Professional cross-priming for ovary and prostate cancer

Livrables

Report on the Annual Meetings (agenda, minutes, progress report) with all participants of the consortium including the EC Scientific Officer

The participants will meet annually to review the project’s progress and achievement and discuss coming activities. Five meetings will be placed: kick off, mid-terms and final meeting. Coordination and organisation of PROCROP meetings, and the preparation and distribution of the minutes of the SC will also be distributed.

Report of press release and dissemination activities concerning PROCROP project

The Coordinate will create a final report containing PROCROP press releases and dissemination activities in order to inform the general public. Of course, PROCROP will also include information about its activities on the webpage informing about the partners and its activities.

PROCROP Logo, graphical Chart and webpage

Design of the official PROCROP logo and graphical chart to generate visual identity for the project. Also, an official webpage will be created for PROCROP, to inform public and scientific community about different issues related to the project.

Publications in reviewed journals and conference abstracts.

Knowledge and publications in international high impact-factor journals (in the field of cancer and immunology). Reports of clinical trial outcomes with immunomonitoring results should result in reports submitted to the top clinical journals, either general, or specialized in oncology, given the expected efficacy and the novelty of the PROCROP approach. It is expected that the whole consortium will publish a total number of 8-15 papers, including reviews.

Knowledge/information management updated

Ensuring that all participants are informed of the strategy, aims and project development. Knowledge management activities will include the set-up of the web-based management platform – (member restricted access) for sharing information among all partners. The web-based will be the repository for all PROCROP documents restricted to consortium members.

Publications

Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation

Auteurs: Carlos del Fresno, Salvador Iborra, Paula Saz-Leal, María Martínez-López, David Sancho
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2018.00804

Dectin-1/2–induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses

Auteurs: Maria M. M. Kaisar, Manuel Ritter, Carlos del Fresno, Hulda S. Jónasdóttir, Alwin J. van der Ham, Leonard R. Pelgrom, Gabriele Schramm, Laura E. Layland, David Sancho, Clarissa Prazeres da Costa, Martin Giera, Maria Yazdanbakhsh, Bart Everts
Publié dans: PLOS Biology, Numéro 16/4, 2018, Page(s) e2005504, ISSN 1545-7885
Éditeur: PLOS
DOI: 10.1371/journal.pbio.2005504

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

Auteurs: Michel Enamorado, Salvador Iborra, Elena Priego, Francisco J. Cueto, Juan A. Quintana, Sarai Martínez-Cano, Ernesto Mejías-Pérez, Mariano Esteban, Ignacio Melero, Andrés Hidalgo, David Sancho
Publié dans: Nature Communications, Numéro 8, 2017, Page(s) 16073, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/ncomms16073

Innate Immune Function of Mitochondrial Metabolism

Auteurs: David Sancho, Michel Enamorado, Johan Garaude
Publié dans: Frontiers in Immunology, Numéro 8, 2017, ISSN 1664-3224
Éditeur: Frontiers Media S.A
DOI: 10.3389/fimmu.2017.00527

Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4–1BB)

Auteurs: Arantza Azpilikueta, Elixabet Bolaños, Valerie Lang, Sara Labiano, Maria A. Aznar, Iñaki Etxeberria, Alvaro Teijeira, Maria E. Rodriguez-Ruiz, Jose L. Perez-Gracia, Maria Jure-Kunkel, Juan M. Zapata, Manuel S. Rodriguez, Ignacio Melero
Publié dans: OncoImmunology, Numéro 7/1, 2017, Page(s) e1368605, ISSN 2162-402X
Éditeur: National Center for Biotechnology Information, U.S. National Library of Medicine
DOI: 10.1080/2162402X.2017.1368605

Antitumor effect of an adeno-associated virus expressing apolipoprotein A-1 fused to interferon alpha in an interferon alpha-resistant murine tumor model

Auteurs: Marcos Vasquez, Vladimir Paredes-Cervantes, Fernando Aranda, Nuria Ardaiz, Celia Gomar, Pedro Berraondo
Publié dans: Oncotarget, Numéro 8/3, 2017, ISSN 1949-2553
Éditeur: Impact Journals
DOI: 10.18632/oncotarget.14127

Immune Curbing of Cancer Stem Cells by CTLs Directed to NANOG

Auteurs: Christina Wefers, Gerty Schreibelt, Leon F. A. G. Massuger, I. Jolanda M. de Vries, Ruurd Torensma
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: National Center for Biotechnology Information, U.S. National Library of Medicine
DOI: 10.3389/fimmu.2018.01412

Different Lipid Regulation in Ovarian Cancer: Inhibition of the Immune System

Auteurs: Christina Wefers, Tjitske Duiveman-de Boer, Petra Zusterzeel, Leon Massuger, David Fuchs, Ruurd Torensma, Craig Wheelock, I. de Vries
Publié dans: International Journal of Molecular Sciences, Numéro 19/1, 2018, Page(s) 273, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19010273

Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells

Auteurs: A. R. Sanchez-Paulete, F. J. Cueto, M. Martinez-Lopez, S. Labiano, A. Morales-Kastresana, M. E. Rodriguez-Ruiz, M. Jure-Kunkel, A. Azpilikueta, M. A. Aznar, J. I. Quetglas, D. Sancho, I. Melero
Publié dans: Cancer Discovery, Numéro 6/1, 2016, Page(s) 71-79, ISSN 2159-8274
Éditeur: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.CD-15-0510

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

Auteurs: Johan Garaude, Rebeca Acín-Pérez, Sarai Martínez-Cano, Michel Enamorado, Matteo Ugolini, Estanislao Nistal-Villán, Sandra Hervás-Stubbs, Pablo Pelegrín, Leif E Sander, José A Enríquez, David Sancho
Publié dans: Nature Immunology, Numéro 17/9, 2016, Page(s) 1037-1045, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/ni.3509

Making the Most of Cancer Surgery with Neoadjuvant Immunotherapy

Auteurs: I. Melero, P. Berraondo, M. E. Rodriguez-Ruiz, J. L. Perez-Gracia
Publié dans: Cancer Discovery, Numéro 6/12, 2016, Page(s) 1312-1314, ISSN 2159-8274
Éditeur: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.CD-16-1109

Anti-CD137 monoclonal antibodies and adoptive T cell therapy: a perfect marriage?

Auteurs: Bettina Weigelin, Elixabet Bolaños, Maria E. Rodriguez-Ruiz, Ivan Martinez-Forero, Peter Friedl, Ignacio Melero
Publié dans: Cancer Immunology, Immunotherapy, Numéro 65/5, 2016, Page(s) 493-497, ISSN 0340-7004
Éditeur: Springer Verlag
DOI: 10.1007/s00262-016-1818-5

Interferon alpha bioactivity critically depends on Scavenger receptor class B type I function

Auteurs: Marcos Vasquez, Jessica Fioravanti, Fernando Aranda, Vladimir Paredes, Celia Gomar, Nuria Ardaiz, Veronica Fernandez-Ruiz, Miriam Méndez, Estanislao Nistal-Villan, Esther Larrea, Qinshan Gao, Gloria Gonzalez-Aseguinolaza, Jesus Prieto, Pedro Berraondo
Publié dans: OncoImmunology, Numéro 5/8, 2016, Page(s) e1196309, ISSN 2162-402X
Éditeur: Taylor Francis Group
DOI: 10.1080/2162402X.2016.1196309

Harnessing RNA sequencing for global, unbiased evaluation of two new adjuvants for dendritic-cell immunotherapy

Auteurs: Till S.M. Mathan, Johannes Textor, Annette E. Sköld, Inge Reinieren-Beeren, Tom van Oorschot, Mareke Brüning, Carl G. Figdor, Sonja I. Buschow, Ghaith Bakdash, I. Jolanda M. de Vries
Publié dans: Oncotarget, 2017, ISSN 1949-2553
Éditeur: Impact Journals
DOI: 10.18632/oncotarget.15190

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