. Hakenberg; Marc-André Weber; Bernd J. Krause; Olaf Wolkenhauer; Saleh M. Ibrahim; Rüdiger Köhling; Falko Lange; Uwe Walter; Mohamed Hamed; Axel Kowald; Georg Fuellen
Published in: 2018
Publisher: BopRxiv
DOI: 10.1101/404525

Western diet combined with rosmarinic acid in old mice exerts negative effects on metabolism but improves cognitive and emotional behaviour in a sex-dependent fashion

Author(s): MUSILLO, CHIARA; POGGINI, SILVIA; Gaia De Cristofaro,; Kim, Zarse; Michael, Ristow; Bundy, Jacob G.; Virag, Sagi-Kiss; Karsten, Siems; Walter, Luyten; Alessandra, Berry; Francesca, Cirulli
Published in: Issue 1, 2019
Publisher: ISSS

Antioxidant N-acetyl-cysteine administration in pregnant mice has long-term positive effects on metabolic and behavioural endpoints of male and female offspring prenatally exposed to a high-fat-diet

Author(s): Alessandra, Berry; Pamela, Panetta; Carla, Raggi; MUSILLO, CHIARA; Gaia De Cristofaro,; MAGNIFICO, MARIA CHIARA; ARESE, Marzia; Francesca, Cirulli
Published in: Issue 1, 2018
Publisher: 11th FENS Forum

Healthspan pathway maps in model organisms and human

Author(s): Fuellen, Georg; Möller, Steffen; Saul, Nadine; Cirulli, Francesca; Jansen, Ludger; Antal, Peter; Luyten, Walter
Published in: 63. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); 20180902-20180906; Osnabrück; DOCAbstr. 153 /20180827/, Issue 1, 2018
Publisher: Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS)
DOI: 10.3205/18gmds162

Improving our understanding of sex-dependent mechanisms regulating healthspan through novel methodological approaches

Author(s): Alessandra, Berry; Carla, Raggi; MUSILLO, CHIARA; Gaia De Cristofaro,; BRANCHI, Igor; POGGINI, SILVIA; Aurelia, Viglione; Francesca, Cirulli
Published in: 2018
Publisher: 11th FENS Forum

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