Biocompatible nanoparticles for T cell targeted siRNA delivery as novel asthma therapy

Characterization Techniques for Studying the Properties of Nanocarriers for Systemic Delivery

Autorzy: Aditi Mehta, Olivia M. Merkel
Opublikowane w: Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications, Numer 13, 2020, Strona(/y) 57-86, ISBN 978-3-030-54489-8
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-030-54490-4_3

Evaluating the Regulation of Cytokine Levels After siRNA Treatment in Antigen-Specific Target Cell Populations via Intracellular Staining

Autorzy: Rima Kandil, Daniel Feldmann, Yuran Xie, Olivia M. Merkel
Opublikowane w: Handbook of Experimental Pharmacology, 2018, Strona(/y) 323-331
Wydawca: Springer Berlin Heidelberg
DOI: 10.1007/978-1-4939-9092-4_21

A Method for Targeted Nonviral siRNA Delivery in Cancer and Inflammatory Diseases

Autorzy: Rima Kandil, Yuran Xie, Aditi Mehta, Olivia Merkel
Opublikowane w: Drug Delivery Systems, Numer 2059, 2020, Strona(/y) 155-166, ISBN 978-1-4939-9797-8
Wydawca: Springer New York
DOI: 10.1007/978-1-4939-9798-5_7

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread

Autorzy: Shubhankar Ambike, Cho-Chin Cheng, Martin Feuerherd, Stoyan Velkov, Domizia Baldassi, Suliman Qadir Afridi, Diana Porras-Gonzalez, Xin Wei, Philipp Hagen, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Vincent Grass , Gerald Burgstaller, Andreas Pichlmair, Olivia M Merkel, Chunkyu Ko , Thomas Michler
Opublikowane w: Nucleic Acids Research, 2021, ISSN 1362-4962
Wydawca: oxford academics
DOI: 10.1093/nar/gkab1248

Intranasal drug delivery: opportunities and toxicologic challenges during drug development

Autorzy: Lea-Adriana Keller, Olivia Merkel , Andreas Popp
Opublikowane w: Drug Delivery and Translational Research, 2021, ISSN 2190-3948
Wydawca: springer international publication
DOI: 10.1007/s13346-020-00891-5

Air-liquid interface cultures of the healthy and diseased human respiratory tract: promises, challenges and future directions

Autorzy: Domizia Baldassi, Bettina Gabold , Olivia Merkel
Opublikowane w: Advanced Nanobiomed Research, 2021, ISSN 2699-9307
Wydawca: wiley
DOI: 10.1002/anbr.202000111

Impact of crystalline and amorphous matrices on successful spray drying of siRNA polyplexes for inhalation of nano-in-microparticles

Autorzy: Tobias Wm Keil, Christoph Zimmermann , Domizia Baldassi, Friederike Adams , Wolfgang Friess, Aditi Mehta, Olivia M Merkel
Opublikowane w: Advanced Therapeutics, 2021, ISSN 2366-3987
Wydawca: wiley
DOI: 10.1002/adtp.202100073

siRNA Therapeutics against Respiratory Viral Infections-What Have We Learned for Potential COVID-19 Therapies?

Autorzy: Aditi Mehta , Thomas Michler, Olivia M Merkel
Opublikowane w: Advanced Healthcare Materials, 2021, ISSN 2192-2659
Wydawca: World Scientific
DOI: 10.1002/adhm.202001650

The impact of microfluidic mixing of triblock micelleplexes on in vitro $/$ in vivo gene silencing and intracellular trafficking

Autorzy: Daniel P Feldmann, Yuran Xie, Steven K Jones, Dongyue Yu, Anna Moszczynska, Olivia M Merkel
Opublikowane w: Nanotechnology, Numer 28/22, 2017, Strona(/y) 224001, ISSN 0957-4484
Wydawca: Institute of Physics Publishing
DOI: 10.1088/1361-6528/aa6d15

Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy

Autorzy: Elena Dalle Vedove, Gabriella Costabile, Olivia M. Merkel
Opublikowane w: Advanced Healthcare Materials, 2018, Strona(/y) 1701398, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201701398

In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells

Autorzy: Daniel P. Feldmann, Yilong Cheng, Rima Kandil, Yuran Xie, Mariam Mohammadi, Hartmann Harz, Akhil Sharma, David J. Peeler, Anna Moszczynska, Heinrich Leonhardt, Suzie H. Pun, Olivia M. Merkel
Opublikowane w: Journal of Controlled Release, Numer 276, 2018, Strona(/y) 50-58, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2018.02.017

Recent progress of polymeric nanogels for gene delivery

Autorzy: Rima Kandil, Olivia M. Merkel
Opublikowane w: Current Opinion in Colloid & Interface Science, Numer 39, 2019, Strona(/y) 11-23, ISSN 1359-0294
Wydawca: Pergamon Press
DOI: 10.1016/j.cocis.2019.01.005

Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine

Autorzy: Yuran Xie, Bryan Killinger, Anna Moszczynska, Olivia Merkel
Opublikowane w: Molecules, Numer 21/10, 2016, Strona(/y) 1334, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules21101334

Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma

Autorzy: Yuran Xie, Na Hyung Kim, Venkatareddy Nadithe, Dana Schalk, Archana Thakur, Ayşe Kılıç, Lawrence G. Lum, David J.P. Bassett, Olivia M. Merkel
Opublikowane w: Journal of Controlled Release, Numer 229, 2016, Strona(/y) 120-129, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2016.03.029

Pulmonary Delivery of siRNA via Polymeric Vectors as Therapies of Asthma

Autorzy: Yuran Xie, Olivia M. Merkel
Opublikowane w: Archiv der Pharmazie, Numer 348/10, 2015, Strona(/y) 681-688, ISSN 0365-6233
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/ardp.201500120

Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution

Autorzy: Qian Zhong, Olivia M. Merkel, Joshua J. Reineke, Sandro R. P. da Rocha
Opublikowane w: Molecular Pharmaceutics, Numer 13/6, 2016, Strona(/y) 1866-1878, ISSN 1543-8384
Wydawca: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.6b00036

Immunogenicity of Cas9 Protein

Autorzy: Aditi Mehta, Olivia M. Merkel
Opublikowane w: Journal of Pharmaceutical Sciences, Numer 109/1, 2020, Strona(/y) 62-67, ISSN 0022-3549
Wydawca: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2019.10.003

Nanoparticle-Mediated Gene Silencing for Sensitization of Lung Cancer to Cisplatin Therapy

Autorzy: Daniel P. Feldmann, Joshua Heyza, Christoph M. Zimmermann, Steve M. Patrick, Olivia M. Merkel
Opublikowane w: Molecules, Numer 25/8, 2020, Strona(/y) 1994, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25081994

T-cell targeted pulmonary siRNA delivery for the treatment of asthma

Autorzy: Tobias W. M. Keil, Domizia Baldassi, Olivia M. Merkel
Opublikowane w: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2020, Strona(/y) e1634, ISSN 1939-5116
Wydawca: wiley
DOI: 10.1002/wnan.1634

Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles

Autorzy: Tobias W.M. Keil, Daniel P. Feldmann, Gabriella Costabile, Qian Zhong, Sandro da Rocha, Olivia M. Merkel
Opublikowane w: European Journal of Pharmaceutics and Biopharmaceutics, Numer 143, 2019, Strona(/y) 61-69, ISSN 0939-6411
Wydawca: Elsevier BV
DOI: 10.1016/j.ejpb.2019.08.012

Coming in and Finding Out: Blending Receptor‐Targeted Delivery and Efficient Endosomal Escape in a Novel Bio‐Responsive siRNA Delivery System for Gene Knockdown in Pulmonary T Cells

Autorzy: Rima Kandil, Yuran Xie, Ralf Heermann, Lorenz Isert, Kirsten Jung, Aditi Mehta, Olivia M. Merkel
Opublikowane w: Advanced Therapeutics, 2019, Strona(/y) 1900047, ISSN 2366-3987
Wydawca: Weinh
DOI: 10.1002/adtp.201900047

Targeting KRAS Mutant Lung Cancer Cells with siRNA-Loaded Bovine Serum Albumin Nanoparticles

Autorzy: Aditi Mehta, Elena Dalle Vedove, Lorenz Isert, Olivia M. Merkel
Opublikowane w: Pharmaceutical Research, Numer 36/9, 2019, ISSN 0724-8741
Wydawca: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-019-2665-9

Characterization of positively charged polyplexes by tunable resistive pulse sensing

Autorzy: Tobias W.M. Keil, Olivia M. Merkel
Opublikowane w: European Journal of Pharmaceutics and Biopharmaceutics, Numer 158, 2021, Strona(/y) 359-364, ISSN 0939-6411
Wydawca: Elsevier BV
DOI: 10.1016/j.ejpb.2020.12.010

Pulmonary delivery of siRNA as a novel treatment for lung diseases

Autorzy: Rima Kandil, Olivia M Merkel
Opublikowane w: Therapeutic Delivery, Numer 10/4, 2019, Strona(/y) 203-206, ISSN 2041-5990
Wydawca: Future Science
DOI: 10.4155/tde-2019-0009

Dry powder inhalation of siRNA

Autorzy: Tobias WM Keil, Olivia M Merkel
Opublikowane w: Therapeutic Delivery, Numer 10/5, 2019, Strona(/y) 265-267, ISSN 2041-5990
Wydawca: Future Science
DOI: 10.4155/tde-2019-0018

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