An integrated approach to dissect determinants, risk factors and pathways of ageing of the immune system.

Project Information

ImmunoAgeing

Grant agreement ID: 633964

DOI 10.3030/633964

Project closed

EC signature date 7 April 2015

Start date 1 May 2015

End date 30 April 2019

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 5 850 000,00

EU contribution € 5 850 000,00

Coordinated by

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy

Deliverables

Websites, patent fillings, videos etc. (1)

Website development and management

The ImmunoAgeing website will be accessible on the internet at month 6 and it will be revised and improved during the whole course of the action Part of the website will be passwordprotected and dedicated to internal communication

Publications

Peer reviewed articles (4)

Overexpression of the Cytokine BAFF and Autoimmunity Risk

Author(s): Maristella Steri, Valeria Orrù, M. Laura Idda, Maristella Pitzalis, Mauro Pala, Ilenia Zara, Carlo Sidore, Valeria Faà, Matteo Floris, Manila Deiana, Isadora Asunis, Eleonora Porcu, Antonella Mulas, Maria G. Piras, Monia Lobina, Sandra Lai, Mara Marongiu, Valentina Serra, Michele Marongiu, Gabriella Sole, Fabio Busonero, Andrea Maschio, Roberto Cusano, Gianmauro Cuccuru, Francesca Deidda, Fausto
Published in: New England Journal of Medicine, Issue 376/17, 2017, Page(s) 1615-1626, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/NEJMoa1610528

Increased IL-15 Production and Accumulation of Highly Differentiated CD8+ Effector/Memory T Cells in the Bone Marrow of Persons with Cytomegalovirus

Author(s): Luca Pangrazzi, Erin Naismith, Andreas Meryk, Michael Keller, Brigitte Jenewein, Klemens Trieb, Beatrix Grubeck-Loebenstein
Published in: Frontiers in Immunology, Issue 8, 2017, Page(s) 715, ISSN 1664-3224
Publisher: Frontiers of Immunology
DOI: 10.3389/fimmu.2017.00715

CD8+HLADR+ Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function

Author(s): Stella Lukas Yani, Michael Keller, Franz Leonard Melzer, Birgit Weinberger, Luca Pangrazzi, Sieghart Sopper, Klemens Trieb, Monia Lobina, Valeria Orrù, Edoardo Fiorillo, Francesco Cucca, Beatrix Grubeck-Loebenstein
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.01201

Fcμ receptor as a Costimulatory Molecule for T Cells

Author(s): Andreas Meryk, Luca Pangrazzi, Magdalena Hagen, Florian Hatzmann, Brigitte Jenewein, Bojana Jakic, Natascha Hermann-Kleiter, Gottfried Baier, Juulia Jylhävä, Mikko Hurme, Klemens Trieb, Beatrix Grubeck-Loebenstein
Published in: Cell Reports, Issue 26/10, 2019, Page(s) 2681-2691.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.02.024