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Novel biocontrol agents for insect pests from neuroendocrinology

Obiettivo

Insects are the most diverse Class of life on earth, and different insects can be essential for, or highly damaging to, agriculture, horticulture and forestry. There is a pressing need, not just for new insecticides to combat resistance, but more specific, “greener” insecticides that target deleterious insects while sparing beneficial ones. This proposal aims to identify such insecticides by turning the insects’ own hormones against them, both by designing artificial neuropeptide “mimetic” analogs as candidate compounds, and by generating transgenic insects that carry deleterious neuropeptide payloads within them, that can propagate through a population and impact on survival at times of stress.

We have assembled an international multi-actor consortium from EU member and associated member states, as well as a third country partner, with unparalleled experience in insect functional genomics, neuropeptide physiology, synthetic chemistry and synthetic biology, and in field-testing of candidates. Established links to agricultural, horticultural and forestry end-users, agencies/advisors and our SME partners ensure relevance to user need; and set out a pathway to exploitation and implementation of our results, for impact across three major economic sectors in the EU and globally.

We will deliver novel, ‘green’ neuropeptide-based insect pest biocontrol tools by:
• utilising ‘beyond the State-of-the-Art’ technologies based on two approaches: rational design of neuropeptide hormone analogues; and development of genetically-encoded neuropeptides for translational insect synthetic biology in genetic pest management.
• bridging outstanding research and technology in neuroendocrinology and genetics to end user need, to ultimately produce neuropeptide hormone analogues and genetic pest management biocontrol tools.
• validating and demonstrating these novel insect biocontrol agents in laboratory, field and forest applications, based on user need and a market-driven approach.

Invito a presentare proposte

H2020-SFS-2014-2015

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Bando secondario

H2020-SFS-2014-2

Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

UNIVERSITY OF GLASGOW
Contribution nette de l'UE
€ 2 318 875,00
Indirizzo
University Avenue
G12 8QQ Glasgow
United Kingdom

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Regione
West Central Scotland Glasgow City
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00

Partecipanti (13)

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgio
Contribution nette de l'UE
€ 530 000,00
Indirizzo
Oude Markt 13
3000 Leuven

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Regione
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00
UNIVERSITEIT GENT
Belgio
Contribution nette de l'UE
€ 511 625,00
Indirizzo
Sint Pietersnieuwstraat 25
9000 Gent

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Regione
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00
THE AGRICULTURAL RESEARCH ORGANISATION OF ISRAEL - THE VOLCANI CENTRE
Israele
Contribution nette de l'UE
€ 679 687,50
Indirizzo
Derech Hamcabim 68
50250 Bet Dagan

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Tipo di attività
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contributo di paesi terzi
€ 0,00
STOCKHOLMS UNIVERSITET
Svezia
Contribution nette de l'UE
€ 378 406,00
Indirizzo
Universitetsvagen 10
10691 Stockholm

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Regione
Östra Sverige Stockholm Stockholms län
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,25
UNIVERSITAT ZU KOLN
Germania
Contribution nette de l'UE
€ 442 500,00
Indirizzo
Albertus Magnus Platz
50931 Koln

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Regione
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00
UNIVERSITY OF LEEDS
United Kingdom
Contribution nette de l'UE
€ 341 278,50
Indirizzo
Woodhouse Lane
LS2 9JT Leeds

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Regione
Yorkshire and the Humber West Yorkshire Leeds
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,25
SCOTTISH GOVERNMENT
United Kingdom
Contribution nette de l'UE
€ 62 031,00
Indirizzo
St Andrews House, Regent Road
EH1 3DG Edinburgh

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Regione
Eastern Scotland Edinburgh
Tipo di attività
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contributo di paesi terzi
€ 0,25
FORESTRY COMMISSION RESEARCH AGENCY
United Kingdom
Contribution nette de l'UE
€ 176 481,00
Indirizzo
Alice Holt Lodge
GU10 4LH Farnham

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Regione
South East (England) Hampshire and Isle of Wight Central Hampshire
Tipo di attività
Research Organisations
Contributo di paesi terzi
€ 0,25
UNIVERSITY OF CAPE TOWN
Sud Africa
Contribution nette de l'UE
€ 62 500,00
Indirizzo
Private Bag X3
7701 Rondebosch

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Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00
Bruker Daltonik GmbH
Germania
Contribution nette de l'UE
€ 438 375,00
Indirizzo
Fahrenheitsstr.
28359 Bremen

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contributo di paesi terzi
€ 0,00
THE PIRBRIGHT INSTITUTE LBG
United Kingdom
Contribution nette de l'UE
€ 719 860,00
Indirizzo
Ash Road Pirbright
GU24 0NF Woking

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Regione
South East (England) Surrey, East and West Sussex West Surrey
Tipo di attività
Research Organisations
Contributo di paesi terzi
€ 0,00
Oxitec Limited
United Kingdom
Contribution nette de l'UE
€ 245 933,50
Indirizzo
Miton Park 71
OX14 4RX Oxford

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PMI

L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione.

Regione
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contributo di paesi terzi
€ 0,25
KNOWLEDGE TRANSFER NETWORK LIMITED
United Kingdom
Contribution nette de l'UE
€ 87 500,00
Indirizzo
52 Upper Street Suite 218 Business Design Centre Islington
N1 0QH London

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PMI

L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione.

Regione
London Inner London — East Haringey and Islington
Tipo di attività
Other
Contributo di paesi terzi
€ 0,00