Biocompatible nanoparticles for T cell targeted siRNA delivery as novel asthma therapy

Project Information

Novel asthma therapy

Grant agreement ID: 637830

DOI

10.3030/637830

Project closed

EC signature date 23 July 2015

Start date 1 October 2015

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Book chapters (3)

Characterization Techniques for Studying the Properties of Nanocarriers for Systemic Delivery

Author(s): Aditi Mehta, Olivia M. Merkel
Published in: Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications, Issue 13, 2020, Page(s) 57-86, ISBN 978-3-030-54489-8
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-54490-4_3

Evaluating the Regulation of Cytokine Levels After siRNA Treatment in Antigen-Specific Target Cell Populations via Intracellular Staining

Author(s): Rima Kandil, Daniel Feldmann, Yuran Xie, Olivia M. Merkel
Published in: Handbook of Experimental Pharmacology, 2018, Page(s) 323-331
Publisher: Springer Berlin Heidelberg
DOI: 10.1007/978-1-4939-9092-4_21

A Method for Targeted Nonviral siRNA Delivery in Cancer and Inflammatory Diseases

Author(s): Rima Kandil, Yuran Xie, Aditi Mehta, Olivia Merkel
Published in: Drug Delivery Systems, Issue 2059, 2020, Page(s) 155-166, ISBN 978-1-4939-9797-8
Publisher: Springer New York
DOI: 10.1007/978-1-4939-9798-5_7

Peer reviewed articles (20)

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread

Author(s): Shubhankar Ambike, Cho-Chin Cheng, Martin Feuerherd, Stoyan Velkov, Domizia Baldassi, Suliman Qadir Afridi, Diana Porras-Gonzalez, Xin Wei, Philipp Hagen, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Vincent Grass , Gerald Burgstaller, Andreas Pichlmair, Olivia M Merkel, Chunkyu Ko , Thomas Michler
Published in: Nucleic Acids Research, 2021, ISSN 1362-4962
Publisher: oxford academics
DOI: 10.1093/nar/gkab1248

Intranasal drug delivery: opportunities and toxicologic challenges during drug development

Author(s): Lea-Adriana Keller, Olivia Merkel , Andreas Popp
Published in: Drug Delivery and Translational Research, 2021, ISSN 2190-3948
Publisher: springer international publication
DOI: 10.1007/s13346-020-00891-5

Air-liquid interface cultures of the healthy and diseased human respiratory tract: promises, challenges and future directions

Author(s): Domizia Baldassi, Bettina Gabold , Olivia Merkel
Published in: Advanced Nanobiomed Research, 2021, ISSN 2699-9307
Publisher: wiley
DOI: 10.1002/anbr.202000111

Impact of crystalline and amorphous matrices on successful spray drying of siRNA polyplexes for inhalation of nano-in-microparticles

Author(s): Tobias Wm Keil, Christoph Zimmermann , Domizia Baldassi, Friederike Adams , Wolfgang Friess, Aditi Mehta, Olivia M Merkel
Published in: Advanced Therapeutics, 2021, ISSN 2366-3987
Publisher: wiley
DOI: 10.1002/adtp.202100073

siRNA Therapeutics against Respiratory Viral Infections-What Have We Learned for Potential COVID-19 Therapies?

Author(s): Aditi Mehta , Thomas Michler, Olivia M Merkel
Published in: Advanced Healthcare Materials, 2021, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202001650

The impact of microfluidic mixing of triblock micelleplexes on in vitro $/$ in vivo gene silencing and intracellular trafficking

Author(s): Daniel P Feldmann, Yuran Xie, Steven K Jones, Dongyue Yu, Anna Moszczynska, Olivia M Merkel
Published in: Nanotechnology, Issue 28/22, 2017, Page(s) 224001, ISSN 0957-4484
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6528/aa6d15

Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy

Author(s): Elena Dalle Vedove, Gabriella Costabile, Olivia M. Merkel
Published in: Advanced Healthcare Materials, 2018, Page(s) 1701398, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201701398

In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells

Author(s): Daniel P. Feldmann, Yilong Cheng, Rima Kandil, Yuran Xie, Mariam Mohammadi, Hartmann Harz, Akhil Sharma, David J. Peeler, Anna Moszczynska, Heinrich Leonhardt, Suzie H. Pun, Olivia M. Merkel
Published in: Journal of Controlled Release, Issue 276, 2018, Page(s) 50-58, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2018.02.017

Recent progress of polymeric nanogels for gene delivery

Author(s): Rima Kandil, Olivia M. Merkel
Published in: Current Opinion in Colloid & Interface Science, Issue 39, 2019, Page(s) 11-23, ISSN 1359-0294
Publisher: Pergamon Press
DOI: 10.1016/j.cocis.2019.01.005

Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine

Author(s): Yuran Xie, Bryan Killinger, Anna Moszczynska, Olivia Merkel
Published in: Molecules, Issue 21/10, 2016, Page(s) 1334, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules21101334

Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma

Author(s): Yuran Xie, Na Hyung Kim, Venkatareddy Nadithe, Dana Schalk, Archana Thakur, Ayşe Kılıç, Lawrence G. Lum, David J.P. Bassett, Olivia M. Merkel
Published in: Journal of Controlled Release, Issue 229, 2016, Page(s) 120-129, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2016.03.029

Pulmonary Delivery of siRNA via Polymeric Vectors as Therapies of Asthma

Author(s): Yuran Xie, Olivia M. Merkel
Published in: Archiv der Pharmazie, Issue 348/10, 2015, Page(s) 681-688, ISSN 0365-6233
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ardp.201500120

Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution

Author(s): Qian Zhong, Olivia M. Merkel, Joshua J. Reineke, Sandro R. P. da Rocha
Published in: Molecular Pharmaceutics, Issue 13/6, 2016, Page(s) 1866-1878, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.6b00036

Immunogenicity of Cas9 Protein

Author(s): Aditi Mehta, Olivia M. Merkel
Published in: Journal of Pharmaceutical Sciences, Issue 109/1, 2020, Page(s) 62-67, ISSN 0022-3549
Publisher: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2019.10.003

Nanoparticle-Mediated Gene Silencing for Sensitization of Lung Cancer to Cisplatin Therapy

Author(s): Daniel P. Feldmann, Joshua Heyza, Christoph M. Zimmermann, Steve M. Patrick, Olivia M. Merkel
Published in: Molecules, Issue 25/8, 2020, Page(s) 1994, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25081994

T-cell targeted pulmonary siRNA delivery for the treatment of asthma

Author(s): Tobias W. M. Keil, Domizia Baldassi, Olivia M. Merkel
Published in: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2020, Page(s) e1634, ISSN 1939-5116
Publisher: wiley
DOI: 10.1002/wnan.1634

Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles

Author(s): Tobias W.M. Keil, Daniel P. Feldmann, Gabriella Costabile, Qian Zhong, Sandro da Rocha, Olivia M. Merkel
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 143, 2019, Page(s) 61-69, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2019.08.012

Coming in and Finding Out: Blending Receptor‐Targeted Delivery and Efficient Endosomal Escape in a Novel Bio‐Responsive siRNA Delivery System for Gene Knockdown in Pulmonary T Cells

Author(s): Rima Kandil, Yuran Xie, Ralf Heermann, Lorenz Isert, Kirsten Jung, Aditi Mehta, Olivia M. Merkel
Published in: Advanced Therapeutics, 2019, Page(s) 1900047, ISSN 2366-3987
Publisher: Weinh
DOI: 10.1002/adtp.201900047

Targeting KRAS Mutant Lung Cancer Cells with siRNA-Loaded Bovine Serum Albumin Nanoparticles

Author(s): Aditi Mehta, Elena Dalle Vedove, Lorenz Isert, Olivia M. Merkel
Published in: Pharmaceutical Research, Issue 36/9, 2019, ISSN 0724-8741
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-019-2665-9

Characterization of positively charged polyplexes by tunable resistive pulse sensing

Author(s): Tobias W.M. Keil, Olivia M. Merkel
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 158, 2021, Page(s) 359-364, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2020.12.010

Non-peer reviewed articles (2)

Pulmonary delivery of siRNA as a novel treatment for lung diseases

Author(s): Rima Kandil, Olivia M Merkel
Published in: Therapeutic Delivery, Issue 10/4, 2019, Page(s) 203-206, ISSN 2041-5990
Publisher: Future Science
DOI: 10.4155/tde-2019-0009

Dry powder inhalation of siRNA

Author(s): Tobias WM Keil, Olivia M Merkel
Published in: Therapeutic Delivery, Issue 10/5, 2019, Page(s) 265-267, ISSN 2041-5990
Publisher: Future Science
DOI: 10.4155/tde-2019-0018