An integrated approach to dissect determinants, risk factors and pathways of ageing of the immune system.

Informazioni relative al progetto

ImmunoAgeing

ID dell’accordo di sovvenzione: 633964

DOI 10.3030/633964

Progetto chiuso

Data della firma CE 7 Aprile 2015

Data di avvio 1 Maggio 2015

Data di completamento 30 Aprile 2019

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale € 5 850 000,00

Contributo UE € 5 850 000,00

Coordinato da

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy

Risultati finali

Websites, patent fillings, videos etc. (1)

Website development and management

The ImmunoAgeing website will be accessible on the internet at month 6 and it will be revised and improved during the whole course of the action Part of the website will be passwordprotected and dedicated to internal communication

Pubblicazioni

Peer reviewed articles (4)

Overexpression of the Cytokine BAFF and Autoimmunity Risk

Autori: Maristella Steri, Valeria Orrù, M. Laura Idda, Maristella Pitzalis, Mauro Pala, Ilenia Zara, Carlo Sidore, Valeria Faà, Matteo Floris, Manila Deiana, Isadora Asunis, Eleonora Porcu, Antonella Mulas, Maria G. Piras, Monia Lobina, Sandra Lai, Mara Marongiu, Valentina Serra, Michele Marongiu, Gabriella Sole, Fabio Busonero, Andrea Maschio, Roberto Cusano, Gianmauro Cuccuru, Francesca Deidda, Fausto
Pubblicato in: New England Journal of Medicine, Numero 376/17, 2017, Pagina/e 1615-1626, ISSN 0028-4793
Editore: Massachusetts Medical Society
DOI: 10.1056/NEJMoa1610528

Increased IL-15 Production and Accumulation of Highly Differentiated CD8+ Effector/Memory T Cells in the Bone Marrow of Persons with Cytomegalovirus

Autori: Luca Pangrazzi, Erin Naismith, Andreas Meryk, Michael Keller, Brigitte Jenewein, Klemens Trieb, Beatrix Grubeck-Loebenstein
Pubblicato in: Frontiers in Immunology, Numero 8, 2017, Pagina/e 715, ISSN 1664-3224
Editore: Frontiers of Immunology
DOI: 10.3389/fimmu.2017.00715

CD8+HLADR+ Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function

Autori: Stella Lukas Yani, Michael Keller, Franz Leonard Melzer, Birgit Weinberger, Luca Pangrazzi, Sieghart Sopper, Klemens Trieb, Monia Lobina, Valeria Orrù, Edoardo Fiorillo, Francesco Cucca, Beatrix Grubeck-Loebenstein
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.01201

Fcμ receptor as a Costimulatory Molecule for T Cells

Autori: Andreas Meryk, Luca Pangrazzi, Magdalena Hagen, Florian Hatzmann, Brigitte Jenewein, Bojana Jakic, Natascha Hermann-Kleiter, Gottfried Baier, Juulia Jylhävä, Mikko Hurme, Klemens Trieb, Beatrix Grubeck-Loebenstein
Pubblicato in: Cell Reports, Numero 26/10, 2019, Pagina/e 2681-2691.e5, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.02.024