Descripción del proyecto
Un marco basado en la resonancia magnética nuclear mejora el diagnóstico de los trastornos neurológicos
La resonancia magnética nuclear (RMN) es el método de obtención de imágenes habitual para el diagnóstico y seguimiento de muchas enfermedades neurológicas como la esclerosis múltiple. Sin embargo, su aplicación en la práctica clínica se limita sobre todo a la identificación visual de anomalías tisulares notables, más que de las sutiles. El objetivo principal del equipo que integra el proyecto CDS-QUAMRI, financiado con fondos europeos, es desarrollar un sistema de apoyo a la toma de decisiones clínicas que aproveche el poder de la RMN en el diagnóstico de trastornos neurológicos y psiquiátricos, el cual a menudo carece de criterios objetivos. El consorcio integrará distintas modalidades de RMN y aprendizaje automático en un único marco. El sistema se centrará inicialmente en la depresión mayor y la esclerosis múltiple, con miras a servir de base para futuras decisiones clínicas en neurociencia.
Objetivo
A large number of neurological and psychiatric disorders lack objective criteria for primary diagnoses, early differential diagnosis with regard to subtypes in treatment response and disease progression or effective therapy monitoring resulting in a tremendous negative socio-economic impact. Scientific studies based on advanced MRI methods indicate that related patients show specific subtle changes in multiple MRI readouts that are only detectable by quantitative approaches. Existing tools for MRI data analysis are largely insufficient to maximise the use of advanced modality based, diverse and complex MRI data with deficiencies existing mainly in interoperability as well as data organisation, integration, analysis and exploitation in clinical decision making.
Hence, the development of a clinical decision support system for neurological and psychiatric disorders is envisioned that is based on multimodal quantitative magnetic resonance imaging, advanced feature extraction and multi-parametric classification. To that the quantitative analysis of structural, functional and metabolic MRI data (11 modalities) shall be fully integrated into a single software framework for the first time; support of large data, interoperability and access for non-expert users shall be enabled and a machine learning based classification module shall be developed. The quantification and feature extraction algorithms for metabolic, perfusion, diffusion and functional imaging shall be enhanced to access the full information content of the data independent of vendor specific scan protocols as required for future use in diagnostics, stratification and monitoring of patients. The envisioned clinical decision support system shall be tested, optimized and demonstrated for major depression and multiple sclerosis, but can be extended to additional disorders by enabling large scale clinical trials and more widespread use in neuroscience as a basis for the future clinical decision making.
Ámbito científico
- medical and health sciencesclinical medicinepsychiatryobsessive-compulsive disorder
- medical and health sciencesclinical medicinepsychiatryposttraumatic stress disorder
- medical and health sciencesbasic medicineneurologymultiple sclerosis
- engineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging
- medical and health sciencesclinical medicinepsychiatryschizophrenia
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-PHC-2014-two-stage
Régimen de financiación
RIA - Research and Innovation actionCoordinador
80539 Munchen
Alemania