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Novel biocontrol agents for insect pests from neuroendocrinology

Objectif

Insects are the most diverse Class of life on earth, and different insects can be essential for, or highly damaging to, agriculture, horticulture and forestry. There is a pressing need, not just for new insecticides to combat resistance, but more specific, “greener” insecticides that target deleterious insects while sparing beneficial ones. This proposal aims to identify such insecticides by turning the insects’ own hormones against them, both by designing artificial neuropeptide “mimetic” analogs as candidate compounds, and by generating transgenic insects that carry deleterious neuropeptide payloads within them, that can propagate through a population and impact on survival at times of stress.

We have assembled an international multi-actor consortium from EU member and associated member states, as well as a third country partner, with unparalleled experience in insect functional genomics, neuropeptide physiology, synthetic chemistry and synthetic biology, and in field-testing of candidates. Established links to agricultural, horticultural and forestry end-users, agencies/advisors and our SME partners ensure relevance to user need; and set out a pathway to exploitation and implementation of our results, for impact across three major economic sectors in the EU and globally.

We will deliver novel, ‘green’ neuropeptide-based insect pest biocontrol tools by:
• utilising ‘beyond the State-of-the-Art’ technologies based on two approaches: rational design of neuropeptide hormone analogues; and development of genetically-encoded neuropeptides for translational insect synthetic biology in genetic pest management.
• bridging outstanding research and technology in neuroendocrinology and genetics to end user need, to ultimately produce neuropeptide hormone analogues and genetic pest management biocontrol tools.
• validating and demonstrating these novel insect biocontrol agents in laboratory, field and forest applications, based on user need and a market-driven approach.

Appel à propositions

H2020-SFS-2014-2015

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Sous appel

H2020-SFS-2014-2

Coordinateur

UNIVERSITY OF GLASGOW
Contribution nette de l'UE
€ 2 318 875,00
Adresse
University Avenue
G12 8QQ Glasgow
United Kingdom

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Région
West Central Scotland Glasgow City
Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,00

Participants (13)

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgique
Contribution nette de l'UE
€ 530 000,00
Adresse
Oude Markt 13
3000 Leuven

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Région
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,00
UNIVERSITEIT GENT
Belgique
Contribution nette de l'UE
€ 511 625,00
Adresse
Sint Pietersnieuwstraat 25
9000 Gent

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Région
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,00
THE AGRICULTURAL RESEARCH ORGANISATION OF ISRAEL - THE VOLCANI CENTRE
Israël
Contribution nette de l'UE
€ 679 687,50
Adresse
Derech Hamcabim 68
50250 Bet Dagan

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Type d’activité
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contribution hors UE
€ 0,00
STOCKHOLMS UNIVERSITET
Suède
Contribution nette de l'UE
€ 378 406,00
Adresse
Universitetsvagen 10
10691 Stockholm

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Région
Östra Sverige Stockholm Stockholms län
Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,25
UNIVERSITAT ZU KOLN
Allemagne
Contribution nette de l'UE
€ 442 500,00
Adresse
Albertus Magnus Platz
50931 Koln

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Région
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,00
UNIVERSITY OF LEEDS
United Kingdom
Contribution nette de l'UE
€ 341 278,50
Adresse
Woodhouse Lane
LS2 9JT Leeds

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Région
Yorkshire and the Humber West Yorkshire Leeds
Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,25
SCOTTISH GOVERNMENT
United Kingdom
Contribution nette de l'UE
€ 62 031,00
Adresse
St Andrews House, Regent Road
EH1 3DG Edinburgh

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Région
Eastern Scotland Edinburgh
Type d’activité
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contribution hors UE
€ 0,25
FORESTRY COMMISSION RESEARCH AGENCY
United Kingdom
Contribution nette de l'UE
€ 176 481,00
Adresse
Alice Holt Lodge
GU10 4LH Farnham

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Région
South East (England) Hampshire and Isle of Wight Central Hampshire
Type d’activité
Research Organisations
Contribution hors UE
€ 0,25
UNIVERSITY OF CAPE TOWN
Afrique du Sud
Contribution nette de l'UE
€ 62 500,00
Adresse
Private Bag X3
7701 Rondebosch

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Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,00
Bruker Daltonik GmbH
Allemagne
Contribution nette de l'UE
€ 438 375,00
Adresse
Fahrenheitsstr.
28359 Bremen

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contribution hors UE
€ 0,00
THE PIRBRIGHT INSTITUTE LBG
United Kingdom
Contribution nette de l'UE
€ 719 860,00
Adresse
Ash Road Pirbright
GU24 0NF Woking

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Région
South East (England) Surrey, East and West Sussex West Surrey
Type d’activité
Research Organisations
Contribution hors UE
€ 0,00
Oxitec Limited
United Kingdom
Contribution nette de l'UE
€ 245 933,50
Adresse
Miton Park 71
OX14 4RX Oxford

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PME

L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.

Oui
Région
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contribution hors UE
€ 0,25
KNOWLEDGE TRANSFER NETWORK LIMITED
United Kingdom
Contribution nette de l'UE
€ 87 500,00
Adresse
52 Upper Street Suite 218 Business Design Centre Islington
N1 0QH London

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PME

L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.

Oui
Région
London Inner London — East Haringey and Islington
Type d’activité
Other
Contribution hors UE
€ 0,00