Validating C. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Project website

Project website with public and (secure) consortium partition

Two compound patents filed

Two patents filed on plant extracts or compounds prolonging healthspan

Press release

D8.1: Press releases (M1 at occasion of kick-off, and upon major discoveries)

C. elegans reporter strains

Report and publication(s) on validated set of C. elegans reporter strains with reporters for all known healthspan pathways to permit quick assessment of candidate treatments

Compounds affecting healthspan in mice

Reports and publications on compounds affecting healthspan in mice

Book published

Book published in Springer series Health Ageing and Longevity M60

Mechanism of action

Reports and publications on compounds with molecular mechanism demonstrated to be similar in C. elegans and human cells

Validated healthspan polymorphisms

Report of validated polymorphisms predictive of better (or worse) health in the aged, stratified by sex and gender, and mapped onto pathways

Sex and gender dependency

Reports and publications on dependency on sex and gender of healthspan effects

Healthspan compounds

Reports and publications on compounds that prolong healthspan in C. elegans, and their mechanism of action

Non-pharmacological C. elegans models

Report and publication(s) on models for non-pharmacological treatments in C. elegans

Preparations with activity in mammalian cells

Report and submitted publication on individual compounds and complex extracts with health-promoting activity in relevant mammalian cellular assay.

Publications

Trehalose administration in C57BL/6N old mice affects healthspan improving motor learning and brain anti-oxidant defences in a sex-dependent fashion: a pilot study

Auteurs: Alessandra Berry, Matteo Marconi, Chiara Musillo, Flavia Chiarotti, Veronica Bellisario, Paola Matarrese, Lucrezia Gambardella, Rosa Vona, Maria Lombardi, Chiara Foglieni, Francesca Cirulli
Publié dans: Experimental Gerontology, Numéro 129, 2020, Page(s) 110755, ISSN 0531-5565
Éditeur: Elsevier BV
DOI: 10.1016/j.exger.2019.110755

Search for Early Pancreatic Cancer Blood Biomarkers in Five European Prospective Population Biobanks Using Metabolomics

Auteurs: Jesse Fest, Lisanne S Vijfhuizen, Jelle J Goeman, Olga Veth, Anni Joensuu, Markus Perola, Satu Männistö, Eivind Ness-Jensen, Kristian Hveem, Toomas Haller, Neeme Tonisson, Kairit Mikkel, Andres Metspalu, Cornelia M van Duijn, Arfan Ikram, Bruno H Stricker, Rikje Ruiter, Casper H J van Eijck, Gert-Jan B van Ommen, Peter A C ʼt Hoen
Publié dans: Endocrinology, Numéro 160/7, 2019, Page(s) 1731-1742, ISSN 1945-7170
Éditeur: Oxford University Press
DOI: 10.1210/en.2019-00165

Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids

Auteurs: Steffen Möller, Nadine Saul, Alan A. Cohen, Rüdiger Köhling, Sina Sender, Hugo Murua Escobar, Christian Junghanss, Francesca Cirulli, Alessandra Berry, Peter Antal, Priit Adler, Jaak Vilo, Michele Boiani, Ludger Jansen, Dirk Repsilber, Hans Jörgen Grabe, Stephan Struckmann, Israel Barrantes, Mohamed Hamed, Brecht Wouters, Liliane Schoofs, Walter Luyten, Georg Fuellen
Publié dans: Aging, Numéro 12/13, 2020, Page(s) 12534-12581, ISSN 1945-4589
Éditeur: Impact Journals, LLC
DOI: 10.18632/aging.103514

Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation

Auteurs: Fei Yan, Qi Zhao, Huanpeng Gao, Xiaomei Wang, Ke Xu, Yishu Wang, Fuguo Han, Qingfei Liu, Yun Shi
Publié dans: Bioscience Reports, Numéro 41/2, 2021, ISSN 0144-8463
Éditeur: Kluwer Academic Publishers
DOI: 10.1042/bsr20203955

Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A.

Auteurs: Leonid Rozanov; Meenakshi Ravichandran; Giovanna Grigolon; Maria Clara Zanellati; Johannes Mansfeld; Kim Zarse; Nir Barzilai; Gil Atzmon; Gil Atzmon; Fabian Fischer; Michael Ristow
Publié dans: Redox Biology, Numéro 3, 2020, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.3929/ethz-b-000406666

Dynamic changes in p66Shc mRNA expression in peripheral blood mononuclear cells following resistance training intervention in old frail women born to obese mothers: a pilot study

Auteurs: Alessandra Berry, Marco Bucci, Carla Raggi, Johan G. Eriksson, Maria Angela Guzzardi, Pirjo Nuutila, Ville Huovinen, Patricia Iozzo, Francesca Cirulli
Publié dans: Aging Clinical and Experimental Research, Numéro 30/7, 2018, Page(s) 871-876, ISSN 1720-8319
Éditeur: Springer Verlag
DOI: 10.1007/s40520-017-0834-4

Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice

Auteurs: Gesine Reichart, Johannes Mayer, Cindy Zehm, Timo Kirschstein, Tursonjan Tokay, Falko Lange, Simone Baltrusch, Markus Tiedge, Georg Fuellen, Saleh Ibrahim, Rüdiger Köhling
Publié dans: Acta Physiologica, Numéro 225/4, 2018, Page(s) e13214, ISSN 1748-1708
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/apha.13214

Phytochemicals Rosmarinic Acid, Ampelopsin, and Amorfrutin-A Can Modulate Age-Related Phenotype of Serially Passaged Human Skin Fibroblasts in vitro

Auteurs: Lakshman Sodagam, Anna Lewinska, Ewa Kwasniewicz, Sofiya Kokhanovska, Maciej Wnuk, Karsten Siems, Suresh I. S. Rattan
Publié dans: Frontiers in Genetics, Numéro 10, 2019, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2019.00081

Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways

Auteurs: Georg Fuellen, Ludger Jansen, Alan A Cohen, Walter Luyten, Manfred Gogol, Andreas Simm, Nadine Saul, Francesca Cirulli, Alessandra Berry, Peter Antal, Rüdiger Köhling, Brecht Wouters, Steffen Möller
Publié dans: Aging and disease, Numéro 10/4, 2019, Page(s) 883, ISSN 2152-5250
Éditeur: International Society on Aging and Disease
DOI: 10.14336/ad.2018.1030

Suppression of the TGF-β pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts in vitro

Auteurs: Thomas Stahnke, Beata Gajda-Deryło, Anselm G. Jünemann, Oliver Stachs, Katharina A. Sterenczak, Robert Rejdak, Julia Beck, Ekkehard Schütz, Steffen Möller, Israel Barrantes, Gregor Warsow, Stephan Struckmann, Georg Fuellen
Publié dans: Royal Society Open Science, Numéro 7/9, 2020, Page(s) 200441, ISSN 2054-5703
Éditeur: Royal Society
DOI: 10.1098/rsos.200441

Ample dietary fat reduced the risk of primary vesical calculi by inducing macrophages to engulf budding crystals in mice

Auteurs: Huiling Chen, Kaiqiang Hu, Yaru Liang, Yuqi Gao, Chenye Zeng, Kang Xu, Xiaojin Shi, Liyuan Li, Yuemiao Yin, Yi Qiao, Ying Qiu, Qingfei Liu, Zhao Wang
Publié dans: Acta Pharmaceutica Sinica B, 2021, ISSN 2211-3835
Éditeur: Elsevier B.V.
DOI: 10.1016/j.apsb.2021.08.001

Enhanced Healthspan in Caenorhabditis elegans Treated With Extracts From the Traditional Chinese Medicine Plants Cuscuta chinensis Lam. and Eucommia ulmoides Oliv.

Auteurs: Shimaa M. A. Sayed, Karsten Siems, Christian Schmitz-Linneweber, Walter Luyten, Nadine Saul
Publié dans: Frontiers in Pharmacology, Numéro 12, 2021, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.604435

The nutritional requirements of Caenorhabditis elegans

Auteurs: Aleksandra Zečić, Ineke Dhondt, Bart P. Braeckman
Publié dans: Genes & Nutrition, Numéro 14/1, 2019, ISSN 1555-8932
Éditeur: New Century Health Publishers
DOI: 10.1186/s12263-019-0637-7

FocusHeuristics – expression-data-driven network optimization and disease gene prediction

Auteurs: Mathias Ernst, Yang Du, Gregor Warsow, Mohamed Hamed, Nicole Endlich, Karlhans Endlich, Hugo Murua Escobar, Lisa-Madeleine Sklarz, Sina Sender, Christian Junghanß, Steffen Möller, Georg Fuellen, Stephan Struckmann
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep42638

Chronic exposure to rapamycin and episodic serum starvation modulate ageing of human fibroblasts in vitro

Auteurs: Lakshman Sodagam, Anna Lewinska, Maciej Wnuk, Suresh I. S. Rattan
Publié dans: Biogerontology, Numéro 18/5, 2017, Page(s) 841-854, ISSN 1389-5729
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10522-017-9730-8

Manhattan Harvester and Cropper: a system for GWAS peak detection

Auteurs: Toomas Haller, Tõnis Tasa, Andres Metspalu
Publié dans: BMC Bioinformatics, Numéro 20/1, 2019, ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.1186/s12859-019-2600-4

Optimized criteria for locomotion-based healthspan evaluation in C. elegans using the WorMotel system

Auteurs: Areta Jushaj, Matthew Churgin, Bowen Yao, Miguel De La Torre, Christopher Fang-Yen, Liesbet Temmerman
Publié dans: PLOS ONE, Numéro 15/3, 2020, Page(s) e0229583, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0229583

Healthspan Maintenance and Prevention of Parkinson’s-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans

Auteurs: Giovanni Brunetti, Gabriele Di Rosa, Maria Scuto, Manuela Leri, Massimo Stefani, Christian Schmitz-Linneweber, Vittorio Calabrese, Nadine Saul
Publié dans: International Journal of Molecular Sciences, Numéro 21/7, 2020, Page(s) 2588, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072588

Single-cell analyses of aging, inflammation and senescence

Auteurs: Bora Uyar, Daniel Palmer, Axel Kowald, Hugo Murua Escobar, Israel Barrantes, Steffen Möller, Altuna Akalin, Georg Fuellen
Publié dans: Ageing Research Reviews, Numéro 64, 2020, Page(s) 101156, ISSN 1568-1637
Éditeur: Elsevier BV
DOI: 10.1016/j.arr.2020.101156

Biphasic Dose–Response and Hormetic Effects of Stress Hormone Hydrocortisone on Telomerase-Immortalized Human Bone Marrow Stem Cells In Vitro

Auteurs: Indra Kumar Gopi, Suresh I. S. Rattan
Publié dans: Dose-Response, Numéro 17/4, 2019, Page(s) 155932581988981, ISSN 1559-3258
Éditeur: International Dose-Response Society
DOI: 10.1177/1559325819889819

Scoring functions for drug-effect similarity

Auteurs: Stephan Struckmann, Mathias Ernst, Sarah Fischer, Nancy Mah, Georg Fuellen, Steffen Möller
Publié dans: Briefings in Bioinformatics, Numéro 22/3, 2021, ISSN 1467-5463
Éditeur: Oxford University Press
DOI: 10.1093/bib/bbaa072

Genes implicated in Caenorhabditis elegans and human health regulate stress resistance and physical abilities in aged Caenorhabditis elegans

Auteurs: Jessica Dysarz, Georg Fuellen, Steffen Möller, Walter Luyten, Christian Schmitz-Linneweber, Nadine Saul
Publié dans: Biology Letters, Numéro 17/6, 2021, Page(s) 20200916, ISSN 1744-957X
Éditeur: Royal Society
DOI: 10.1098/rsbl.2020.0916

Prediction of biological age by morphological staging of sarcopenia in Caenorhabditis elegans

Auteurs: Ineke Dhondt, Clara Verschuuren, Aleksandra Zečić , Tim Loier, Bart P. Braeckman, Winnok H. De Vos
Publié dans: Disease Models & Mechanisms, 2021, ISSN 1754-8411
Éditeur: The Company of Biologists Ltd
DOI: 10.1242/dmm.049169

Administration of the Antioxidant N-Acetyl-Cysteine in Pregnant Mice Has Long-Term Positive Effects on Metabolic and Behavioral Endpoints of Male and Female Offspring Prenatally Exposed to a High-Fat Diet

Auteurs: Alessandra Berry, Veronica Bellisario, Pamela Panetta, Carla Raggi, Maria C. Magnifico, Marzia Arese, Francesca Cirulli
Publié dans: Frontiers in Behavioral Neuroscience, Numéro 12, 2018, ISSN 1662-5153
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2018.00048

The genetic predisposition to longevity acts through behavioral phenotypes in females

Auteurs: Sandra Van der Auwera, Linda Garvert, Georg Fuellen, Matthias Nauck, Henry Völzke, Uwe Völker, Hans J. Grabe
Publié dans: European Neuropsychopharmacology, Numéro 45, 2021, Page(s) 1-14, ISSN 0924-977X
Éditeur: Elsevier BV
DOI: 10.1016/j.euroneuro.2021.02.014

Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India

Auteurs: Sujogya Kumar Panda, Walter Luyten
Publié dans: Parasite, Numéro 25, 2018, Page(s) 10, ISSN 1776-1042
Éditeur: EDP Sciences
DOI: 10.1051/parasite/2018008

The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice

Auteurs: Huiling Chen, Qing Huang, Shunjia Zhang, Kaiqiang Hu, Wenxiang Xiong, Lingyun Xiao, Renhuai Cong, Qingfei Liu, Zhao Wang
Publié dans: Nutrients, Numéro 11/4, 2019, Page(s) 859, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu11040859

In vitro aggregating β-lactamase-polyQ chimeras do not induce toxic effects in an in vivo Caenorhabditis elegans model

Auteurs: Roel Van Assche; Charline Borghgraef; Jonathan Vaneyck; Mireille Dumoulin; Liliane Schoofs; Liesbet Temmerman
Publié dans: Journal of Negative Results in Biomedicine, Numéro 6, 2017, Page(s) 1-14, ISSN 1477-5751
Éditeur: BioMed Central
DOI: 10.1186/s12952-017-0080-5

Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson’s Models

Auteurs: Gabriele Di Rosa, Giovanni Brunetti, Maria Scuto, Angela Trovato Salinaro, Edward J. Calabrese, Roberto Crea, Christian Schmitz-Linneweber, Vittorio Calabrese, Nadine Saul
Publié dans: International Journal of Molecular Sciences, Numéro 21/11, 2020, Page(s) 3893, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21113893

Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing

Auteurs: Georg Fuellen, Paul Schofield, Thomas Flatt, Ralf-Joachim Schulz, Fritz Boege, Karin Kraft, Gerald Rimbach, Saleh Ibrahim, Alexander Tietz, Christian Schmidt, Rüdiger Köhling, Andreas Simm
Publié dans: Gerontology, Numéro 62/4, 2016, Page(s) 409-416, ISSN 0304-324X
Éditeur: S. Karger AG
DOI: 10.1159/000442746

Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone

Auteurs: Daniela Ohde, Mark Moeller, Julia Brenmoehl, Christina Walz, Siriluck Ponsuksili, Manfred Schwerin, Georg Fuellen, Andreas Hoeflich
Publié dans: PLOS ONE, Numéro 11/1, 2016, Page(s) e0146748, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0146748

Ageing with elegans: a research proposal to map healthspan pathways

Auteurs: Walter Luyten, Peter Antal, Bart P. Braeckman, Jake Bundy, Francesca Cirulli, Christopher Fang-Yen, Georg Fuellen, Armand Leroi, Qingfei Liu, Patricia Martorell, Andres Metspalu, Markus Perola, Michael Ristow, Nadine Saul, Liliane Schoofs, Karsten Siems, Liesbet Temmerman, Tina Smets, Alicja Wolk, Suresh I. S. Rattan
Publié dans: Biogerontology, Numéro 17/4, 2016, Page(s) 771-782, ISSN 1389-5729
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10522-016-9644-x

ClonoCalc and ClonoPlot: immune repertoire analysis from raw files to publication figures with graphical user interface

Auteurs: Anke Fähnrich; Moritz Krebbel; Normann Decker; Martin Leucker; Felix D. Lange; Kathrin Kalies; Steffen Möller
Publié dans: BMC Bioinformatics, Numéro 3, 2017, Page(s) 1-6, ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.1186/s12859-017-1575-2

Maternal Obesity as a Risk Factor for Brain Development and Mental Health in the Offspring

Auteurs: Francesca Cirulli, Chiara Musillo, Alessandra Berry
Publié dans: Neuroscience, Numéro 447, 2020, Page(s) 122-135, ISSN 0306-4522
Éditeur: Elsevier BV
DOI: 10.1016/j.neuroscience.2020.01.023

Curcuma Longa, the “Golden Spice” to Counteract Neuroinflammaging and Cognitive Decline—What Have We Learned and What Needs to Be Done

Auteurs: Alessandra Berry, Barbara Collacchi, Roberta Masella, Rosaria Varì, Francesca Cirulli
Publié dans: Nutrients, Numéro 13/5, 2021, Page(s) 1519, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13051519

Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies

Auteurs: Nadine Saul, Steffen Möller, Francesca Cirulli, Alessandra Berry, Walter Luyten, Georg Fuellen
Publié dans: Biogerontology, Numéro 22/2, 2021, Page(s) 215-236, ISSN 1389-5729
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10522-021-09913-2

Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss

Auteurs: Heikki V. Sarin, Ivan Gudelj, Jarno Honkanen, Johanna K. Ihalainen, Arja Vuorela, Joseph H. Lee, Zhenzhen Jin, Joseph D. Terwilliger, Ville Isola, Juha P. Ahtiainen, Keijo Häkkinen, Julija Jurić, Gordan Lauc, Kati Kristiansson, Juha J. Hulmi, Markus Perola
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2019.00907

Comparison of cytokine/chemokine levels in aqueous humor of primary open-angle glaucoma patients with positive or negative outcome following trabeculectomy

Auteurs: Beata Gajda-Deryło; Thomas Stahnke; Stephan Struckmann; Gregor Warsow; Kerstin Birke; Marco T. Birke; Bettina Hohberger; Robert Rejdak; Georg Fuellen; Anselm G. Jünemann
Publié dans: Bioscience reports, Numéro 4, 2019, Page(s) 1-11, ISSN 1573-4935
Éditeur: Portland PRess
DOI: 10.1042/bsr20181894

Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves

Auteurs: Yaru Liang, Chang Liu, Maoyang Lu, Qiongye Dong, Zimu Wang, Zhuoran Wang, Wenxiang Xiong, Nannan Zhang, Jiawei Zhou, Qingfei Liu, Xiaowo Wang, Zhao Wang
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-24146-z

Exploring neuropeptide signalling through proteomics and peptidomics

Auteurs: Samantha Louise Edwards, Lucas Mergan, Bhavesh Parmar, Bram Cockx, Wouter De Haes, Liesbet Temmerman, Liliane Schoofs
Publié dans: Expert Review of Proteomics, Numéro 16/2, 2019, Page(s) 131-137, ISSN 1478-9450
Éditeur: Future Drugs Ltd.
DOI: 10.1080/14789450.2019.1559733

Robust Cross-Platform Workflows: How Technical and Scientific Communities Collaborate to Develop, Test and Share Best Practices for Data Analysis

Auteurs: Steffen Möller, Stuart W. Prescott, Lars Wirzenius, Petter Reinholdtsen, Brad Chapman, Pjotr Prins, Stian Soiland-Reyes, Fabian Klötzl, Andrea Bagnacani, Matúš Kalaš, Andreas Tille, Michael R. Crusoe
Publié dans: Data Science and Engineering, Numéro 2/3, 2017, Page(s) 232-244, ISSN 2364-1185
Éditeur: Springer Verlag
DOI: 10.1007/s41019-017-0050-4

Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder

Auteurs: Zhuoran Wang, Yaru Liang, Lu Zhang, Nannan Zhang, Qingfei Liu, Zhao Wang
Publié dans: Aging, Numéro 10/9, 2018, Page(s) 2394-2406, ISSN 1945-4589
Éditeur: Impact Journals, LLC
DOI: 10.18632/aging.101559

The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging)

Auteurs: Georg Fuellen, Oliver Liesenfeld, Axel Kowald, Israel Barrantes, Manuela Bastian, Andreas Simm, Ludger Jansen, Alexander Tietz-Latza, Dagmar Quandt, Claudio Franceschi, Michael Walter
Publié dans: Ageing Research Reviews, Numéro 62, 2020, Page(s) 101091, ISSN 1568-1637
Éditeur: Elsevier BV
DOI: 10.1016/j.arr.2020.101091

Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging

Auteurs: Matthew A Churgin, Sang-Kyu Jung, Chih-Chieh Yu, Xiangmei Chen, David M Raizen, Christopher Fang-Yen
Publié dans: eLife, Numéro 6, 2017, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.26652

Long-Term Sex-Dependent Vulnerability to Metabolic challenges in Prenatally Stressed Rats

Auteurs: Pamela Panetta, Alessandra Berry, Veronica Bellisario, Sara Capoccia, Carla Raggi, Alessia Luoni, Linda Longo, Marco A. Riva, Francesca Cirulli
Publié dans: Frontiers in Behavioral Neuroscience, Numéro 11, 2017, ISSN 1662-5153
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2017.00113

Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis

Auteurs: Chiara Musillo, Marta Borgi, Nadine Saul, Steffen Möller, Walter Luyten, Alessandra Berry, Francesca Cirulli
Publié dans: Neuroscience & Biobehavioral Reviews, Numéro 121, 2021, Page(s) 89-105, ISSN 0149-7634
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.12.001

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation

Auteurs: Nath Artika P; Ritchie Scott C; Byars Sean G; Fearnley Liam G; Havulinna Aki S; Joensuu Anni; Kangas Antti J; Soininen Pasi; Wennerström Annika; Milani Lili; Metspalu Andres; Männistö Satu; Würtz Peter; Kettunen Johannes; Raitoharju Emma; Kähönen Mika; Juonala Markus; Palotie Aarno; Ala-Korpela Mika; Ripatti Samuli et al.
Publié dans: Genome Biology, Numéro 3, 2017, ISSN 1474-760X
Éditeur: Springer Verlag
DOI: 10.1186/s13059-017-1279-y

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Auteurs: Misa Hirose, Paul Schilf, Yask Gupta, Kim Zarse, Axel Künstner, Anke Fähnrich, Hauke Busch, Junping Yin, Marvin N. Wright, Andreas Ziegler, Marie Vallier, Meriem Belheouane, John F Baines, Diethard Tautz, Kornelia Johann, Rebecca Oelkrug, Jens Mittag, Hendrik Lehnert, Alaa Othman, Olaf Jöhren, Markus Schwaninger, Cornelia Prehn, Jerzy Adamski, Kensuke Shima, Jan Rupp, Robert Häsler, Georg Fuel
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-24290-6

Plant-Derived Molecules α-Boswellic Acid Acetate, Praeruptorin-A, and Salvianolic Acid-B Have Age-Related Differential Effects in Young and Senescent Human Fibroblasts In Vitro

Auteurs: Anna Lewinska, Lakshman Sodagam, Dominika Bloniarz, Karsten Siems, Maciej Wnuk, Suresh I. S. Rattan
Publié dans: Molecules, Numéro 25/1, 2020, Page(s) 141, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25010141

Combination of mitochondrial tRNA and OXPHOS mutation reduces lifespan and physical condition in aged mice

Auteurs: Gesine Reichart; Johannes Mayer; Tursonjan Tokay; Falko Lange; C Johne; Simone Baltrusch; Markus Tiedge; Georg Fuellen; Saleh M. Ibrahim; Rüdiger Köhling
Publié dans: Numéro 1, 2017
Éditeur: bioRxiv
DOI: 10.1101/233593

Royalactin induces copious longevity via increased translation and proteasome activity in C. elegans

Auteurs: Detienne, Giel; Van de Walle, Pieter; De Haes, Wouter; Cockx, Bram; Braeckman, Bart P.; Schoofs, Liliane; Temmerman, Liesbet
Publié dans: Numéro 2, 2018
Éditeur: BioRxiv

Gene co-expression analyses of health(span) across multiple species

Auteurs: Steffen Möller, Nadine Saul, Israel Barrantes, András Gézsi, Michael Walter, Péter Antal, Georg Fuellen
Publié dans: bioRxiv, 2021
Éditeur: Cold Spring Harbot Laboratory
DOI: 10.1101/2021.04.08.439030

Pathway maps enable straightforward yet customized and semi-automated yet insightful analyses of omics data

Auteurs: Steffen Möller; Israel Barrantes; Robert Jaster; Larissa Henze; Hugo Murua Escobar; Christian Junghanß; Oliver W. Hakenberg; Marc-André Weber; Bernd J. Krause; Olaf Wolkenhauer; Saleh M. Ibrahim; Rüdiger Köhling; Falko Lange; Uwe Walter; Mohamed Hamed; Axel Kowald; Georg Fuellen
Publié dans: 2018
Éditeur: BopRxiv
DOI: 10.1101/404525

Western diet combined with rosmarinic acid in old mice exerts negative effects on metabolism but improves cognitive and emotional behaviour in a sex-dependent fashion

Auteurs: MUSILLO, CHIARA; POGGINI, SILVIA; Gaia De Cristofaro,; Kim, Zarse; Michael, Ristow; Bundy, Jacob G.; Virag, Sagi-Kiss; Karsten, Siems; Walter, Luyten; Alessandra, Berry; Francesca, Cirulli
Publié dans: Numéro 1, 2019
Éditeur: ISSS

Antioxidant N-acetyl-cysteine administration in pregnant mice has long-term positive effects on metabolic and behavioural endpoints of male and female offspring prenatally exposed to a high-fat-diet

Auteurs: Alessandra, Berry; Pamela, Panetta; Carla, Raggi; MUSILLO, CHIARA; Gaia De Cristofaro,; MAGNIFICO, MARIA CHIARA; ARESE, Marzia; Francesca, Cirulli
Publié dans: Numéro 1, 2018
Éditeur: 11th FENS Forum

Healthspan pathway maps in model organisms and human

Auteurs: Fuellen, Georg; Möller, Steffen; Saul, Nadine; Cirulli, Francesca; Jansen, Ludger; Antal, Peter; Luyten, Walter
Publié dans: 63. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); 20180902-20180906; Osnabrück; DOCAbstr. 153 /20180827/, Numéro 1, 2018
Éditeur: Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS)
DOI: 10.3205/18gmds162

Improving our understanding of sex-dependent mechanisms regulating healthspan through novel methodological approaches

Auteurs: Alessandra, Berry; Carla, Raggi; MUSILLO, CHIARA; Gaia De Cristofaro,; BRANCHI, Igor; POGGINI, SILVIA; Aurelia, Viglione; Francesca, Cirulli
Publié dans: 2018
Éditeur: 11th FENS Forum

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