Objective One of the challenges facing science is to understand the chemical origin of DNA damage-induced mutations. Upon exposure to UV light, DNA nucleobases become electronically excited. This process potentially favors mutagenic miscoding of the DNA sequence.The main target of STARLIGHT is to study with unprecedented temporal resolution (few-femtoseconds/attoseconds) the electron dynamics occurring in UV photoexcited biomolecules. I will mainly consider aromatic complexes including DNA nucleobases (and ultimately DNA) with the aim of tracking in real time the electron dynamics preceding structural changes potentially leading to damage. The proposed research is based on a bottom-up approach: it allows one to understand the physical origin of a variety of light-driven processes occurring in more complex biological systems of crucial importance in photochemistry and photobiology, with tremendous prospects in phototherapy.Electron motion in molecules occurs on a temporal scale ranging from few femtoseconds down to attoseconds. Attosecond science is nowadays a well-established field and electron dynamics has been successfully studied in atoms and small molecules. The work recently conducted by the PI has demonstrated that this technology is mature and ready to be applied to more complex systems such as biomolecules.Electron dynamics will be resonantly activated in biomolecules by few-cycle UV pump pulses and subsequently probed by as-XUV pulses or few-fs-UV pulses. Through time-resolved measurements of the molecular photo-fragmentation, gas-phase spectroscopy will be used to elucidate the role of electrons in the photoreactivity of the molecule in a solvent-free environment. With the final goal of steering the electronic motion, circularly polarized UV pulses will be also used to induce electronic currents in cyclic biomolecules. These ring currents can be exploited to generate intense magnetic fields with promising applications in molecular electronics and quantum control. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesnatural scienceschemical sciencesphysical chemistryphotochemistrynatural sciencesbiological sciencesgeneticsmutationnatural sciencesphysical sciencesopticslaser physics Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-StG-2014 - ERC Starting Grant Call for proposal ERC-2014-STG See other projects for this call Funding Scheme ERC-STG - Starting Grant Host institution DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY Net EU contribution € 812 500,00 Address NOTKESTRASSE 85 22607 Hamburg Germany See on map Region Hamburg Hamburg Hamburg Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 812 500,00 Beneficiaries (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY Germany Net EU contribution € 812 500,00 Address NOTKESTRASSE 85 22607 Hamburg See on map Region Hamburg Hamburg Hamburg Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 812 500,00 CONSIGLIO NAZIONALE DELLE RICERCHE Italy Net EU contribution € 684 500,00 Address PIAZZALE ALDO MORO 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 684 500,00