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Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes

Obiettivo

Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast cancer. Given that breast cancer is not one disease, it is now essential to better understand how risk factors act together to influence the development of pathologic-molecular subtypes of breast cancer.
The aim of B-CAST is to identify women at moderate to high risk of breast cancer, the subtype of cancer that is most likely to develop and the prognosis of that particular subtype. This will be accomplished through large-scale pathologic-molecular analyses of over 20,000 breast tumours, and the integration of these data with unique resources from existing consortia, including germline, lifestyle/environmental, mammographic breast density, pathologic and clinical data. This information will inform the development of risk prediction and prognostication models that will be validated in longitudinal cohorts and clinical studies, and incorporated into online tools. We will also disseminate this knowledge to relevant stakeholders, and evaluate how to translate it into risk-stratified public health and clinical strategies.
The current challenge for optimised prevention, early detection, and treatment decisions for breast cancer is understanding the genetic and lifestyle determinants of risk and prognosis of molecular subtypes. B-CAST will add to this understanding and will have immediate application with benefits to women by providing validated risk and prognostication tools. This will empower women and doctors with knowledge to tailor strategies for prevention and treatment. Ultimately, this work should result in reductions in the occurrence, morbidity and mortality of this disease.

Invito a presentare proposte

H2020-PHC-2014-2015

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Bando secondario

H2020-PHC-2014-two-stage

Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Contribution nette de l'UE
€ 925 687,50
Indirizzo
Plesmanlaan 121
1066 CX Amsterdam
Paesi Bassi

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Regione
West-Nederland Noord-Holland Groot-Amsterdam
Tipo di attività
Research Organisations
Contributo di paesi terzi
€ 0,00

Partecipanti (12)

THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
United Kingdom
Contribution nette de l'UE
€ 383 306,25
Indirizzo
Old Brompton Road 123
SW7 3RP London

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Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Contribution nette de l'UE
€ 1 056 118,75
Indirizzo
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Regione
East of England East Anglia Cambridgeshire CC
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00
KAROLINSKA INSTITUTET
Svezia
Contribution nette de l'UE
€ 350 000,00
Indirizzo
Nobels Vag 5
17177 Stockholm

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Regione
Östra Sverige Stockholm Stockholms län
Tipo di attività
Higher or Secondary Education Establishments
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€ 0,00
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germania
Contribution nette de l'UE
€ 268 750,00
Indirizzo
Im Neuenheimer Feld 280
69120 Heidelberg

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Regione
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Tipo di attività
Research Organisations
Contributo di paesi terzi
€ 0,00
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spagna
Contribution nette de l'UE
€ 399 000,00
Indirizzo
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela

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Regione
Galicia A Coruña
Tipo di attività
Higher or Secondary Education Establishments
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€ 0,00
FUNDACIO PARC CIENTIFIC DE BARCELONA

Partecipazione conclusa

Spagna
Contribution nette de l'UE
€ 0,00
Contributo di paesi terzi
€ 0,00
VIB VZW
Belgio
Contribution nette de l'UE
€ 63 750,00
Indirizzo
Rijvisschestraat 120
9052 Zwijnaarde - Gent

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Regione
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
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Research Organisations
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€ 0,00
FOUNDATION FOR GENOMICS & POPULATION HEALTH
United Kingdom
Contribution nette de l'UE
€ 228 618,75
Indirizzo
Worts Causeway 2
CB1 8RN Cambridge

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Regione
East of England East Anglia Cambridgeshire CC
Tipo di attività
Research Organisations
Contributo di paesi terzi
€ 0,00
UNIVERSITE LAVAL
Canada
Contribution nette de l'UE
€ 0,00
Indirizzo
Allee Des Bibliotheques 2345
G1V 0A6 Quebec

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Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 37 500,00
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
Australia
Contribution nette de l'UE
€ 0,00
Contributo di paesi terzi
€ 37 500,00
HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC.
Stati Uniti
Contribution nette de l'UE
€ 0,00
Indirizzo
Office Of The General Counsel, Holyoke Center, Suite 980, Massachusetts Avenue 1350
02138 Cambridge

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Research Organisations
Contributo di paesi terzi
€ 62 500,00
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spagna
Contribution nette de l'UE
€ 2 308 125,00
Indirizzo
Carrer Doctor Aiguader 88
08003 Barcelona

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Regione
Este Cataluña Barcelona
Tipo di attività
Research Organisations
Contributo di paesi terzi
€ 0,00