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Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes

Obiettivo

Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast cancer. Given that breast cancer is not one disease, it is now essential to better understand how risk factors act together to influence the development of pathologic-molecular subtypes of breast cancer.
The aim of B-CAST is to identify women at moderate to high risk of breast cancer, the subtype of cancer that is most likely to develop and the prognosis of that particular subtype. This will be accomplished through large-scale pathologic-molecular analyses of over 20,000 breast tumours, and the integration of these data with unique resources from existing consortia, including germline, lifestyle/environmental, mammographic breast density, pathologic and clinical data. This information will inform the development of risk prediction and prognostication models that will be validated in longitudinal cohorts and clinical studies, and incorporated into online tools. We will also disseminate this knowledge to relevant stakeholders, and evaluate how to translate it into risk-stratified public health and clinical strategies.
The current challenge for optimised prevention, early detection, and treatment decisions for breast cancer is understanding the genetic and lifestyle determinants of risk and prognosis of molecular subtypes. B-CAST will add to this understanding and will have immediate application with benefits to women by providing validated risk and prognostication tools. This will empower women and doctors with knowledge to tailor strategies for prevention and treatment. Ultimately, this work should result in reductions in the occurrence, morbidity and mortality of this disease.

Invito a presentare proposte

H2020-PHC-2014-two-stage
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Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Indirizzo
Plesmanlaan 121
1066 CX Amsterdam
Paesi Bassi
Tipo di attività
Research Organisations
Contributo UE
€ 925 687,50

Partecipanti (12)

THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
United Kingdom
Contributo UE
€ 383 306,25
Indirizzo
Old Brompton Road 123
SW7 3RP London
Tipo di attività
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Contributo UE
€ 1 056 118,75
Indirizzo
Trinity Lane The Old Schools
CB2 1TN Cambridge
Tipo di attività
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Svezia
Contributo UE
€ 350 000
Indirizzo
Nobels Vag 5
17177 Stockholm
Tipo di attività
Higher or Secondary Education Establishments
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germania
Contributo UE
€ 268 750
Indirizzo
Im Neuenheimer Feld 280
69120 Heidelberg
Tipo di attività
Research Organisations
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spagna
Contributo UE
€ 399 000
Indirizzo
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela
Tipo di attività
Higher or Secondary Education Establishments
FUNDACIO PARC CIENTIFIC DE BARCELONA

Partecipazione conclusa

Spagna
Contributo UE
€ 0
Indirizzo
Baldiri I Reixac 4
08028 Barcelona
Tipo di attività
Research Organisations
VIB VZW
Belgio
Contributo UE
€ 63 750
Indirizzo
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Tipo di attività
Research Organisations
FOUNDATION FOR GENOMICS & POPULATION HEALTH
United Kingdom
Contributo UE
€ 228 618,75
Indirizzo
Worts Causeway 2
CB1 8RN Cambridge
Tipo di attività
Research Organisations
UNIVERSITE LAVAL
Canada
Contributo UE
€ 0
Indirizzo
Allee Des Bibliotheques 2345
G1V 0A6 Quebec
Tipo di attività
Higher or Secondary Education Establishments
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
Australia
Contributo UE
€ 0
Indirizzo
Herston Road, 300
QLD 4006 Herston
Tipo di attività
Research Organisations
HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC.
Stati Uniti
Contributo UE
€ 0
Indirizzo
Office Of The General Counsel, Holyoke Center, Suite 980, Massachusetts Avenue 1350
02138 Cambridge
Tipo di attività
Research Organisations
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spagna
Contributo UE
€ 2 308 125
Indirizzo
Carrer Doctor Aiguader 88
08003 Barcelona
Tipo di attività
Research Organisations