Validating C. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Project website

Project website with public and (secure) consortium partition

Two compound patents filed

Two patents filed on plant extracts or compounds prolonging healthspan

Press release

D8.1: Press releases (M1 at occasion of kick-off, and upon major discoveries)

C. elegans reporter strains

Report and publication(s) on validated set of C. elegans reporter strains with reporters for all known healthspan pathways to permit quick assessment of candidate treatments

Compounds affecting healthspan in mice

Reports and publications on compounds affecting healthspan in mice

Book published

Book published in Springer series Health Ageing and Longevity M60

Mechanism of action

Reports and publications on compounds with molecular mechanism demonstrated to be similar in C. elegans and human cells

Validated healthspan polymorphisms

Report of validated polymorphisms predictive of better (or worse) health in the aged, stratified by sex and gender, and mapped onto pathways

Sex and gender dependency

Reports and publications on dependency on sex and gender of healthspan effects

Healthspan compounds

Reports and publications on compounds that prolong healthspan in C. elegans, and their mechanism of action

Non-pharmacological C. elegans models

Report and publication(s) on models for non-pharmacological treatments in C. elegans

Preparations with activity in mammalian cells

Report and submitted publication on individual compounds and complex extracts with health-promoting activity in relevant mammalian cellular assay.

Pubblicazioni

Trehalose administration in C57BL/6N old mice affects healthspan improving motor learning and brain anti-oxidant defences in a sex-dependent fashion: a pilot study

Autori: Alessandra Berry, Matteo Marconi, Chiara Musillo, Flavia Chiarotti, Veronica Bellisario, Paola Matarrese, Lucrezia Gambardella, Rosa Vona, Maria Lombardi, Chiara Foglieni, Francesca Cirulli
Pubblicato in: Experimental Gerontology, Numero 129, 2020, Pagina/e 110755, ISSN 0531-5565
Editore: Elsevier BV
DOI: 10.1016/j.exger.2019.110755

Search for Early Pancreatic Cancer Blood Biomarkers in Five European Prospective Population Biobanks Using Metabolomics

Autori: Jesse Fest, Lisanne S Vijfhuizen, Jelle J Goeman, Olga Veth, Anni Joensuu, Markus Perola, Satu Männistö, Eivind Ness-Jensen, Kristian Hveem, Toomas Haller, Neeme Tonisson, Kairit Mikkel, Andres Metspalu, Cornelia M van Duijn, Arfan Ikram, Bruno H Stricker, Rikje Ruiter, Casper H J van Eijck, Gert-Jan B van Ommen, Peter A C ʼt Hoen
Pubblicato in: Endocrinology, Numero 160/7, 2019, Pagina/e 1731-1742, ISSN 1945-7170
Editore: Oxford University Press
DOI: 10.1210/en.2019-00165

Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids

Autori: Steffen Möller, Nadine Saul, Alan A. Cohen, Rüdiger Köhling, Sina Sender, Hugo Murua Escobar, Christian Junghanss, Francesca Cirulli, Alessandra Berry, Peter Antal, Priit Adler, Jaak Vilo, Michele Boiani, Ludger Jansen, Dirk Repsilber, Hans Jörgen Grabe, Stephan Struckmann, Israel Barrantes, Mohamed Hamed, Brecht Wouters, Liliane Schoofs, Walter Luyten, Georg Fuellen
Pubblicato in: Aging, Numero 12/13, 2020, Pagina/e 12534-12581, ISSN 1945-4589
Editore: Impact Journals, LLC
DOI: 10.18632/aging.103514

Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation

Autori: Fei Yan, Qi Zhao, Huanpeng Gao, Xiaomei Wang, Ke Xu, Yishu Wang, Fuguo Han, Qingfei Liu, Yun Shi
Pubblicato in: Bioscience Reports, Numero 41/2, 2021, ISSN 0144-8463
Editore: Kluwer Academic Publishers
DOI: 10.1042/bsr20203955

Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A.

Autori: Leonid Rozanov; Meenakshi Ravichandran; Giovanna Grigolon; Maria Clara Zanellati; Johannes Mansfeld; Kim Zarse; Nir Barzilai; Gil Atzmon; Gil Atzmon; Fabian Fischer; Michael Ristow
Pubblicato in: Redox Biology, Numero 3, 2020, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.3929/ethz-b-000406666

Dynamic changes in p66Shc mRNA expression in peripheral blood mononuclear cells following resistance training intervention in old frail women born to obese mothers: a pilot study

Autori: Alessandra Berry, Marco Bucci, Carla Raggi, Johan G. Eriksson, Maria Angela Guzzardi, Pirjo Nuutila, Ville Huovinen, Patricia Iozzo, Francesca Cirulli
Pubblicato in: Aging Clinical and Experimental Research, Numero 30/7, 2018, Pagina/e 871-876, ISSN 1720-8319
Editore: Springer Verlag
DOI: 10.1007/s40520-017-0834-4

Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice

Autori: Gesine Reichart, Johannes Mayer, Cindy Zehm, Timo Kirschstein, Tursonjan Tokay, Falko Lange, Simone Baltrusch, Markus Tiedge, Georg Fuellen, Saleh Ibrahim, Rüdiger Köhling
Pubblicato in: Acta Physiologica, Numero 225/4, 2018, Pagina/e e13214, ISSN 1748-1708
Editore: Blackwell Publishing Inc.
DOI: 10.1111/apha.13214

Phytochemicals Rosmarinic Acid, Ampelopsin, and Amorfrutin-A Can Modulate Age-Related Phenotype of Serially Passaged Human Skin Fibroblasts in vitro

Autori: Lakshman Sodagam, Anna Lewinska, Ewa Kwasniewicz, Sofiya Kokhanovska, Maciej Wnuk, Karsten Siems, Suresh I. S. Rattan
Pubblicato in: Frontiers in Genetics, Numero 10, 2019, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2019.00081

Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways

Autori: Georg Fuellen, Ludger Jansen, Alan A Cohen, Walter Luyten, Manfred Gogol, Andreas Simm, Nadine Saul, Francesca Cirulli, Alessandra Berry, Peter Antal, Rüdiger Köhling, Brecht Wouters, Steffen Möller
Pubblicato in: Aging and disease, Numero 10/4, 2019, Pagina/e 883, ISSN 2152-5250
Editore: International Society on Aging and Disease
DOI: 10.14336/ad.2018.1030

Suppression of the TGF-β pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts in vitro

Autori: Thomas Stahnke, Beata Gajda-Deryło, Anselm G. Jünemann, Oliver Stachs, Katharina A. Sterenczak, Robert Rejdak, Julia Beck, Ekkehard Schütz, Steffen Möller, Israel Barrantes, Gregor Warsow, Stephan Struckmann, Georg Fuellen
Pubblicato in: Royal Society Open Science, Numero 7/9, 2020, Pagina/e 200441, ISSN 2054-5703
Editore: Royal Society
DOI: 10.1098/rsos.200441

Ample dietary fat reduced the risk of primary vesical calculi by inducing macrophages to engulf budding crystals in mice

Autori: Huiling Chen, Kaiqiang Hu, Yaru Liang, Yuqi Gao, Chenye Zeng, Kang Xu, Xiaojin Shi, Liyuan Li, Yuemiao Yin, Yi Qiao, Ying Qiu, Qingfei Liu, Zhao Wang
Pubblicato in: Acta Pharmaceutica Sinica B, 2021, ISSN 2211-3835
Editore: Elsevier B.V.
DOI: 10.1016/j.apsb.2021.08.001

Enhanced Healthspan in Caenorhabditis elegans Treated With Extracts From the Traditional Chinese Medicine Plants Cuscuta chinensis Lam. and Eucommia ulmoides Oliv.

Autori: Shimaa M. A. Sayed, Karsten Siems, Christian Schmitz-Linneweber, Walter Luyten, Nadine Saul
Pubblicato in: Frontiers in Pharmacology, Numero 12, 2021, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.604435

The nutritional requirements of Caenorhabditis elegans

Autori: Aleksandra Zečić, Ineke Dhondt, Bart P. Braeckman
Pubblicato in: Genes & Nutrition, Numero 14/1, 2019, ISSN 1555-8932
Editore: New Century Health Publishers
DOI: 10.1186/s12263-019-0637-7

FocusHeuristics – expression-data-driven network optimization and disease gene prediction

Autori: Mathias Ernst, Yang Du, Gregor Warsow, Mohamed Hamed, Nicole Endlich, Karlhans Endlich, Hugo Murua Escobar, Lisa-Madeleine Sklarz, Sina Sender, Christian Junghanß, Steffen Möller, Georg Fuellen, Stephan Struckmann
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep42638

Chronic exposure to rapamycin and episodic serum starvation modulate ageing of human fibroblasts in vitro

Autori: Lakshman Sodagam, Anna Lewinska, Maciej Wnuk, Suresh I. S. Rattan
Pubblicato in: Biogerontology, Numero 18/5, 2017, Pagina/e 841-854, ISSN 1389-5729
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10522-017-9730-8

Manhattan Harvester and Cropper: a system for GWAS peak detection

Autori: Toomas Haller, Tõnis Tasa, Andres Metspalu
Pubblicato in: BMC Bioinformatics, Numero 20/1, 2019, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-019-2600-4

Optimized criteria for locomotion-based healthspan evaluation in C. elegans using the WorMotel system

Autori: Areta Jushaj, Matthew Churgin, Bowen Yao, Miguel De La Torre, Christopher Fang-Yen, Liesbet Temmerman
Pubblicato in: PLOS ONE, Numero 15/3, 2020, Pagina/e e0229583, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0229583

Healthspan Maintenance and Prevention of Parkinson’s-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans

Autori: Giovanni Brunetti, Gabriele Di Rosa, Maria Scuto, Manuela Leri, Massimo Stefani, Christian Schmitz-Linneweber, Vittorio Calabrese, Nadine Saul
Pubblicato in: International Journal of Molecular Sciences, Numero 21/7, 2020, Pagina/e 2588, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072588

Single-cell analyses of aging, inflammation and senescence

Autori: Bora Uyar, Daniel Palmer, Axel Kowald, Hugo Murua Escobar, Israel Barrantes, Steffen Möller, Altuna Akalin, Georg Fuellen
Pubblicato in: Ageing Research Reviews, Numero 64, 2020, Pagina/e 101156, ISSN 1568-1637
Editore: Elsevier BV
DOI: 10.1016/j.arr.2020.101156

Biphasic Dose–Response and Hormetic Effects of Stress Hormone Hydrocortisone on Telomerase-Immortalized Human Bone Marrow Stem Cells In Vitro

Autori: Indra Kumar Gopi, Suresh I. S. Rattan
Pubblicato in: Dose-Response, Numero 17/4, 2019, Pagina/e 155932581988981, ISSN 1559-3258
Editore: International Dose-Response Society
DOI: 10.1177/1559325819889819

Scoring functions for drug-effect similarity

Autori: Stephan Struckmann, Mathias Ernst, Sarah Fischer, Nancy Mah, Georg Fuellen, Steffen Möller
Pubblicato in: Briefings in Bioinformatics, Numero 22/3, 2021, ISSN 1467-5463
Editore: Oxford University Press
DOI: 10.1093/bib/bbaa072

Genes implicated in Caenorhabditis elegans and human health regulate stress resistance and physical abilities in aged Caenorhabditis elegans

Autori: Jessica Dysarz, Georg Fuellen, Steffen Möller, Walter Luyten, Christian Schmitz-Linneweber, Nadine Saul
Pubblicato in: Biology Letters, Numero 17/6, 2021, Pagina/e 20200916, ISSN 1744-957X
Editore: Royal Society
DOI: 10.1098/rsbl.2020.0916

Prediction of biological age by morphological staging of sarcopenia in Caenorhabditis elegans

Autori: Ineke Dhondt, Clara Verschuuren, Aleksandra Zečić , Tim Loier, Bart P. Braeckman, Winnok H. De Vos
Pubblicato in: Disease Models & Mechanisms, 2021, ISSN 1754-8411
Editore: The Company of Biologists Ltd
DOI: 10.1242/dmm.049169

Administration of the Antioxidant N-Acetyl-Cysteine in Pregnant Mice Has Long-Term Positive Effects on Metabolic and Behavioral Endpoints of Male and Female Offspring Prenatally Exposed to a High-Fat Diet

Autori: Alessandra Berry, Veronica Bellisario, Pamela Panetta, Carla Raggi, Maria C. Magnifico, Marzia Arese, Francesca Cirulli
Pubblicato in: Frontiers in Behavioral Neuroscience, Numero 12, 2018, ISSN 1662-5153
Editore: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2018.00048

The genetic predisposition to longevity acts through behavioral phenotypes in females

Autori: Sandra Van der Auwera, Linda Garvert, Georg Fuellen, Matthias Nauck, Henry Völzke, Uwe Völker, Hans J. Grabe
Pubblicato in: European Neuropsychopharmacology, Numero 45, 2021, Pagina/e 1-14, ISSN 0924-977X
Editore: Elsevier BV
DOI: 10.1016/j.euroneuro.2021.02.014

Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India

Autori: Sujogya Kumar Panda, Walter Luyten
Pubblicato in: Parasite, Numero 25, 2018, Pagina/e 10, ISSN 1776-1042
Editore: EDP Sciences
DOI: 10.1051/parasite/2018008

The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice

Autori: Huiling Chen, Qing Huang, Shunjia Zhang, Kaiqiang Hu, Wenxiang Xiong, Lingyun Xiao, Renhuai Cong, Qingfei Liu, Zhao Wang
Pubblicato in: Nutrients, Numero 11/4, 2019, Pagina/e 859, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu11040859

In vitro aggregating β-lactamase-polyQ chimeras do not induce toxic effects in an in vivo Caenorhabditis elegans model

Autori: Roel Van Assche; Charline Borghgraef; Jonathan Vaneyck; Mireille Dumoulin; Liliane Schoofs; Liesbet Temmerman
Pubblicato in: Journal of Negative Results in Biomedicine, Numero 6, 2017, Pagina/e 1-14, ISSN 1477-5751
Editore: BioMed Central
DOI: 10.1186/s12952-017-0080-5

Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson’s Models

Autori: Gabriele Di Rosa, Giovanni Brunetti, Maria Scuto, Angela Trovato Salinaro, Edward J. Calabrese, Roberto Crea, Christian Schmitz-Linneweber, Vittorio Calabrese, Nadine Saul
Pubblicato in: International Journal of Molecular Sciences, Numero 21/11, 2020, Pagina/e 3893, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21113893

Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing

Autori: Georg Fuellen, Paul Schofield, Thomas Flatt, Ralf-Joachim Schulz, Fritz Boege, Karin Kraft, Gerald Rimbach, Saleh Ibrahim, Alexander Tietz, Christian Schmidt, Rüdiger Köhling, Andreas Simm
Pubblicato in: Gerontology, Numero 62/4, 2016, Pagina/e 409-416, ISSN 0304-324X
Editore: S. Karger AG
DOI: 10.1159/000442746

Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone

Autori: Daniela Ohde, Mark Moeller, Julia Brenmoehl, Christina Walz, Siriluck Ponsuksili, Manfred Schwerin, Georg Fuellen, Andreas Hoeflich
Pubblicato in: PLOS ONE, Numero 11/1, 2016, Pagina/e e0146748, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0146748

Ageing with elegans: a research proposal to map healthspan pathways

Autori: Walter Luyten, Peter Antal, Bart P. Braeckman, Jake Bundy, Francesca Cirulli, Christopher Fang-Yen, Georg Fuellen, Armand Leroi, Qingfei Liu, Patricia Martorell, Andres Metspalu, Markus Perola, Michael Ristow, Nadine Saul, Liliane Schoofs, Karsten Siems, Liesbet Temmerman, Tina Smets, Alicja Wolk, Suresh I. S. Rattan
Pubblicato in: Biogerontology, Numero 17/4, 2016, Pagina/e 771-782, ISSN 1389-5729
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10522-016-9644-x

ClonoCalc and ClonoPlot: immune repertoire analysis from raw files to publication figures with graphical user interface

Autori: Anke Fähnrich; Moritz Krebbel; Normann Decker; Martin Leucker; Felix D. Lange; Kathrin Kalies; Steffen Möller
Pubblicato in: BMC Bioinformatics, Numero 3, 2017, Pagina/e 1-6, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-017-1575-2

Maternal Obesity as a Risk Factor for Brain Development and Mental Health in the Offspring

Autori: Francesca Cirulli, Chiara Musillo, Alessandra Berry
Pubblicato in: Neuroscience, Numero 447, 2020, Pagina/e 122-135, ISSN 0306-4522
Editore: Elsevier BV
DOI: 10.1016/j.neuroscience.2020.01.023

Curcuma Longa, the “Golden Spice” to Counteract Neuroinflammaging and Cognitive Decline—What Have We Learned and What Needs to Be Done

Autori: Alessandra Berry, Barbara Collacchi, Roberta Masella, Rosaria Varì, Francesca Cirulli
Pubblicato in: Nutrients, Numero 13/5, 2021, Pagina/e 1519, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13051519

Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies

Autori: Nadine Saul, Steffen Möller, Francesca Cirulli, Alessandra Berry, Walter Luyten, Georg Fuellen
Pubblicato in: Biogerontology, Numero 22/2, 2021, Pagina/e 215-236, ISSN 1389-5729
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10522-021-09913-2

Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss

Autori: Heikki V. Sarin, Ivan Gudelj, Jarno Honkanen, Johanna K. Ihalainen, Arja Vuorela, Joseph H. Lee, Zhenzhen Jin, Joseph D. Terwilliger, Ville Isola, Juha P. Ahtiainen, Keijo Häkkinen, Julija Jurić, Gordan Lauc, Kati Kristiansson, Juha J. Hulmi, Markus Perola
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2019.00907

Comparison of cytokine/chemokine levels in aqueous humor of primary open-angle glaucoma patients with positive or negative outcome following trabeculectomy

Autori: Beata Gajda-Deryło; Thomas Stahnke; Stephan Struckmann; Gregor Warsow; Kerstin Birke; Marco T. Birke; Bettina Hohberger; Robert Rejdak; Georg Fuellen; Anselm G. Jünemann
Pubblicato in: Bioscience reports, Numero 4, 2019, Pagina/e 1-11, ISSN 1573-4935
Editore: Portland PRess
DOI: 10.1042/bsr20181894

Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves

Autori: Yaru Liang, Chang Liu, Maoyang Lu, Qiongye Dong, Zimu Wang, Zhuoran Wang, Wenxiang Xiong, Nannan Zhang, Jiawei Zhou, Qingfei Liu, Xiaowo Wang, Zhao Wang
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-24146-z

Exploring neuropeptide signalling through proteomics and peptidomics

Autori: Samantha Louise Edwards, Lucas Mergan, Bhavesh Parmar, Bram Cockx, Wouter De Haes, Liesbet Temmerman, Liliane Schoofs
Pubblicato in: Expert Review of Proteomics, Numero 16/2, 2019, Pagina/e 131-137, ISSN 1478-9450
Editore: Future Drugs Ltd.
DOI: 10.1080/14789450.2019.1559733

Robust Cross-Platform Workflows: How Technical and Scientific Communities Collaborate to Develop, Test and Share Best Practices for Data Analysis

Autori: Steffen Möller, Stuart W. Prescott, Lars Wirzenius, Petter Reinholdtsen, Brad Chapman, Pjotr Prins, Stian Soiland-Reyes, Fabian Klötzl, Andrea Bagnacani, Matúš Kalaš, Andreas Tille, Michael R. Crusoe
Pubblicato in: Data Science and Engineering, Numero 2/3, 2017, Pagina/e 232-244, ISSN 2364-1185
Editore: Springer Verlag
DOI: 10.1007/s41019-017-0050-4

Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder

Autori: Zhuoran Wang, Yaru Liang, Lu Zhang, Nannan Zhang, Qingfei Liu, Zhao Wang
Pubblicato in: Aging, Numero 10/9, 2018, Pagina/e 2394-2406, ISSN 1945-4589
Editore: Impact Journals, LLC
DOI: 10.18632/aging.101559

The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging)

Autori: Georg Fuellen, Oliver Liesenfeld, Axel Kowald, Israel Barrantes, Manuela Bastian, Andreas Simm, Ludger Jansen, Alexander Tietz-Latza, Dagmar Quandt, Claudio Franceschi, Michael Walter
Pubblicato in: Ageing Research Reviews, Numero 62, 2020, Pagina/e 101091, ISSN 1568-1637
Editore: Elsevier BV
DOI: 10.1016/j.arr.2020.101091

Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging

Autori: Matthew A Churgin, Sang-Kyu Jung, Chih-Chieh Yu, Xiangmei Chen, David M Raizen, Christopher Fang-Yen
Pubblicato in: eLife, Numero 6, 2017, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.26652

Long-Term Sex-Dependent Vulnerability to Metabolic challenges in Prenatally Stressed Rats

Autori: Pamela Panetta, Alessandra Berry, Veronica Bellisario, Sara Capoccia, Carla Raggi, Alessia Luoni, Linda Longo, Marco A. Riva, Francesca Cirulli
Pubblicato in: Frontiers in Behavioral Neuroscience, Numero 11, 2017, ISSN 1662-5153
Editore: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2017.00113

Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis

Autori: Chiara Musillo, Marta Borgi, Nadine Saul, Steffen Möller, Walter Luyten, Alessandra Berry, Francesca Cirulli
Pubblicato in: Neuroscience & Biobehavioral Reviews, Numero 121, 2021, Pagina/e 89-105, ISSN 0149-7634
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.12.001

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation

Autori: Nath Artika P; Ritchie Scott C; Byars Sean G; Fearnley Liam G; Havulinna Aki S; Joensuu Anni; Kangas Antti J; Soininen Pasi; Wennerström Annika; Milani Lili; Metspalu Andres; Männistö Satu; Würtz Peter; Kettunen Johannes; Raitoharju Emma; Kähönen Mika; Juonala Markus; Palotie Aarno; Ala-Korpela Mika; Ripatti Samuli et al.
Pubblicato in: Genome Biology, Numero 3, 2017, ISSN 1474-760X
Editore: Springer Verlag
DOI: 10.1186/s13059-017-1279-y

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Autori: Misa Hirose, Paul Schilf, Yask Gupta, Kim Zarse, Axel Künstner, Anke Fähnrich, Hauke Busch, Junping Yin, Marvin N. Wright, Andreas Ziegler, Marie Vallier, Meriem Belheouane, John F Baines, Diethard Tautz, Kornelia Johann, Rebecca Oelkrug, Jens Mittag, Hendrik Lehnert, Alaa Othman, Olaf Jöhren, Markus Schwaninger, Cornelia Prehn, Jerzy Adamski, Kensuke Shima, Jan Rupp, Robert Häsler, Georg Fuel
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-24290-6

Plant-Derived Molecules α-Boswellic Acid Acetate, Praeruptorin-A, and Salvianolic Acid-B Have Age-Related Differential Effects in Young and Senescent Human Fibroblasts In Vitro

Autori: Anna Lewinska, Lakshman Sodagam, Dominika Bloniarz, Karsten Siems, Maciej Wnuk, Suresh I. S. Rattan
Pubblicato in: Molecules, Numero 25/1, 2020, Pagina/e 141, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25010141

Combination of mitochondrial tRNA and OXPHOS mutation reduces lifespan and physical condition in aged mice

Autori: Gesine Reichart; Johannes Mayer; Tursonjan Tokay; Falko Lange; C Johne; Simone Baltrusch; Markus Tiedge; Georg Fuellen; Saleh M. Ibrahim; Rüdiger Köhling
Pubblicato in: Numero 1, 2017
Editore: bioRxiv
DOI: 10.1101/233593

Royalactin induces copious longevity via increased translation and proteasome activity in C. elegans

Autori: Detienne, Giel; Van de Walle, Pieter; De Haes, Wouter; Cockx, Bram; Braeckman, Bart P.; Schoofs, Liliane; Temmerman, Liesbet
Pubblicato in: Numero 2, 2018
Editore: BioRxiv

Gene co-expression analyses of health(span) across multiple species

Autori: Steffen Möller, Nadine Saul, Israel Barrantes, András Gézsi, Michael Walter, Péter Antal, Georg Fuellen
Pubblicato in: bioRxiv, 2021
Editore: Cold Spring Harbot Laboratory
DOI: 10.1101/2021.04.08.439030

Pathway maps enable straightforward yet customized and semi-automated yet insightful analyses of omics data

Autori: Steffen Möller; Israel Barrantes; Robert Jaster; Larissa Henze; Hugo Murua Escobar; Christian Junghanß; Oliver W. Hakenberg; Marc-André Weber; Bernd J. Krause; Olaf Wolkenhauer; Saleh M. Ibrahim; Rüdiger Köhling; Falko Lange; Uwe Walter; Mohamed Hamed; Axel Kowald; Georg Fuellen
Pubblicato in: 2018
Editore: BopRxiv
DOI: 10.1101/404525

Western diet combined with rosmarinic acid in old mice exerts negative effects on metabolism but improves cognitive and emotional behaviour in a sex-dependent fashion

Autori: MUSILLO, CHIARA; POGGINI, SILVIA; Gaia De Cristofaro,; Kim, Zarse; Michael, Ristow; Bundy, Jacob G.; Virag, Sagi-Kiss; Karsten, Siems; Walter, Luyten; Alessandra, Berry; Francesca, Cirulli
Pubblicato in: Numero 1, 2019
Editore: ISSS

Antioxidant N-acetyl-cysteine administration in pregnant mice has long-term positive effects on metabolic and behavioural endpoints of male and female offspring prenatally exposed to a high-fat-diet

Autori: Alessandra, Berry; Pamela, Panetta; Carla, Raggi; MUSILLO, CHIARA; Gaia De Cristofaro,; MAGNIFICO, MARIA CHIARA; ARESE, Marzia; Francesca, Cirulli
Pubblicato in: Numero 1, 2018
Editore: 11th FENS Forum

Healthspan pathway maps in model organisms and human

Autori: Fuellen, Georg; Möller, Steffen; Saul, Nadine; Cirulli, Francesca; Jansen, Ludger; Antal, Peter; Luyten, Walter
Pubblicato in: 63. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); 20180902-20180906; Osnabrück; DOCAbstr. 153 /20180827/, Numero 1, 2018
Editore: Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS)
DOI: 10.3205/18gmds162

Improving our understanding of sex-dependent mechanisms regulating healthspan through novel methodological approaches

Autori: Alessandra, Berry; Carla, Raggi; MUSILLO, CHIARA; Gaia De Cristofaro,; BRANCHI, Igor; POGGINI, SILVIA; Aurelia, Viglione; Francesca, Cirulli
Pubblicato in: 2018
Editore: 11th FENS Forum

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