Elucidating Pathways of Steatohepatitis

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Detailed dissemination plan
Final reports summarising recruitment into the EPoS database, biobanked samples availability, and longitudinal outcome studies
Report on data management plan for the EPoS project
Project Handbook
Risk assessment procedure

Publicaciones

Relationship Among Fatty Liver, Specific and Multiple‐Site Atherosclerosis, and 10‐Year Framingham Score

Autores: Raluca Pais, Alban Redheuil, Philippe Cluzel, Vlad Ratziu, Philippe Giral
Publicado en: Hepatology, Edición 69/4, 2019, Página(s) 1453-1463, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.30223

Autores: Yvonne Huber, Marie Boyle, Kate Hallsworth, Dina Tiniakos, Beate K. Straub, Christian Labenz, Christian Ruckes, Peter R. Galle, Manuel Romero-Gómez, Quentin M. Anstee, Jörn M. Schattenberg
Publicado en: Clinical Gastroenterology and Hepatology, Edición 17/10, 2019, Página(s) 2085-2092.e1, ISSN 1542-3565
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cgh.2018.12.016

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

Autores: Judith Aron-Wisnewsky, Chloé Vigliotti, Julia Witjes, Phuong Le, Adriaan G. Holleboom, Joanne Verheij, Max Nieuwdorp, Karine Clément
Publicado en: Nature Reviews Gastroenterology & Hepatology, Edición 17/5, 2020, Página(s) 279-297, ISSN 1759-5045
Editor: Nature Publishing Group
DOI: 10.1038/s41575-020-0269-9

Usefulness of the index of NASH - ION for the diagnosis of steatohepatitis in patients with non-alcoholic fatty liver: An external validation study

Autores: Ramy Younes, Chiara Rosso, Salvatore Petta, Monica Cucco, Milena Marietti, Gian Paolo Caviglia, Alessia Ciancio, Maria Lorena Abate, Carlo Cammà, Antonina Smedile, Antonio Craxì, Giorgio Maria Saracco, Elisabetta Bugianesi
Publicado en: Liver International, Edición 38/4, 2018, Página(s) 715-723, ISSN 1478-3223
Editor: Blackwell Publishing Inc.
DOI: 10.1111/liv.13612

Predictors of advanced fibrosis in non-cirrhotic non-alcoholic fatty liver disease in Germany

Autores: Christian Labenz, Yvonne Huber, Eva Kalliga, Michael Nagel, Christian Ruckes, Beate K. Straub, Peter R. Galle, Marcus-Alexander Wörns, Quentin M. Anstee, Detlef Schuppan, Jörn M. Schattenberg
Publicado en: Alimentary Pharmacology & Therapeutics, Edición 48/10, 2018, Página(s) 1109-1116, ISSN 0269-2813
Editor: Blackwell Publishing Inc.
DOI: 10.1111/apt.14976

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆

Autores: Quentin M. Anstee, Rebecca Darlay, Simon Cockell, Marica Meroni, Olivier Govaere, Dina Tiniakos, Alastair D. Burt, Pierre Bedossa, Jeremy Palmer, Yang-Lin Liu, Guruprasad P. Aithal, Michael Allison, Hannele Yki-Järvinen, Michele Vacca, Jean-Francois Dufour, Pietro Invernizzi, Daniele Prati, Mattias Ekstedt, Stergios Kechagias, Sven Francque, Salvatore Petta, Elisabetta Bugianesi, Karine Clement,
Publicado en: Journal of Hepatology, Edición 73/3, 2020, Página(s) 505-515, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2020.04.003

Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma

Autores: Zoe Hall, Davide Chiarugi, Evelina Charidemou, Jack Leslie, Emma Scott, Luca Pellegrinet, Michael Allison, Gabriele Mocciaro, Quentin M. Anstee, Gerard I. Evan, Matthew Hoare, Antonio Vidal‐Puig, Fiona Oakley, Michele Vacca, Julian L. Griffin
Publicado en: Hepatology, Edición 73/3, 2021, Página(s) 1028-1044, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.31391

Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?

Autores: Ramy Younes, Olivier Govaere, Salvatore Petta, Luca Miele, Dina Tiniakos, Alastair Burt, Ezio David, Fabio Maria Vecchio, Marco Maggioni, Daniela Cabibi, Duncan McLeod, Maria Jesus Pareja, Anna Ludovica Fracanzani, Rocio Aller, Chiara Rosso, Javier Ampuero, Rocío Gallego-Durán, Angelo Armandi, Gian Paolo Caviglia, Marco Y W Zaki, Antonio Liguori, Paolo Francione, Grazia Pennisi, Antonio Grieco,
Publicado en: Gut, 2021, Página(s) gutjnl-2020-322564, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-322564

Clinical implications of hepatic progenitor cell activation in non-alcoholic fatty liver disease

Autores: Ramy Younes, Rachel Burgoyne, Dina Tiniakos, Olivier Govaere
Publicado en: Hepatoma Research, Edición 2021, 2021, ISSN 2454-2520
Editor: -
DOI: 10.20517/2394-5079.2020.119

Quantitative PCR provides a simple and accessible method for quantitative microbiota profiling

Autores: Ching Jian, Panu Luukkonen, Hannele Yki-Järvinen, Anne Salonen, Katri Korpela
Publicado en: PLOS ONE, Edición 15/1, 2020, Página(s) e0227285, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0227285

Elevated serum ceramides are linked with obesity-associated gut dysbiosis and impaired glucose metabolism

Autores: Brandon D. Kayser, Edi Prifti, Marie Lhomme, Eugeni Belda, Maria-Carlota Dao, Judith Aron-Wisnewsky, Anatol Kontush, Jean-Daniel Zucker, Salwa W. Rizkalla, Isabelle Dugail, Karine Clément
Publicado en: Metabolomics, Edición 15/11, 2019, ISSN 1573-3882
Editor: Springer Verlag
DOI: 10.1007/s11306-019-1596-0

Interplay between metabolic derangement, hepatic fibrogenesis and macrophage activation in non-diabetic patients with non-alcoholic fatty liver disease

Autores: C. Rosso, R. Younes, D.J. Leeming, R. Surabattula, G.P. Caviglia, M. Gaggini, A. Armandi, A. Olivero, M.L. Abate, A. Gastaldelli, D. Schuppan, E. Bugianesi
Publicado en: Digestive and Liver Disease, Edición 52, 2020, Página(s) e10, ISSN 1590-8658
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.dld.2019.12.025

Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease

Autores: Tuulia Hyötyläinen, Livnat Jerby, Elina M. Petäjä, Ismo Mattila, Sirkku Jäntti, Petri Auvinen, Amalia Gastaldelli, Hannele Yki-Järvinen, Eytan Ruppin, Matej Orešič
Publicado en: Nature Communications, Edición 7, 2016, Página(s) 8994, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms9994

Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance

Autores: Hannele Yki-Järvinen
Publicado en: Nutrients, Edición 7/11, 2015, Página(s) 9127-9138, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu7115454

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Autores: Zobair Younossi, Quentin M. Anstee, Milena Marietti, Timothy Hardy, Linda Henry, Mohammed Eslam, Jacob George, Elisabetta Bugianesi
Publicado en: Nature Reviews Gastroenterology & Hepatology, Edición 15/1, 2017, Página(s) 11-20, ISSN 1759-5045
Editor: Nature Publishing Group
DOI: 10.1038/nrgastro.2017.109

Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD

Autores: Elina M. Petäjä, You Zhou, Marika Havana, Antti Hakkarainen, Nina Lundbom, Jarkko Ihalainen, Hannele Yki-Järvinen
Publicado en: Scientific Reports, Edición 6/1, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep24740

Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy

Autores: Morten A. Karsdal, Kim Henriksen, Mette Juul Nielsen, Inger Byrjalsen, Diana J. Leeming, Stephen Gardner, Zachary Goodman, Keyur Patel, Aleksander Krag, Claus Christiansen, Detlef Schuppan
Publicado en: American Journal of Physiology-Gastrointestinal and Liver Physiology, Edición 311/6, 2016, Página(s) G1009-G1017, ISSN 0193-1857
Editor: American Physiological Society
DOI: 10.1152/ajpgi.00283.2016

MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals

Autores: Benedetta Donati, Paola Dongiovanni, Stefano Romeo, Marica Meroni, Misti McCain, Luca Miele, Salvatore Petta, Silvia Maier, Chiara Rosso, Laura De Luca, Ester Vanni, Stefania Grimaudo, Renato Romagnoli, Fabio Colli, Flaminia Ferri, Rosellina Margherita Mancina, Paula Iruzubieta, Antonio Craxi, Anna Ludovica Fracanzani, Antonio Grieco, Stefano Ginanni Corradini, Alessio Aghemo, Massimo Colombo, Gio
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-04991-0

NAFLD: PNPLA3 and obesity: a synergistic relationship in NAFLD

Autores: Jake P. Mann, Quentin M. Anstee
Publicado en: Nature Reviews Gastroenterology & Hepatology, Edición 14/9, 2017, Página(s) 506-507, ISSN 1759-5045
Editor: Nature Publishing Group
DOI: 10.1038/nrgastro.2017.74

Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis

Autores: Stuart McPherson, Tim Hardy, Jean-Francois Dufour, Salvatore Petta, Manuel Romero-Gomez, Mike Allison, Claudia P Oliveira, Sven Francque, Luc Van Gaal, Jörn M Schattenberg, Dina Tiniakos, Alastair Burt, Elisabetta Bugianesi, Vlad Ratziu, Christopher P Day, Quentin M Anstee
Publicado en: The American Journal of Gastroenterology, Edición 112/5, 2016, Página(s) 740-751, ISSN 0002-9270
Editor: Blackwell Publishing Inc.
DOI: 10.1038/ajg.2016.453

Serum lipidomics reveals early differential effects of gastric bypass compared with banding on phospholipids and sphingolipids independent of differences in weight loss

Autores: B D Kayser, M Lhomme, M C Dao, F Ichou, J-L Bouillot, E Prifti, A Kontush, J-M Chevallier, J Aron-Wisnewsky, I Dugail, K Clément
Publicado en: International Journal of Obesity, Edición 41/6, 2017, Página(s) 917-925, ISSN 0307-0565
Editor: Nature Publishing Group
DOI: 10.1038/ijo.2017.63

Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLD—A Systematic Review

Autores: Elina Petäjä, Hannele Yki-Järvinen
Publicado en: International Journal of Molecular Sciences, Edición 17/5, 2016, Página(s) 633, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms17050633

Glucose kinetics

Autores: Amalia Gastaldelli, Melania Gaggini, Ralph DeFronzo
Publicado en: Current Opinion in Clinical Nutrition and Metabolic Care, Edición 20/4, 2017, Página(s) 300-309, ISSN 1363-1950
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MCO.0000000000000384

The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans

Autores: Panu K. Luukkonen, You Zhou, Tuulia Hyötyläinen, Marja Leivonen, Johanna Arola, Marju Orho-Melander, Matej Orešič, Hannele Yki-Järvinen
Publicado en: Journal of Hepatology, Edición 65/6, 2016, Página(s) 1263-1265, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2016.07.045

Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans

Autores: Panu K. Luukkonen, You Zhou, Elina Isokuortti, Marja Leivonen, Anne Juuti, Antti Hakkarainen, Marju Orho-Melander, Nina Lundbom, Vesa M. Olkkonen, Riitta Lassila, Hannele Yki-Järvinen, Susanna Lallukka
Publicado en: Thrombosis and Haemostasis, Edición 117/02, 2017, Página(s) 286-294, ISSN 0340-6245
Editor: Schattauer
DOI: 10.1160/TH16-09-0716

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

Autores: Leon A Adams, Quentin M Anstee, Herbert Tilg, Giovanni Targher
Publicado en: Gut, Edición 66/6, 2017, Página(s) 1138-1153, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2017-313884

Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease

Autores: Zoe Hall, Nicholas J. Bond, Tom Ashmore, Francis Sanders, Zsuzsanna Ament, Xinzhu Wang, Andrew J. Murray, Elena Bellafante, Sam Virtue, Antonio Vidal-Puig, Michael Allison, Susan E. Davies, Albert Koulman, Michele Vacca, Julian L. Griffin
Publicado en: Hepatology, Edición 65/4, 2017, Página(s) 1165-1180, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.28953

Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study

Autores: Elina Isokuortti, You Zhou, Markku Peltonen, Elisabetta Bugianesi, Karine Clement, Dominique Bonnefont-Rousselot, Jean-Marc Lacorte, Amalia Gastaldelli, Detlef Schuppan, Jörn M. Schattenberg, Antti Hakkarainen, Nina Lundbom, Pekka Jousilahti, Satu Männistö, Sirkka Keinänen-Kiukaanniemi, Juha Saltevo, Quentin M. Anstee, Hannele Yki-Järvinen
Publicado en: Diabetologia, Edición 60/10, 2017, Página(s) 1873-1882, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-017-4340-1

Role of Adipose Tissue Insulin Resistance in the Natural History of Type 2 Diabetes: Results From the San Antonio Metabolism Study

Autores: Amalia Gastaldelli, Melania Gaggini, Ralph A. DeFronzo
Publicado en: Diabetes, Edición 66/4, 2017, Página(s) 815-822, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db16-1167

Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD

Autores: Panu K. Luukkonen, You Zhou, P.A. Nidhina Haridas, Om P. Dwivedi, Tuulia Hyötyläinen, Ashfaq Ali, Anne Juuti, Marja Leivonen, Taru Tukiainen, Linda Ahonen, Emma Scott, Jeremy M. Palmer, Johanna Arola, Marju Orho-Melander, Petter Vikman, Quentin M. Anstee, Vesa M. Olkkonen, Matej Orešič, Leif Groop, Hannele Yki-Järvinen
Publicado en: Journal of Hepatology, Edición 67/1, 2017, Página(s) 128-136, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2017.02.014

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

Autores: Shabnam Shalapour, Xue-Jia Lin, Ingmar N. Bastian, John Brain, Alastair D. Burt, Alexander A. Aksenov, Alison F. Vrbanac, Weihua Li, Andres Perkins, Takaji Matsutani, Zhenyu Zhong, Debanjan Dhar, Jose A. Navas-Molina, Jun Xu, Rohit Loomba, Michael Downes, Ruth T. Yu, Ronald M. Evans, Pieter C. Dorrestein, Rob Knight, Christopher Benner, Quentin M. Anstee, Michael Karin
Publicado en: Nature, Edición 551/7680, 2017, Página(s) 340-345, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature24302

Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance

Autores: Melania Gaggini, Fabrizia Carli, Chiara Rosso, Emma Buzzigoli, Milena Marietti, Veronica Della Latta, Demetrio Ciociaro, Maria Lorena Abate, Roberto Gambino, Maurizio Cassader, Elisabetta Bugianesi, Amalia Gastaldelli
Publicado en: Hepatology, Edición 67/1, 2018, Página(s) 145-158, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.29465

The good and the bad collagens of fibrosis – Their role in signaling and organ function

Autores: M.A. Karsdal, S.H. Nielsen, D.J. Leeming, L.L. Langholm, M.J. Nielsen, T. Manon-Jensen, A. Siebuhr, N.S. Gudmann, S. Rønnow, J.M. Sand, S.J. Daniels, J.H. Mortensen, D. Schuppan
Publicado en: Advanced Drug Delivery Reviews, Edición 121, 2017, Página(s) 43-56, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2017.07.014

Should we undertake surveillance for HCC in patients with NAFLD?

Autores: Ramy Younes, Elisabetta Bugianesi
Publicado en: Journal of Hepatology, Edición 68/2, 2018, Página(s) 326-334, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2017.10.006

The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease

Autores: Marie Boyle, Steven Masson, Quentin M. Anstee
Publicado en: Journal of Hepatology, Edición 68/2, 2018, Página(s) 251-267, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2017.11.006

Hypoxia-inducible factor 2α drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine-rich glycoprotein

Autores: Elisabetta Morello, Salvatore Sutti, Beatrice Foglia, Erica Novo, Stefania Cannito, Claudia Bocca, Martina Rajsky, Stefania Bruzzì, Maria Lorena Abate, Chiara Rosso, Cristina Bozzola, Ezio David, Elisabetta Bugianesi, Emanuele Albano, Maurizio Parola
Publicado en: Hepatology, Edición 67/6, 2018, Página(s) 2196-2214, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.29754

Determinants of fibrosis progression and regression in NASH

Autores: Detlef Schuppan, Rambabu Surabattula, Xiao Yu Wang
Publicado en: Journal of Hepatology, Edición 68/2, 2018, Página(s) 238-250, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2017.11.012

Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study

Autores: Susanna Lallukka, Sanja Sädevirta, Markus T. Kallio, Panu K. Luukkonen, You Zhou, Antti Hakkarainen, Nina Lundbom, Marju Orho-Melander, Hannele Yki-Järvinen
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-14706-0

Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD

Autores: Michael Allison, Julian Griffin, Michele Vacca, Antonio Vidal-Puig
Publicado en: Seminars in Liver Disease, Edición 35/03, 2015, Página(s) 250-261, ISSN 0272-8087
Editor: Thieme Medical Publishers
DOI: 10.1055/s-0035-1562945

Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease

Autores: Quentin M. Anstee, Devanshi Seth, Christopher P. Day
Publicado en: Gastroenterology, Edición 150/8, 2016, Página(s) 1728-1744.e7, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.01.037

Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease

Autores: Timothy Hardy, Mujdat Zeybel, Christopher P Day, Christian Dipper, Steven Masson, Stuart McPherson, Elsbeth Henderson, Dina Tiniakos, Steve White, Jeremy French, Derek A Mann, Quentin M Anstee, Jelena Mann
Publicado en: Gut, Edición 0, 1-8, 2016, Página(s) gutjnl-2016-311526, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-311526

Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis

Autores: M. Noureddin, Q. M. Anstee, R. Loomba
Publicado en: Alimentary Pharmacology & Therapeutics, Edición 43/11, 2016, Página(s) 1109-1123, ISSN 0269-2813
Editor: Blackwell Publishing Inc.
DOI: 10.1111/apt.13620

The Genetics of Nonalcoholic Fatty Liver Disease: Spotlight on PNPLA3 and TM6SF2

Autores: Christopher Day, Quentin Anstee
Publicado en: Seminars in Liver Disease, Edición 35/03, 2015, Página(s) 270-290, ISSN 0272-8087
Editor: Thieme Medical Publishers
DOI: 10.1055/s-0035-1562947

Serum endotrophin identifies optimal responders to PPARγ agonists in type 2 diabetes

Autores: Morten A. Karsdal, Kim Henriksen, Federica Genovese, Diana J. Leeming, Mette J. Nielsen, Bente J. Riis, Claus Christiansen, Inger Byrjalsen, Detlef Schuppan
Publicado en: Diabetologia, Edición 60/1, 2017, Página(s) 50-59, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-016-4094-1

Genetics of Alcoholic Liver Disease

Autores: Ann Daly, Christopher Day, Quentin Anstee
Publicado en: Seminars in Liver Disease, Edición 35/04, 2015, Página(s) 361-374, ISSN 0272-8087
Editor: Thieme Medical Publishers
DOI: 10.1055/s-0035-1567832

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

Autores: Timothy Hardy, Fiona Oakley, Quentin M. Anstee, Christopher P. Day
Publicado en: Annual Review of Pathology: Mechanisms of Disease, Edición 11/1, 2016, Página(s) 451-496, ISSN 1553-4006
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-pathol-012615-044224

Peripheral insulin resistance predicts liver damage in nondiabetic subjects with nonalcoholic fatty liver disease

Autores: Chiara Rosso, Lavinia Mezzabotta, Melania Gaggini, Federico Salomone, Roberto Gambino, Andrea Marengo, Francesca Saba, Ester Vanni, Rami I.K. Jouness, Chiara Saponaro, Emma Buzzigoli, Gian Paolo Caviglia, Maria Lorena Abate, Antonina Smedile, Mario Rizzetto, Maurizio Cassader, Amalia Gastaldelli, Elisabetta Bugianesi
Publicado en: Hepatology, Edición 63/1, 2016, Página(s) 107-116, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.28287

Systematic review of bariatric surgery liver biopsies clarifies the natural history of liver disease in patients with severe obesity

Autores: Pierre Bedossa, Joan Tordjman, Judith Aron-Wisnewsky, Christine Poitou, Jean-Michel Oppert, Adriana Torcivia, Jean-Luc Bouillot, Valerie Paradis, Vlad Ratziu, Karine Clément
Publicado en: Gut, Edición 66/9, 2017, Página(s) 1688-1696, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312238

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

Autores: Panu K. Luukkonen, Sanja Sädevirta, You Zhou, Brandon Kayser, Ashfaq Ali, Linda Ahonen, Susanna Lallukka, Véronique Pelloux, Melania Gaggini, Ching Jian, Antti Hakkarainen, Nina Lundbom, Helena Gylling, Anne Salonen, Matej Orešič, Tuulia Hyötyläinen, Marju Orho-Melander, Aila Rissanen, Amalia Gastaldelli, Karine Clément, Leanne Hodson, Hannele Yki-Järvinen
Publicado en: Diabetes Care, Edición 41/8, 2018, Página(s) 1732-1739, ISSN 0149-5992
Editor: American Diabetes Association
DOI: 10.2337/dc18-0071

Genetics of alcoholic liver disease and non-alcoholic steatohepatitis

Autores: Emma Scott, Quentin M Anstee
Publicado en: Clinical Medicine, Edición 18/Suppl 2, 2018, Página(s) s54-s59, ISSN 1470-2118
Editor: Royal College of Physicians
DOI: 10.7861/clinmedicine.18-2-s54

Liver fibrosis: Direct antifibrotic agents and targeted therapies

Autores: Detlef Schuppan, Muhammad Ashfaq-Khan, Ai Ting Yang, Yong Ook Kim
Publicado en: Matrix Biology, Edición 68-69, 2018, Página(s) 435-451, ISSN 0945-053X
Editor: Elsevier BV
DOI: 10.1016/j.matbio.2018.04.006

Fibrosis and alcohol-related liver disease

Autores: Carolin Lackner, Dina Tiniakos
Publicado en: Journal of Hepatology, Edición 70/2, 2019, Página(s) 294-304, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2018.12.003

A spotlight on pathogenesis, interactions and novel therapeutic options in NAFLD

Autores: Ramy Younes, Elisabetta Bugianesi
Publicado en: Nature Reviews Gastroenterology & Hepatology, Edición 16/2, 2019, Página(s) 80-82, ISSN 1759-5045
Editor: Nature Publishing Group
DOI: 10.1038/s41575-018-0094-6

P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates

Autores: Sergio Rodriguez-Cuenca, Stefania Carobbio, Gwendolyn Barceló-Coblijn, Xavier Prieur, Joana Relat, Ramon Amat, Mark Campbell, Ana Rita Dias, Myriam Bahri, Sarah L. Gray, Antonio Vidal-Puig
Publicado en: Diabetes, Obesity and Metabolism, Edición 20/10, 2018, Página(s) 2339-2350, ISSN 1462-8902
Editor: Blackwell Publishing Inc.
DOI: 10.1111/dom.13370

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Autores: Konstantin Kazankov, Simon Mark Dahl Jørgensen, Karen Louise Thomsen, Holger Jon Møller, Hendrik Vilstrup, Jacob George, Detlef Schuppan, Henning Grønbæk
Publicado en: Nature Reviews Gastroenterology & Hepatology, Edición 16/3, 2019, Página(s) 145-159, ISSN 1759-5045
Editor: Nature Publishing Group
DOI: 10.1038/s41575-018-0082-x

Assessment of liver fibrosis progression and regression by a serological collagen turnover profile

Autores: Morten A. Karsdal, Sara T. Hjuler, Yi Luo, Daniel G. K. Rasmussen, Mette J. Nielsen, Signe Holm Nielsen, Diana J. Leeming, Zachary Goodman, Robert H. Arch, Keyur Patel, Detlef Schuppan
Publicado en: American Journal of Physiology-Gastrointestinal and Liver Physiology, Edición 316/1, 2019, Página(s) G25-G31, ISSN 0193-1857
Editor: American Physiological Society
DOI: 10.1152/ajpgi.00158.2018

From NASH to HCC: current concepts and future challenges

Autores: Quentin M. Anstee, Helen L. Reeves, Elena Kotsiliti, Olivier Govaere, Mathias Heikenwalder
Publicado en: Nature Reviews Gastroenterology & Hepatology, Edición 16/7, 2019, Página(s) 411-428, ISSN 1759-5045
Editor: Nature Publishing Group
DOI: 10.1038/s41575-019-0145-7

Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis

Autores: Geoff Farrell, Jörn M. Schattenberg, Isabelle Leclercq, Matthew M. Yeh, Robert Goldin, Narci Teoh, Detlef Schuppan
Publicado en: Hepatology, Edición 69/5, 2019, Página(s) 2241-2257, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.30333

Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity

Autores: Brandon D. Kayser, Marie Lhomme, Edi Prifti, Carla Da Cunha, Florian Marquet, Florian Chain, Isabelle Naas, Véronique Pelloux, Maria-Carlota Dao, Anatol Kontush, Salwa W. Rizkalla, Judith Aron-Wisnewsky, Luis G. Bermúdez-Humarán, Fiona Oakley, Philippe Langella, Karine Clément, Isabelle Dugail
Publicado en: The FASEB Journal, Edición 33/4, 2019, Página(s) 4741-4754, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201801897r

Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program

Autores: Yvonne Huber, Daniel Pfirrmann, Ines Gebhardt, Christian Labenz, Nadine Gehrke, Beate K. Straub, Christian Ruckes, Heike Bantel, Eugenio Belda, Karine Clément, Diana J. Leeming, Morten A. Karsdal, Peter R. Galle, Perikles Simon, Jörn M. Schattenberg
Publicado en: Alimentary Pharmacology & Therapeutics, Edición 50/8, 2019, Página(s) 930-939, ISSN 0269-2813
Editor: Blackwell Publishing Inc.
DOI: 10.1111/apt.15427

qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Steatohepatitis

Autores: Feng Liu, George Boon‐Bee Goh, Dina Tiniakos, Aileen Wee, Wei‐Qiang Leow, Jing‐Min Zhao, Hui‐Ying Rao, Xiao‐Xiao Wang, Qin Wang, Wei‐Keat Wan, Kiat‐Hon Lim, Manuel Romero‐Gomez, Salvatore Petta, Elisabetta Bugianesi, Chee‐Kiat Tan, Stephen A. Harrison, Quentin M. Anstee, Pik‐Eu Jason Chang, Lai Wei
Publicado en: Hepatology, 2019, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.30986

Lipidomes in health and disease: Analytical strategies and considerations

Autores: Fang Wei, Santosh Lamichhane, Matej Orešič, Tuulia Hyötyläinen
Publicado en: TrAC Trends in Analytical Chemistry, Edición 120, 2019, Página(s) 115664, ISSN 0165-9936
Editor: Elsevier BV
DOI: 10.1016/j.trac.2019.115664

Performance of the PRO-C3 collagen neo-epitope biomarker in non-alcoholic fatty liver disease

Autores: Marie Boyle, Dina Tiniakos, Jorn M. Schattenberg, Vlad Ratziu, Elisabetta Bugianessi, Salvatore Petta, Claudia P. Oliveira, Olivier Govaere, Ramy Younes, Stuart McPherson, Pierre Bedossa, Mette J Nielsen, Morten Karsdal, Diana Leeming, Stuart Kendrick, Quentin M. Anstee
Publicado en: JHEP Reports, Edición 1/3, 2019, Página(s) 188-198, ISSN 2589-5559
Editor: Elsevier B.V.
DOI: 10.1016/j.jhepr.2019.06.004

Voluntary exercise in mice fed an obesogenic diet alters the hepatic immune phenotype and improves metabolic parameters – an animal model of life style intervention in NAFLD

Autores: Nadine Gehrke, Jana Biedenbach, Yvonne Huber, Beate K. Straub, Peter R. Galle, Perikles Simon, Jörn M. Schattenberg
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-38321-9

Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites

Autores: You Zhou, Matej Orešič, Marja Leivonen, Peddinti Gopalacharyulu, Jenni Hyysalo, Johanna Arola, An Verrijken, Sven Francque, Luc Van Gaal, Tuulia Hyötyläinen, Hannele Yki-Järvinen
Publicado en: Clinical Gastroenterology and Hepatology, Edición 14/10, 2016, Página(s) 1463-1472.e6, ISSN 1542-3565
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cgh.2016.05.046

Heterogeneity of non-alcoholic fatty liver disease

Autores: Hannele Yki-Järvinen, Panu K. Luukkonen
Publicado en: Liver International, Edición 35/12, 2015, Página(s) 2498-2500, ISSN 1478-3223
Editor: Blackwell Publishing Inc.
DOI: 10.1111/liv.12970

Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study

Autores: Salvatore Petta, Mohammed Eslam, Luca Valenti, Elisabetta Bugianesi, Marco Barbara, Calogero Cammà, Marianna Porzio, Chiara Rosso, Silvia Fargion, Jacob George, Antonio Craxì
Publicado en: Liver International, Edición 37/9, 2017, Página(s) 1389-1396, ISSN 1478-3223
Editor: Blackwell Publishing Inc.
DOI: 10.1111/liv.13397

Non-pharmacological interventions in non-alcoholic fatty liver disease patients

Autores: Vlad Ratziu
Publicado en: Liver International, Edición 37, 2017, Página(s) 90-96, ISSN 1478-3223
Editor: Blackwell Publishing Inc.
DOI: 10.1111/liv.13311

The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems

Autores: Lucette Flandroy, Theofilos Poutahidis, Gabriele Berg, Gerard Clarke, Maria-Carlota Dao, Ellen Decaestecker, Eeva Furman, Tari Haahtela, Sébastien Massart, Hubert Plovier, Yolanda Sanz, Graham Rook
Publicado en: Science of The Total Environment, Edición 627, 2018, Página(s) 1018-1038, ISSN 0048-9697
Editor: Elsevier BV
DOI: 10.1016/j.scitotenv.2018.01.288

Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants

Autores: Gemma F. Codner, Joffrey Mianné, Adam Caulder, Jorik Loeffler, Rachel Fell, Ruairidh King, Alasdair J. Allan, Matthew Mackenzie, Fran J. Pike, Christopher V. McCabe, Skevoulla Christou, Sam Joynson, Marie Hutchison, Michelle E. Stewart, Saumya Kumar, Michelle M. Simon, Loranne Agius, Quentin M. Anstee, Kirill E. Volynski, Dimitri M. Kullmann, Sara Wells, Lydia Teboul
Publicado en: BMC Biology, Edición 16/1, 2018, ISSN 1741-7007
Editor: BioMed Central
DOI: 10.1186/s12915-018-0530-7

NASH in Lean Individuals

Autores: Ramy Younes, Elisabetta Bugianesi
Publicado en: Seminars in Liver Disease, Edición 39/01, 2019, Página(s) 086-095, ISSN 0272-8087
Editor: Thieme Medical Publishers
DOI: 10.1055/s-0038-1677517

Metabolic Modeling of Human Gut Microbiota on a Genome Scale: An Overview

Autores: Partho Sen, Matej Orešič
Publicado en: Metabolites, Edición 9/2, 2019, Página(s) 22, ISSN 2218-1989
Editor: MDPI
DOI: 10.3390/metabo9020022

From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options

Autores: Amalia Gastaldelli, Kenneth Cusi
Publicado en: JHEP Reports, Edición 1/4, 2019, Página(s) 312-328, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2019.07.002

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Autores: Olivier Govaere, Simon Cockell, Dina Tiniakos, Rachel Queen, Ramy Younes, Michele Vacca, Leigh Alexander, Federico Ravaioli, Jeremy Palmer, Salvatore Petta, Jerome Boursier, Chiara Rosso, Katherine Johnson, Kristy Wonders, Christopher P. Day, Mattias Ekstedt, Matej Orešič, Rebecca Darlay, Heather J. Cordell, Fabio Marra, Antonio Vidal-Puig, Pierre Bedossa, Jörn M. Schattenberg, Karine Clément,
Publicado en: Science Translational Medicine, Edición 12/572, 2020, Página(s) eaba4448, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aba4448

Editorial: hepatocellular carcinoma in non-cirrhotic NASH-a troubling reality

Autores: Marie Boyle, Quentin M. Anstee
Publicado en: Alimentary Pharmacology & Therapeutics, Edición 48/9, 2018, Página(s) 1021-1023, ISSN 0269-2813
Editor: Blackwell Publishing Inc.
DOI: 10.1111/apt.14982

Editorial: collagen proportionate area as a prognostic indicator in NAFLD

Autores: Federico Ravaioli, Quentin M. Anstee
Publicado en: Alimentary Pharmacology & Therapeutics, Edición 49/11, 2019, Página(s) 1452-1454, ISSN 0269-2813
Editor: Blackwell Publishing Inc.
DOI: 10.1111/apt.15249

Bile acids composition modulate insulin resistance in non-diabetic patients with NAFLD

Autores: Rosso, C.; Younes, R.; Eslam, M.; Chen, Fw.; Cucco, M.; Gaggini, M.; Coulter, S.; Carli, F.; Barbieri, C.; della Latta, V.; Abate, M. L.; Saracco, Gm.; Gastaldelli, A.; George, J.; Bugianesi, E.
Publicado en: Edición 21, 2018
Editor: Elsevier Inc.

Predisposition to diabetes is related to insulin resistance in NAFLD patients and to decreased insulin secretion in HCV patients

Autores: Pierantonelli, G. Svegliati-Baroni I.; Younes, R.; Rosso, C.; Rychlicki, C.; Bugianesi, E.; Gastaldelli, A.
Publicado en: Edición 5, 2018
Editor: Elsevier Inc.

In non obese NAFLD increased plasma saturated fatty acids and insulin resistance are metabolic signatures of severity of liver disease

Autores: Carli, F.; Gaggini, M.; Rosso, C.; Saponaro, C.; Barbieri, C.; Latta, V. D.; Buzzigoli, E.; Ciociaro, D.; Abate, M. L.; Marietti, M.; Younes, R.; Bugianesi, E.; Gastaldelli, A.
Publicado en: Edición 8, 2018
Editor: Elsevier Inc.

Hepatic macrophage activation is associated with adipose tissue insulin resistance in non-diabetic patients with Non-Alcoholic Fatty Liver Disease

Autores: Rosso, Chiara; Kazankov, K.; Marietti, Milena; Gaggini, M.; Buzzigoli, E.; Møller, H. J.; Caviglia, GIAN PAOLO; Abate, Maria Lorena; Smedile, Antonina; Saracco, Giorgio Maria; Vilstrup, H.; Gastaldelli, A.; George, J.; Grønbæk, H.; Bugianesi, Elisabetta
Publicado en: Edición 12, 2016
Editor: John Wiley & Sons, Inc.

Plasma Selenoprotein P levels are related to adipose tissue insulin resistance, composition of free fatty acids and liver fibrosis in non-diabetic patients with Non Alcoholic Fatty Liver Disease

Autores: Rosso, Chiara; Younes, Ramy; Fabrizia, Carli; Melania, Gaggini; Lavinia, Mezzabotta; Marietti, Milena; Federico, Salomone; Gambino, Roberto; Saba, Francesca; Emma, Buzzigoli; Demetrio, Ciociaro; Caviglia, GIAN PAOLO; Morello, Elisabetta; Abate, Maria Lorena; Smedile, Antonina; Ciancio, Alessia; Cassader, Maurizio; Saracco, Giorgio Maria; Amalia, Gastaldelli; Bugianesi, Elisabetta
Publicado en: Edición 9, 2017
Editor: John Wiey & Sons, Inc.

Insulin secretion and decreased glucose clearance are associated with enhanced fibrogenesis and a high risk of disease progression in non-diabetic patients with Non Alcoholic Fatty Liver Disease

Autores: Younes, Ramy; Rosso, Chiara; Melania, Gaggini; Lavinia, Mezzabotta; Marietti, Milena; Fabrizia, Carli; Federico, Salomone; Emma, Buzzigoli; Caviglia, GIAN PAOLO; Chiara, Barbieri; Abate, Maria Lorena; Smedile, Antonina; Saracco, Giorgio Maria; Anstee, Quentin M.; Leeming, Diana J.; Amalia, Gastaldelli; Detlef, Schuppan; Bugianesi, Elisabetta
Publicado en: Edición 9, 2017
Editor: John Wiley & Sons, Inc.

Hepatocellular carcinoma and metabolic risk factors in a main reference center in Italy

Autores: Younes, R; Rosso, C; Marietti, M; Caviglia, Gp; Nascè, A; Campion, D; Cantamessa, A; Carucci, P; Bugianesi, E
Publicado en: Edición 9, 2017
Editor: Elsevier Inc.

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