Safeguarding Cell Identities: Mechanisms Counteracting Cell Fate Reprogramming

Project Information

REPROWORM

Grant agreement ID: 637530

DOI 10.3030/637530

Project closed

EC signature date 5 February 2015

Start date 1 March 2015

End date 28 February 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 457 938,00

EU contribution € 1 457 938,00

Coordinated by

MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
Germany

Publications

Peer reviewed articles (12)

The CONJUDOR pipeline for multiplexed knockdown of gene pairs identifies RBBP-5 as a germ cell reprogramming barrier in C. elegans

Author(s): Marlon Kazmierczak, Carlota Farré i Díaz, Andreas Ofenbauer, Sergej Herzog, Baris Tursun
Published in: Nucleic Acids Research, Issue 49/4, 2020, Page(s) e22-e22, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa1171

Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons

Author(s): Stefanie Seelk, Irene Adrian-Kalchhauser, Balázs Hargitai, Martina Hajduskova, Silvia Gutnik, Baris Tursun, Rafal Ciosk
Published in: eLife, Issue 5, 2016, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.15477

FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells

Author(s): Ena Kolundzic, Andreas Ofenbauer, Selman I. Bulut, Bora Uyar, Gülkiz Baytek, Anne Sommermeier, Stefanie Seelk, Mei He, Antje Hirsekorn, Dubravka Vucicevic, Altuna Akalin, Sebastian Diecke, Scott A. Lacadie, Baris Tursun
Published in: Developmental Cell, Issue 46/5, 2018, Page(s) 611-626.e12, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2018.07.006

The conserved histone chaperone LIN‐53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans

Author(s): Stefanie Müthel, Bora Uyar, Mei He, Anne Krause, Burcu Vitrinel, Selman Bulut, Djordje Vasiljevic, Iris Marchal, Stefan Kempa, Altuna Akalin, Baris Tursun
Published in: Aging Cell, 2019, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13012

MRG-1/MRG15 Is a Barrier for Germ Cell to Neuron Reprogramming in Caenorhabditis elegans

Author(s): Martina Hajduskova, Gülkiz Baytek, Ena Kolundzic, Alexander Gosdschan, Marlon Kazmierczak, Andreas Ofenbauer, Maria Lena Beato del Rosal, Sergej Herzog, Nida ul Fatima, Philipp Mertins, Stefanie Seelk-Müthel, Baris Tursun
Published in: Genetics, Issue 211/1, 2019, Page(s) 121-139, ISSN 0016-6731
Publisher: Genetics Society of America
DOI: 10.1534/genetics.118.301674

HOT or not: examining the basis of high-occupancy target regions

Author(s): Katarzyna Wreczycka, Vedran Franke, Bora Uyar, Ricardo Wurmus, Selman Bulut, Baris Tursun, Altuna Akalin
Published in: Nucleic Acids Research, Issue 47/11, 2019, Page(s) 5735-5745, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz460

Strategies for in vivo reprogramming

Author(s): Andreas Ofenbauer, Baris Tursun
Published in: Current Opinion in Cell Biology, Issue 61, 2019, Page(s) 9-15, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2019.06.002

Transdifferentiation: do transition states lie on the path of development?

Author(s): Anna Reid, Baris Tursun
Published in: Current Opinion in Systems Biology, Issue 11, 2018, Page(s) 18-23, ISSN 2452-3100
Publisher: Elsevier
DOI: 10.1016/j.coisb.2018.07.004

Determinants of promoter and enhancer transcription directionality in metazoans

Author(s): Mahmoud M. Ibrahim, Aslihan Karabacak, Alexander Glahs, Ena Kolundzic, Antje Hirsekorn, Alexa Carda, Baris Tursun, Robert P. Zinzen, Scott A. Lacadie, Uwe Ohler
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06962-z

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in <em>C. elegans</em>

Author(s): Ena Kolundzic, Stefanie Seelk, Baris Tursun
Published in: Journal of Visualized Experiments, Issue 131, 2018, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/56889

Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans

Author(s): Thomas Wilhelm, Jonathan Byrne, Rebeca Medina, Ena Kolundžić, Johannes Geisinger, Martina Hajduskova, Baris Tursun, Holger Richly
Published in: Genes & Development, Issue 31/15, 2017, Page(s) 1561-1572, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.301648.117

A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large

Author(s): Selma Waaijers, Javier Muñoz, Christian Berends, João J. Ramalho, Soenita S. Goerdayal, Teck Y. Low, Adja D. Zoumaro-Djayoon, Michael Hoffmann, Thijs Koorman, Roderick P. Tas, Martin Harterink, Stefanie Seelk, Jana Kerver, Casper C. Hoogenraad, Olaf Bossinger, Baris Tursun, Sander van den Heuvel, Albert J. R. Heck, Mike Boxem
Published in: BMC Biology, Issue 14/1, 2016, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-016-0286-x

Book chapters (1)

PcG Proteins in Caenorhabditis elegans

Author(s): B. Tursun
Published in: Polycomb Group Proteins, 2017, Page(s) 289-315, ISBN 9780-128097373
Publisher: Elsevier
DOI: 10.1016/b978-0-12-809737-3.00012-x

Other (1)

FACT sets a barrier for cell fate reprogramming in C. elegans and Human

Author(s): Ena Kolundzic, Andreas Ofenbauer, Bora Uyar, Anne Sommermeier, Stefanie Seelk, Mei He, Guelkiz Baytek, Altuna Akalin, Sebastian Diecke, Scott Allen Lacadie, Baris Tursun
Published in: bioRxiv, 2017
Publisher: CSHL
DOI: 10.1101/185116