Common Oncogenic Mechanisms in Multi-Partner Translocation Families in Acute Myeloid Leukemia

Informazioni relative al progetto

ONCOMECHAML

ID dell’accordo di sovvenzione: 636855

DOI 10.3030/636855

Progetto chiuso

Data della firma CE 28 Maggio 2015

Data di avvio 1 Giugno 2015

Data di completamento 31 Maggio 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 499 500,00

Contributo UE € 1 499 500,00

Coordinato da

VETERINAERMEDIZINISCHE UNIVERSITAET WIEN
Austria

Pubblicazioni

Peer reviewed articles (14)

JAK-STAT signaling in cancer: From cytokines to non-coding genome

Autori: Jan Pencik, Ha Thi Thanh Pham, Johannes Schmoellerl, Tahereh Javaheri, Michaela Schlederer, Zoran Culig, Olaf Merkel, Richard Moriggl, Florian Grebien, Lukas Kenner
Pubblicato in: Cytokine, Numero 87, 2016, Pagina/e 26-36, ISSN 1043-4666
Editore: Academic Press
DOI: 10.1016/j.cyto.2016.06.017

Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells

Autori: Katrin Noack, Nisintha Mahendrarajah, Dorle Hennig, Luisa Schmidt, Florian Grebien, Dagmar Hildebrand, Markus Christmann, Bernd Kaina, Andreas Sellmer, Siavosh Mahboobi, Katharina Kubatzky, Thorsten Heinzel, Oliver H. Krämer
Pubblicato in: Archives of Toxicology, Numero 91/5, 2017, Pagina/e 2191-2208, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-016-1878-5

NVT: a fast and simple tool for the assessment of RNA-seq normalization strategies

Autori: Thomas Eder, Florian Grebien, Thomas Rattei
Pubblicato in: Bioinformatics, 2016, Pagina/e btw521, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btw521

STAT5BN642H is a driver mutation for T cell neoplasia

Autori: Ha Thi Thanh Pham, Barbara Maurer, Michaela Prchal-Murphy, Reinhard Grausenburger, Eva Grundschober, Tahereh Javaheri, Harini Nivarthi, Auke Boersma, Thomas Kolbe, Mohamed Elabd, Florian Halbritter, Jan Pencik, Zahra Kazemi, Florian Grebien, Markus Hengstschläger, Lukas Kenner, Stefan Kubicek, Matthias Farlik, Christoph Bock, Peter Valent, Mathias Müller, Thomas Rülicke, Veronika Sexl, Richard
Pubblicato in: Journal of Clinical Investigation, Numero 128/1, 2018, Pagina/e 387-401, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/JCI94509

SETD2 in MLL-rearranged leukemia – a complex case

Autori: Anna Skucha, Jessica Ebner, Florian Grebien
Pubblicato in: Molecular & Cellular Oncology, Numero 5/4, 2018, Pagina/e e1503492, ISSN 2372-3556
Editore: Taylor & Francis Group
DOI: 10.1080/23723556.2018.1503492

CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex

Autori: Luisa Schmidt, Elizabeth Heyes, Lisa Scheiblecker, Thomas Eder, Giacomo Volpe, Jon Frampton, Claus Nerlov, Peter Valent, Jolanta Grembecka, Florian Grebien
Pubblicato in: Leukemia, 2019, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-019-0382-3

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

Autori: Anna Skucha, Jessica Ebner, Johannes Schmöllerl, Mareike Roth, Thomas Eder, Adrián César-Razquin, Alexey Stukalov, Sarah Vittori, Matthias Muhar, Bin Lu, Martin Aichinger, Julian Jude, André C. Müller, Balázs Győrffy, Christopher R. Vakoc, Peter Valent, Keiryn L. Bennett, Johannes Zuber, Giulio Superti-Furga, Florian Grebien
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-04329-y

Oxytocin‐like signaling in ants influences metabolic gene expression and locomotor activity

Autori: Zita Liutkevičiūte, Esther Gil‐Mansilla, Thomas Eder, Barbara Casillas‐Pérez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, Thomas Rattei, Markus Muttenthaler, Sylvia Cremer, Christian W. Gruber
Pubblicato in: The FASEB Journal, Numero 32/12, 2018, Pagina/e 6808-6821, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201800443

Altered splicing and cytoplasmic levels of tRNA synthetases in SF3B1-mutant myelodysplastic syndromes as a therapeutic vulnerability

Autori: Fabio Giuseppe Liberante, Katrina Lappin, Eliana M. Barros, Jekaterina Vohhodina, Florian Grebien, Kienan I. Savage, Kenneth Ian Mills
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-39591-7

Roles of SETD2 in Leukemia—Transcription, DNA-Damage, and Beyond

Autori: Anna Skucha, Jessica Ebner, Florian Grebien
Pubblicato in: International Journal of Molecular Sciences, Numero 20/5, 2019, Pagina/e 1029, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20051029

Dependence on Myb expression is attenuated in myeloid leukaemia with N-terminal CEBPA mutations

Autori: Giacomo Volpe, Pierre Cauchy, David S Walton, Carl Ward, Daniel Blakemore, Rachael Bayley, Mary L Clarke, Luisa Schmidt, Claus Nerlov, Paloma Garcia, Stéphanie Dumon, Florian Grebien, Jon Frampton
Pubblicato in: Life Science Alliance, Numero 2/2, 2019, Pagina/e e201800207, ISSN 2575-1077
Editore: Life Science Alliance
DOI: 10.26508/lsa.201800207

STAT3β is a tumor suppressor in acute myeloid leukemia

Autori: Petra Aigner, Tatsuaki Mizutani, Jaqueline Horvath, Thomas Eder, Stefan Heber, Karin Lind, Valentin Just, Herwig P. Moll, Assa Yeroslaviz, Michael J. M. Fischer, Lukas Kenner, Balázs Győrffy, Heinz Sill, Florian Grebien, Richard Moriggl, Emilio Casanova, Dagmar Stoiber
Pubblicato in: Blood Advances, Numero 3/13, 2019, Pagina/e 1989-2002, ISSN 2473-9529
Editore: American Society of Hematology
DOI: 10.1182/bloodadvances.2018026385

Gain‐of‐Function Effects of N‐Terminal CEBPA Mutations in Acute Myeloid Leukemia

Autori: Luisa Schmidt, Elizabeth Heyes, Florian Grebien
Pubblicato in: BioEssays, Numero 42/2, 2020, Pagina/e 1900178, ISSN 0265-9247
Editore: John Wiley & Sons Inc.
DOI: 10.1002/bies.201900178

CDK6 is an essential direct target of NUP98-fusion proteins in acute myeloid leukemia

Autori: Johannes Schmoellerl, Inês Amorim Monteiro Barbosa, Thomas Eder, Tania Brandstoetter, Luisa Schmidt, Barbara Maurer, Selina Troester, Ha Thi Thanh Pham, Mohanty Sagarajit, Jessica Ebner, Gabriele Manhart, Ezgi Aslan, Stefan Terlecki-Zaniewicz, Christa Van der Veen, Gregor Hoermann, Nicolas Duployez, Arnaud Petit, Helene Lapillonne, Alexandre Puissant, Raphaël A. Itzykson, Richard H Moriggl, Mich
Pubblicato in: Blood, 2020, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2019003267