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Point-of-care microfluidic device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection

Obiettivo

The decision-making in chemotherapy nowadays depends on standard methods that are liquid chromatography (LC-MS/MS) followed by mass spectrometry or capillary electrophoresis; both are labour- and cost-intensive and can be performed only in dedicated hospitals and laboratories. This lead to a minimal therapeutic drug monitoring in patients and hence that 30-60% of drugs are administered without clinical benefits.

We propose to develop a point-of-care device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection incorporated in microfluidic lab-on-chip device (optofluidics based) allowing the real-time drug monitoring. This will improve the therapeutic outcome and reduced health care costs.

Campo scientifico (EuroSciVoc)

Parole chiave

Programma(i)

Argomento(i)

Meccanismo di finanziamento

RIA - Research and Innovation action

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Invito a presentare proposte

(si apre in una nuova finestra) H2020-PHC-2014-2015

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Coordinatore

ENTE OSPEDALIERO SAVERIO DE BELLIS IRCCS
Contributo netto dell'UE
€ 293 636,40
Indirizzo
VIA TURI 27
70013 CASTELLANA GROTTE BA
Italia
Regione
Centro (IT) Lazio Roma
Tipo di attività
Research Organisations
Collegamenti
Costo totale
€ 293 636,40

Partecipanti (10)