Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes

Livrables

D8.2 Report of International Force Field analysis workshop and identification of key areas for strategy development

Report of International Force Field analysis workshop and identification of key areas for strategy development

D1.5 End-term meeting together with BRIDGES

Endterm meeting together with BRIDGESDelay due to COVID19 Due date to be moved to M66 BCAST planned deliverable D15 together with BRIDGES from 26th29th June 2020 in Leiden which has been cancelled due to the COVID19 crisis The purpose of the meeting was to disseminate the results of both BCAST and BRIDGES to the wider scientific community as the two consortia have worked synergistically for the last 5 years As the possibility of holding a physical meeting by Feb 2021 still appears slim we hope to get a further 6 month extension to be able to organise the meeting at a later point next year

D4.2 Description of database for mammographic density

Description of database for mammographic density

D3.1 List of genes in panel for targeted DNA sequencing

List of genes in panel for targeted DNA sequencing

D4.1 Description of database for environmental risk factors

Description of database for environmental risk factors

D1.2 Final report on successfully performed communication, dissemination, exploitation activities.

Final report on successfully performed communication dissemination exploitation activitiesDelay due to COVID19 due date to be moved to M66 We were making steady progress with milestones and deliverables from WP2 MS 23 MS 24 D23 and WP3 MS 3235 D32 which were delayed previously as reported in RP2 also indicated in this table below Due to the sudden reduction in lab capacities as the COVID19 crisis evolved some parts of the final analyses on the TMAs for WP2 D23 and about 1000 samples still remain to be sequenced at CNAG MS34 consequently on MS35 and D32 which was otherwise expected to be completed by midApril 2020 With the requested extension we will be able to complete our target of generating new genomic information based on IHCISH panels on 25873 tumours and targeted sequencing on a subset of 10000 tumours that will inform risk and prognosis modelling of breast cancer Additionally we can then include these analyses in our manuscripts which will play a key role in informing the scientific community about our results

D4.3 Description of genotyping database

Description of genotyping database

D8.1 Report on current public health and policy discourses on personalised breast cancer prevention

Report on current public health and policy discourses on personalised breast cancer prevention

D8.3 Final report on personalised breast cancer prevention aimed at public health professionals and policy makers

Final report on personalised breast cancer prevention aimed at public health professionals and policy makers

D7.1 Web-tool (in English) that predicts overall breast cancer risk and the risks for breast cancer subtypes

Webtool in English that predicts overall breast cancer risk and the risks for breast cancer subtypes

D1.1. Website for internal and external communication

Website for internal and external communication Note dissemination level: some parts of the website will only be for project members (CO)

D7.3 Translated versions of the risk prediction and prognosis tools in other languages

Translated versions of the risk prediction and prognosis tools in other languages

D7.2 Web-tool (in English) that predicts survival after a breast cancer diagnosis

Webtool in English that predicts survival after a breast cancer diagnosis

Publications

Identification of Women at High Risk of Breast Cancer Who Need Supplemental Screening

Auteurs: Mikael Eriksson, Kamila Czene, Fredrik Strand, Sophia Zackrisson, Peter Lindholm, Kristina Lång, Daniel Förnvik, Hanna Sartor, Nasim Mavaddat, Doug Easton, Per Hall
Publié dans: Radiology, Numéro 297/2, 2020, Page(s) 327-333, ISSN 0033-8419
Éditeur: Radiological Society of North America
DOI: 10.1148/radiol.2020201620

Predictors of mammographic microcalcifications

Auteurs: Shadi Azam, Mikael Eriksson, Arvid Sjölander, Marike Gabrielson, Roxanna Hellgren, Kamila Czene, Per Hall
Publié dans: International Journal of Cancer, Numéro 148/5, 2021, Page(s) 1132-1143, ISSN 0020-7136
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ijc.33302

CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Auteurs: Nichola Johnson, Sarah Maguire, Anna Morra, Pooja Middha Kapoor, Katarzyna Tomczyk, Michael E. Jones, Minouk J. Schoemaker, Clare Gilham, Manjeet K. Bolla, Qin Wang, Joe Dennis, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Caroline Baynes, Laura E. Beane Freeman, Matthias W. Beckmann, Javier Benitez, Marina
Publié dans: British Journal of Cancer, Numéro 124/4, 2021, Page(s) 842-854, ISSN 0007-0920
Éditeur: Nature Publishing Group
DOI: 10.1038/s41416-020-01185-w

Comparative validation of the BOADICEA and Tyrer-Cuzick breast cancer risk models incorporating classical risk factors and polygenic risk in a population-based prospective cohort of women of European ancestry

Auteurs: Parichoy Pal Choudhury, Mark N. Brook, Amber N. Hurson, Andrew Lee, Charlotta V. Mulder, Penny Coulson, Minouk J. Schoemaker, Michael E. Jones, Anthony J. Swerdlow, Nilanjan Chatterjee, Antonis C. Antoniou, Montserrat Garcia-Closas
Publié dans: Breast Cancer Research, Numéro 23/1, 2021, ISSN 1465-542X
Éditeur: BMC Springer Nature
DOI: 10.1186/s13058-021-01399-7

Personalized early detection and prevention of breast cancer: ENVISION consensus statement

Auteurs: Nora Pashayan, Antonis C. Antoniou, Urska Ivanus, Laura J. Esserman, Douglas F. Easton, David French, Gaby Sroczynski, Per Hall, Jack Cuzick, D. Gareth Evans, Jacques Simard, Montserrat Garcia-Closas, Rita Schmutzler, Odette Wegwarth, Paul Pharoah, Sowmiya Moorthie, Sandrine De Montgolfier, Camille Baron, Zdenko Herceg, Clare Turnbull, Corinne Balleyguier, Paolo Giorgi Rossi, Jelle Wesseling, Davi
Publié dans: Nature Reviews Clinical Oncology, Numéro 17/11, 2020, Page(s) 687-705, ISSN 1759-4774
Éditeur: Nature Publishing Group
DOI: 10.1038/s41571-020-0388-9

CanRisk Tool—A Web Interface for the Prediction of Breast and Ovarian Cancer Risk and the Likelihood of Carrying Genetic Pathogenic Variants

Auteurs: Tim Carver, Simon Hartley, Andrew Lee, Alex P. Cunningham, Stephanie Archer, Chantal Babb de Villiers, Jonathan Roberts, Rod Ruston, Fiona M. Walter, Marc Tischkowitz, Douglas F. Easton, Antonis C. Antoniou
Publié dans: Cancer Epidemiology Biomarkers & Prevention, Numéro 30/3, 2021, Page(s) 469-473, ISSN 1055-9965
Éditeur: American Association for Cancer Research
DOI: 10.1158/1055-9965.epi-20-1319

Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk

Auteurs: Pooja Middha Kapoor, Nasim Mavaddat, Parichoy Pal Choudhury, Amber N Wilcox, Sara Lindström, Sabine Behrens, Kyriaki Michailidou, Joe Dennis, Manjeet K Bolla, Qin Wang, Audrey Jung, Zomoroda Abu-Ful, Thomas Ahearn, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Paul L Auer, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Lesl
Publié dans: JNCI: Journal of the National Cancer Institute, Numéro 113/3, 2020, Page(s) 329-337, ISSN 0027-8874
Éditeur: Oxford University Press
DOI: 10.1093/jnci/djaa056

Prospective evaluation of a breast-cancer risk model integrating classical risk factors and polygenic risk in 15 cohorts from six countries

Auteurs: Amber N Hurson, Parichoy Pal Choudhury, Chi Gao, Anika Hüsing, Mikael Eriksson, Min Shi, Michael E Jones, D Gareth R Evans, Roger L Milne, Mia M Gaudet, Celine M Vachon, Daniel I Chasman, Douglas F Easton, Marjanka K Schmidt, Peter Kraft, Montserrat Garcia-Closas, Nilanjan Chatterjee, Christopher G Scott, Brian D Carter, Kara Martin, Elaine F Harkness, Mark N Brook, Thomas U Ahearn, Nasim Mavadda
Publié dans: International Journal of Epidemiology, 2021, ISSN 0300-5771
Éditeur: Oxford University Press
DOI: 10.1093/ije/dyab036

Breast Cancer Risk Genes — Association Analysis in More than 113,000 Women

Auteurs: Leila Dorling, Sara Carvalho, Jamie Allen, Anna González-Neira, Craig Luccarini, Cecilia Wahlström, Karen A. Pooley, Michael T. Parsons, Cristina Fortuno, Qin Wang, Manjeet K. Bolla, Joe Dennis, Renske Keeman, M. Rosario Alonso, Nuria Álvarez, Belen Herraez, Victoria Fernandez, Rocio Núñez-Torres, Ana Osorio, Jeanette Valcich, Minerva Li, Therese Törngren, Patricia A. Harrington, Caroline Ba
Publié dans: New England Journal of Medicine, Numéro 384/5, 2021, Page(s) 428-439, ISSN 0028-4793
Éditeur: Massachusetts Medical Society
DOI: 10.1056/nejmoa1913948

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Auteurs: Iris Kramer, Maartje J. Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W. Steyerberg, Daniele Giardiello, Antonis C. Antoniou, Paul D.P. Pharoah, Sander Canisius, Zumuruda Abu-Ful, Irene L. Andrulis, Hoda Anton-Culver, Kristan J. Aronson, Annelie Augustinsson, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Natalia V. Bogdanova, Stig E. Boje
Publié dans: The American Journal of Human Genetics, Numéro 107/5, 2020, Page(s) 837-848, ISSN 0002-9297
Éditeur: University of Chicago Press
DOI: 10.1016/j.ajhg.2020.09.001

Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium

Auteurs: Myrto Barrdahl, Anja Rudolph, John L. Hopper, Melissa C. Southey, Annegien Broeks, Peter A. Fasching, Matthias W. Beckmann, Manuela Gago-Dominguez, J. Esteban Castelao, Pascal Guénel, Thérèse Truong, Stig E. Bojesen, Susan M. Gapstur, Mia M. Gaudet, Hermann Brenner, Volker Arndt, Hiltrud Brauch, Ute Hamann, Arto Mannermaa, Diether Lambrechts, Lynn Jongen, Dieter Flesch-Janys, Kathrin Thoene, Fe
Publié dans: International Journal of Cancer, Numéro 141/9, 2017, Page(s) 1830-1840, ISSN 0020-7136
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ijc.30859

Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium

Auteurs: Anja Rudolph, Minsun Song, Mark N Brook, Roger L Milne, Nasim Mavaddat, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Amber N Wilcox, John L Hopper, Melissa C Southey, Renske Keeman, Peter A Fasching, Matthias W Beckmann, Manuela Gago-Dominguez, Jose E Castelao, Pascal Guénel, Thérèse Truong, Stig E Bojesen, Henrik Flyger, Hermann Brenner, Volker Arndt, Hiltrud Brauch, Thomas Brü
Publié dans: International Journal of Epidemiology, Numéro 47/2, 2018, Page(s) 526-536, ISSN 0300-5771
Éditeur: Oxford University Press
DOI: 10.1093/ije/dyx242

A comprehensive tool for measuring mammographic density changes over time

Auteurs: Mikael Eriksson, Jingmei Li, Karin Leifland, Kamila Czene, Per Hall
Publié dans: Breast Cancer Research and Treatment, Numéro 169/2, 2018, Page(s) 371-379, ISSN 0167-6806
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10549-018-4690-5

Use of the BOADICEA Web Application in clinical practice: appraisals by clinicians from various countries

Auteurs: Anne Brédart, Jean-Luc Kop, Antonis C. Antoniou, Alex P. Cunningham, Antoine De Pauw, Marc Tischkowitz, Hans Ehrencrona, Sylvie Dolbeault, Léonore Robieux, Kerstin Rhiem, Douglas F. Easton, Peter Devilee, Dominique Stoppa-Lyonnet, Rita Schmutlzer
Publié dans: Familial Cancer, Numéro 17/1, 2018, Page(s) 31-41, ISSN 1389-9600
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10689-017-0014-x

A clinical model for identifying the short-term risk of breast cancer

Auteurs: Mikael Eriksson, Kamila Czene, Yudi Pawitan, Karin Leifland, Hatef Darabi, Per Hall
Publié dans: Breast Cancer Research, Numéro 19/1, 2017, ISSN 1465-542X
Éditeur: BMC
DOI: 10.1186/s13058-017-0820-y

Evaluating clinician acceptability of the prototype CanRisk tool for predicting risk of breast and ovarian cancer: A multi-methods study

Auteurs: Stephanie Archer, Chantal Babb de Villiers, Fiona Scheibl, Tim Carver, Simon Hartley, Andrew Lee, Alex P. Cunningham, Douglas F. Easton, Jennifer G. McIntosh, Jon Emery, Marc Tischkowitz, Antonis C. Antoniou, Fiona M. Walter
Publié dans: PLOS ONE, Numéro 15/3, 2020, Page(s) e0229999, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0229999

Transcriptome‐wide association study of breast cancer risk by estrogen‐receptor status

Auteurs: Helian Feng, Alexander Gusev, Bogdan Pasaniuc, Lang Wu, Jirong Long, Zomoroda Abu‐full, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Antonis C. Antoniou, Adalgeir Arason, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Ella Asseryanis, Paul L. Auer, Jacopo Azzollini, Judith Balmaña, Rosa B. Barkardottir, Daniel R. Barnes, Daniel Barrowdale, Matthias W. Beckmann, Sabine Behrens,
Publié dans: Genetic Epidemiology, 2020, ISSN 0741-0395
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/gepi.22288

Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium

Auteurs: Pooja Middha Kapoor, Sara Lindström, Sabine Behrens, Xiaoliang Wang, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Alison M Dunning, Paul D P Pharoah, Marjanka K Schmidt, Peter Kraft, Montserrat García-Closas, Douglas F Easton, Roger L Milne, Jenny Chang-Claude
Publié dans: International Journal of Epidemiology, Numéro 49/1, 2019, Page(s) 216-232, ISSN 0300-5771
Éditeur: Oxford University Press
DOI: 10.1093/ije/dyz193

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

Auteurs: Maria Escala-Garcia, Jean Abraham, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Alan Ashworth, Paul L. Auer, Päivi Auvinen, Matthias W. Beckmann, Jonathan Beesley, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, William Blot, Natalia V. Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Sara Y. Brucker, Barbara Burwin
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-14100-6

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Auteurs: Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R. Barnes, Jamie Allen, Siddhartha Kar, Karen A. Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemaçon, Michael Lush, Jonathan P. Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomäki, M. Rosario Alonso, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Adalge
Publié dans: Nature Genetics, Numéro 52/1, 2020, Page(s) 56-73, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/s41588-019-0537-1

Prediction and clinical utility of a contralateral breast cancer risk model

Auteurs: Daniele Giardiello, Ewout W. Steyerberg, Michael Hauptmann, Muriel A. Adank, Delal Akdeniz, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Mariël Brinkhuis, Jenny Chang-Claude, Kamila Czene, Peter Devilee, Alison M. Dunning, Douglas F. Easton, Diana M. Eccles, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Lothar Haeberle, Christopher A. Haiman, Per Hall, Ute Ha
Publié dans: Breast Cancer Research, Numéro 21/1, 2019, ISSN 1465-542X
Éditeur: BMC
DOI: 10.1186/s13058-019-1221-1

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Auteurs: Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna I. Kiiski, Taru A. Muranen, Daniel R. Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K. Bolla, Goska Leslie, Cora M. Aalfs, Muriel A. Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A. Agnarsson, Thomas Ahearn, Kristiina Aittomäki, Christine B. Ambrosone, Lesley Andrews, Hoda Anton
Publié dans: npj Breast Cancer, Numéro 5/1, 2019, ISSN 2374-4677
Éditeur: Nature Partner Journal Series
DOI: 10.1038/s41523-019-0127-5

Two truncating variants in FANCC and breast cancer risk

Auteurs: Thilo Dörk, Paolo Peterlongo, Arto Mannermaa, Manjeet K. Bolla, Qin Wang, Joe Dennis, Thomas Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Laura E. Beane Freeman, Matthias W. Beckmann, Alicia Beeghly-Fadiel, Sabine Behrens, Marina Bermisheva, Carl Blomqvist, Natalia V. Bogdanova, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Barbara Burw
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-48804-y

The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium

Auteurs: Tomotaka Ugai, Roger L. Milne, Hidemi Ito, Kristan J. Aronson, Manjeet K. Bolla, Tsun Chan, Ching W. Chan, Ji-Yeob Choi, Don M. Conroy, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Valerie Gaborieau, Anna Gonzalez-Neira, Mikael Hartman, Catherine S. Healey, Motoki Iwasaki, Esther M. John, Daehee Kang, Sung-Won Kim, Ava Kwong, Artitaya Lophatananon, Kyriaki Michailidou, Nur Aishah Mohd Taib, K
Publié dans: Molecular Genetics & Genomic Medicine, Numéro 7/6, 2019, Page(s) e707, ISSN 2324-9269
Éditeur: Wiley
DOI: 10.1002/mgg3.707

Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

Auteurs: Celine M. Vachon, Christopher G. Scott, Rulla M. Tamimi, Deborah J. Thompson, Peter A. Fasching, Jennifer Stone, Melissa C. Southey, Stacey Winham, Sara Lindström, Jenna Lilyquist, Graham G. Giles, Roger L. Milne, Robert J. MacInnis, Laura Baglietto, Jingmei Li, Kamila Czene, Manjeet K. Bolla, Qin Wang, Joe Dennis, Lothar Haeberle, Mikael Eriksson, Peter Kraft, Robert Luben, Nick Wareham, Janet E
Publié dans: Breast Cancer Research, Numéro 21/1, 2019, ISSN 1465-542X
Éditeur: BMC part of Springer Nature
DOI: 10.1186/s13058-019-1138-8

Genetically Predicted Levels of DNA Methylation Biomarkers and Breast Cancer Risk: Data From 228 951 Women of European Descent

Auteurs: Yaohua Yang, Lang Wu, Xiao-Ou Shu, Qiuyin Cai, Xiang Shu, Bingshan Li, Xingyi Guo, Fei Ye, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Irene L Andrulis, Hermann Brenner, Georgia Chenevix-Trench, Daniele Campa, Jose E Castelao, Manuela Gago-Dominguez, Thilo Dörk, Antoinette Hollestelle, Artitaya Lophatananon, Kenneth Muir, Susan L Neuhausen, Håkan Olsson, Dale P Sandler, Jacques S
Publié dans: JNCI: Journal of the National Cancer Institute, Numéro 112/3, 2019, Page(s) 295-304, ISSN 0027-8874
Éditeur: Oxford University Press
DOI: 10.1093/jnci/djz109

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Auteurs: Manuel A. Ferreira, Eric R. Gamazon, Fares Al-Ejeh, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton-Culver, Adalgeir Arason, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Ella Asseryanis, Jacopo Azzollini, Judith Balmaña, Daniel R. Barnes, Daniel Barrowdale, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Katarzyna Białkowska, Carl Blomqvist, Natalia V. Bogdanova,
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-08053-5

Genome-wide association study of germline variants and breast cancer-specific mortality

Auteurs: Maria Escala-Garcia, Qi Guo, Thilo Dörk, Sander Canisius, Renske Keeman, Joe Dennis, Jonathan Beesley, Julie Lecarpentier, Manjeet K. Bolla, Qin Wang, Jean Abraham, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Paul L. Auer, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Leslie Bernstein, Carl Blomqvist, Bram Boeckx, Stig E. Bojesen, Bernardo Bonanni, Anne-Lise Bø
Publié dans: British Journal of Cancer, Numéro 120/6, 2019, Page(s) 647-657, ISSN 0007-0920
Éditeur: Nature Publishing Group
DOI: 10.1038/s41416-019-0393-x

Shared heritability and functional enrichment across six solid cancers

Auteurs: Xia Jiang, Hilary K. Finucane, Fredrick R. Schumacher, Stephanie L. Schmit, Jonathan P. Tyrer, Younghun Han, Kyriaki Michailidou, Corina Lesseur, Karoline B. Kuchenbaecker, Joe Dennis, David V. Conti, Graham Casey, Mia M. Gaudet, Jeroen R. Huyghe, Demetrius Albanes, Melinda C. Aldrich, Angeline S. Andrew, Irene L. Andrulis, Hoda Anton-Culver, Antonis C. Antoniou, Natalia N. Antonenkova, Susanne M.
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-08054-4

BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors

Auteurs: Andrew Lee, Nasim Mavaddat, Amber N. Wilcox, Alex P. Cunningham, Tim Carver, Simon Hartley, Chantal Babb de Villiers, Angel Izquierdo, Jacques Simard, Marjanka K. Schmidt, Fiona M. Walter, Nilanjan Chatterjee, Montserrat Garcia-Closas, Marc Tischkowitz, Paul Pharoah, Douglas F. Easton, Antonis C. Antoniou
Publié dans: Genetics in Medicine, Numéro 21/8, 2019, Page(s) 1708-1718, ISSN 1098-3600
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41436-018-0406-9

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

Auteurs: Nasim Mavaddat, Kyriaki Michailidou, Joe Dennis, Michael Lush, Laura Fachal, Andrew Lee, Jonathan P. Tyrer, Ting-Huei Chen, Qin Wang, Manjeet K. Bolla, Xin Yang, Muriel A. Adank, Thomas Ahearn, Kristiina Aittomäki, Jamie Allen, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Päivi Auvinen, Myrto Barrdahl, Laura E. Beane Freeman, Matth
Publié dans: The American Journal of Human Genetics, Numéro 104/1, 2019, Page(s) 21-34, ISSN 0002-9297
Éditeur: University of Chicago Press
DOI: 10.1016/j.ajhg.2018.11.002

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

Auteurs: Lang Wu, Wei Shi, Jirong Long, Xingyi Guo, Kyriaki Michailidou, Jonathan Beesley, Manjeet K. Bolla, Xiao-Ou Shu, Yingchang Lu, Qiuyin Cai, Fares Al-Ejeh, Esdy Rozali, Qin Wang, Joe Dennis, Bingshan Li, Chenjie Zeng, Helian Feng, Alexander Gusev, Richard T. Barfield, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Myrto Barrdahl, Caroline Baynes, Matthias W. Be
Publié dans: Nature Genetics, Numéro 50/7, 2018, Page(s) 968-978, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/s41588-018-0132-x

E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium

Auteurs: Hisani N. Horne, Hannah Oh, Mark E. Sherman, Maya Palakal, Stephen M. Hewitt, Marjanka K. Schmidt, Roger L. Milne, David Hardisson, Javier Benitez, Carl Blomqvist, Manjeet K. Bolla, Hermann Brenner, Jenny Chang-Claude, Renata Cora, Fergus J. Couch, Katarina Cuk, Peter Devilee, Douglas F. Easton, Diana M. Eccles, Ursula Eilber, Jaana M. Hartikainen, Päivi Heikkilä, Bernd Holleczek, Maartje J. Hoo
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-23733-4

Clinicians’ use of breast cancer risk assessment tools according to their perceived importance of breast cancer risk factors: an international survey

Auteurs: Anne Brédart, Jean-Luc Kop, Antonis C. Antoniou, Alex P. Cunningham, Antoine De Pauw, Marc Tischkowitz, Hans Ehrencrona, Marjanka K. Schmidt, Sylvie Dolbeault, Kerstin Rhiem, Douglas F. Easton, Peter Devilee, Dominique Stoppa-Lyonnet, Rita Schmutlzer
Publié dans: Journal of Community Genetics, Numéro 10/1, 2019, Page(s) 61-71, ISSN 1868-310X
Éditeur: Springer Verlag
DOI: 10.1007/s12687-018-0362-8

Association analysis identifies 65 new breast cancer risk loci

Auteurs: Kyriaki Michailidou, Sara Lindström, Joe Dennis, Jonathan Beesley, Shirley Hui, Siddhartha Kar, Audrey Lemaçon, Penny Soucy, Dylan Glubb, Asha Rostamianfar, Manjeet K. Bolla, Qin Wang, Jonathan Tyrer, Ed Dicks, Andrew Lee, Zhaoming Wang, Jamie Allen, Renske Keeman, Ursula Eilber, Juliet D. French, Xiao Qing Chen, Laura Fachal, Karen McCue, Amy E. McCart Reed, Maya Ghoussaini, Jason S. Carroll, X
Publié dans: Nature, Numéro 551/7678, 2017, Page(s) 92-94, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/nature24284

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

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PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1

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Mammographic Density Change and Risk of Breast Cancer

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Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

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Personalised early detection and prevention of breast cancer: ENVISION Network Consensus Statement

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Genetic predisposition to mosaic Y chromosome loss in blood

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Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

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Breast Cancer Risk Factors and Survival by Tumor Subtype: Pooled Analyses from the Breast Cancer Association Consortium

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Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

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Prediction of contralateral breast cancer: external validation of risk calculators in 20 international cohorts

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A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

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Personalised prevention in breast cancer - the policy landscape

Auteurs: Sowmiya Moorthie, Louise Gaynor, Hilary Burton, Alison Hall, Mark Kroese, Sobia Raza
Publié dans: 2017, ISBN 978-1-907198-29-8
Éditeur: PHG Foundation, Cambridge

Personalising breast cancer prevention – bridging the gap between research and policy

Auteurs: Sowmiya Moorthie, Hilary Burton and Chantal Babb de Villiers
Publié dans: 2020
Éditeur: PHG Foundation Cambridge, UK

Personalising prevention for breast cancer - a workhop report

Auteurs: Sowmiya Moorthie, Hilary Burton, Louise Gaynor, Tanya Brigden, Chantal Babb de Villiers
Publié dans: 2019
Éditeur: PHG foundation Cambridge

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