An integrated approach to dissect determinants, risk factors and pathways of ageing of the immune system.

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The ImmunoAgeing website will be accessible on the internet at month 6 and it will be revised and improved during the whole course of the action Part of the website will be passwordprotected and dedicated to internal communication

Publications

Overexpression of the Cytokine BAFF and Autoimmunity Risk

Auteurs: Maristella Steri, Valeria Orrù, M. Laura Idda, Maristella Pitzalis, Mauro Pala, Ilenia Zara, Carlo Sidore, Valeria Faà, Matteo Floris, Manila Deiana, Isadora Asunis, Eleonora Porcu, Antonella Mulas, Maria G. Piras, Monia Lobina, Sandra Lai, Mara Marongiu, Valentina Serra, Michele Marongiu, Gabriella Sole, Fabio Busonero, Andrea Maschio, Roberto Cusano, Gianmauro Cuccuru, Francesca Deidda, Fausto
Publié dans: New England Journal of Medicine, Numéro 376/17, 2017, Page(s) 1615-1626, ISSN 0028-4793
Éditeur: Massachusetts Medical Society
DOI: 10.1056/NEJMoa1610528

Increased IL-15 Production and Accumulation of Highly Differentiated CD8+ Effector/Memory T Cells in the Bone Marrow of Persons with Cytomegalovirus

Auteurs: Luca Pangrazzi, Erin Naismith, Andreas Meryk, Michael Keller, Brigitte Jenewein, Klemens Trieb, Beatrix Grubeck-Loebenstein
Publié dans: Frontiers in Immunology, Numéro 8, 2017, Page(s) 715, ISSN 1664-3224
Éditeur: Frontiers of Immunology
DOI: 10.3389/fimmu.2017.00715

CD8+HLADR+ Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function

Auteurs: Stella Lukas Yani, Michael Keller, Franz Leonard Melzer, Birgit Weinberger, Luca Pangrazzi, Sieghart Sopper, Klemens Trieb, Monia Lobina, Valeria Orrù, Edoardo Fiorillo, Francesco Cucca, Beatrix Grubeck-Loebenstein
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.01201

Fcμ receptor as a Costimulatory Molecule for T Cells

Auteurs: Andreas Meryk, Luca Pangrazzi, Magdalena Hagen, Florian Hatzmann, Brigitte Jenewein, Bojana Jakic, Natascha Hermann-Kleiter, Gottfried Baier, Juulia Jylhävä, Mikko Hurme, Klemens Trieb, Beatrix Grubeck-Loebenstein
Publié dans: Cell Reports, Numéro 26/10, 2019, Page(s) 2681-2691.e5, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2019.02.024

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