Biocompatible nanoparticles for T cell targeted siRNA delivery as novel asthma therapy

Characterization Techniques for Studying the Properties of Nanocarriers for Systemic Delivery

Autori: Aditi Mehta, Olivia M. Merkel
Pubblicato in: Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications, Numero 13, 2020, Pagina/e 57-86, ISBN 978-3-030-54489-8
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-54490-4_3

Evaluating the Regulation of Cytokine Levels After siRNA Treatment in Antigen-Specific Target Cell Populations via Intracellular Staining

Autori: Rima Kandil, Daniel Feldmann, Yuran Xie, Olivia M. Merkel
Pubblicato in: Handbook of Experimental Pharmacology, 2018, Pagina/e 323-331
Editore: Springer Berlin Heidelberg
DOI: 10.1007/978-1-4939-9092-4_21

A Method for Targeted Nonviral siRNA Delivery in Cancer and Inflammatory Diseases

Autori: Rima Kandil, Yuran Xie, Aditi Mehta, Olivia Merkel
Pubblicato in: Drug Delivery Systems, Numero 2059, 2020, Pagina/e 155-166, ISBN 978-1-4939-9797-8
Editore: Springer New York
DOI: 10.1007/978-1-4939-9798-5_7

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread

Autori: Shubhankar Ambike, Cho-Chin Cheng, Martin Feuerherd, Stoyan Velkov, Domizia Baldassi, Suliman Qadir Afridi, Diana Porras-Gonzalez, Xin Wei, Philipp Hagen, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Vincent Grass , Gerald Burgstaller, Andreas Pichlmair, Olivia M Merkel, Chunkyu Ko , Thomas Michler
Pubblicato in: Nucleic Acids Research, 2021, ISSN 1362-4962
Editore: oxford academics
DOI: 10.1093/nar/gkab1248

Intranasal drug delivery: opportunities and toxicologic challenges during drug development

Autori: Lea-Adriana Keller, Olivia Merkel , Andreas Popp
Pubblicato in: Drug Delivery and Translational Research, 2021, ISSN 2190-3948
Editore: springer international publication
DOI: 10.1007/s13346-020-00891-5

Air-liquid interface cultures of the healthy and diseased human respiratory tract: promises, challenges and future directions

Autori: Domizia Baldassi, Bettina Gabold , Olivia Merkel
Pubblicato in: Advanced Nanobiomed Research, 2021, ISSN 2699-9307
Editore: wiley
DOI: 10.1002/anbr.202000111

Impact of crystalline and amorphous matrices on successful spray drying of siRNA polyplexes for inhalation of nano-in-microparticles

Autori: Tobias Wm Keil, Christoph Zimmermann , Domizia Baldassi, Friederike Adams , Wolfgang Friess, Aditi Mehta, Olivia M Merkel
Pubblicato in: Advanced Therapeutics, 2021, ISSN 2366-3987
Editore: wiley
DOI: 10.1002/adtp.202100073

siRNA Therapeutics against Respiratory Viral Infections-What Have We Learned for Potential COVID-19 Therapies?

Autori: Aditi Mehta , Thomas Michler, Olivia M Merkel
Pubblicato in: Advanced Healthcare Materials, 2021, ISSN 2192-2659
Editore: World Scientific
DOI: 10.1002/adhm.202001650

The impact of microfluidic mixing of triblock micelleplexes on in vitro $/$ in vivo gene silencing and intracellular trafficking

Autori: Daniel P Feldmann, Yuran Xie, Steven K Jones, Dongyue Yu, Anna Moszczynska, Olivia M Merkel
Pubblicato in: Nanotechnology, Numero 28/22, 2017, Pagina/e 224001, ISSN 0957-4484
Editore: Institute of Physics Publishing
DOI: 10.1088/1361-6528/aa6d15

Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy

Autori: Elena Dalle Vedove, Gabriella Costabile, Olivia M. Merkel
Pubblicato in: Advanced Healthcare Materials, 2018, Pagina/e 1701398, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201701398

In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells

Autori: Daniel P. Feldmann, Yilong Cheng, Rima Kandil, Yuran Xie, Mariam Mohammadi, Hartmann Harz, Akhil Sharma, David J. Peeler, Anna Moszczynska, Heinrich Leonhardt, Suzie H. Pun, Olivia M. Merkel
Pubblicato in: Journal of Controlled Release, Numero 276, 2018, Pagina/e 50-58, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2018.02.017

Recent progress of polymeric nanogels for gene delivery

Autori: Rima Kandil, Olivia M. Merkel
Pubblicato in: Current Opinion in Colloid & Interface Science, Numero 39, 2019, Pagina/e 11-23, ISSN 1359-0294
Editore: Pergamon Press
DOI: 10.1016/j.cocis.2019.01.005

Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine

Autori: Yuran Xie, Bryan Killinger, Anna Moszczynska, Olivia Merkel
Pubblicato in: Molecules, Numero 21/10, 2016, Pagina/e 1334, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules21101334

Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma

Autori: Yuran Xie, Na Hyung Kim, Venkatareddy Nadithe, Dana Schalk, Archana Thakur, Ayşe Kılıç, Lawrence G. Lum, David J.P. Bassett, Olivia M. Merkel
Pubblicato in: Journal of Controlled Release, Numero 229, 2016, Pagina/e 120-129, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2016.03.029

Pulmonary Delivery of siRNA via Polymeric Vectors as Therapies of Asthma

Autori: Yuran Xie, Olivia M. Merkel
Pubblicato in: Archiv der Pharmazie, Numero 348/10, 2015, Pagina/e 681-688, ISSN 0365-6233
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ardp.201500120

Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution

Autori: Qian Zhong, Olivia M. Merkel, Joshua J. Reineke, Sandro R. P. da Rocha
Pubblicato in: Molecular Pharmaceutics, Numero 13/6, 2016, Pagina/e 1866-1878, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.6b00036

Immunogenicity of Cas9 Protein

Autori: Aditi Mehta, Olivia M. Merkel
Pubblicato in: Journal of Pharmaceutical Sciences, Numero 109/1, 2020, Pagina/e 62-67, ISSN 0022-3549
Editore: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2019.10.003

Nanoparticle-Mediated Gene Silencing for Sensitization of Lung Cancer to Cisplatin Therapy

Autori: Daniel P. Feldmann, Joshua Heyza, Christoph M. Zimmermann, Steve M. Patrick, Olivia M. Merkel
Pubblicato in: Molecules, Numero 25/8, 2020, Pagina/e 1994, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25081994

T-cell targeted pulmonary siRNA delivery for the treatment of asthma

Autori: Tobias W. M. Keil, Domizia Baldassi, Olivia M. Merkel
Pubblicato in: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2020, Pagina/e e1634, ISSN 1939-5116
Editore: wiley
DOI: 10.1002/wnan.1634

Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles

Autori: Tobias W.M. Keil, Daniel P. Feldmann, Gabriella Costabile, Qian Zhong, Sandro da Rocha, Olivia M. Merkel
Pubblicato in: European Journal of Pharmaceutics and Biopharmaceutics, Numero 143, 2019, Pagina/e 61-69, ISSN 0939-6411
Editore: Elsevier BV
DOI: 10.1016/j.ejpb.2019.08.012

Coming in and Finding Out: Blending Receptor‐Targeted Delivery and Efficient Endosomal Escape in a Novel Bio‐Responsive siRNA Delivery System for Gene Knockdown in Pulmonary T Cells

Autori: Rima Kandil, Yuran Xie, Ralf Heermann, Lorenz Isert, Kirsten Jung, Aditi Mehta, Olivia M. Merkel
Pubblicato in: Advanced Therapeutics, 2019, Pagina/e 1900047, ISSN 2366-3987
Editore: Weinh
DOI: 10.1002/adtp.201900047

Targeting KRAS Mutant Lung Cancer Cells with siRNA-Loaded Bovine Serum Albumin Nanoparticles

Autori: Aditi Mehta, Elena Dalle Vedove, Lorenz Isert, Olivia M. Merkel
Pubblicato in: Pharmaceutical Research, Numero 36/9, 2019, ISSN 0724-8741
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-019-2665-9

Characterization of positively charged polyplexes by tunable resistive pulse sensing

Autori: Tobias W.M. Keil, Olivia M. Merkel
Pubblicato in: European Journal of Pharmaceutics and Biopharmaceutics, Numero 158, 2021, Pagina/e 359-364, ISSN 0939-6411
Editore: Elsevier BV
DOI: 10.1016/j.ejpb.2020.12.010

Pulmonary delivery of siRNA as a novel treatment for lung diseases

Autori: Rima Kandil, Olivia M Merkel
Pubblicato in: Therapeutic Delivery, Numero 10/4, 2019, Pagina/e 203-206, ISSN 2041-5990
Editore: Future Science
DOI: 10.4155/tde-2019-0009

Dry powder inhalation of siRNA

Autori: Tobias WM Keil, Olivia M Merkel
Pubblicato in: Therapeutic Delivery, Numero 10/5, 2019, Pagina/e 265-267, ISSN 2041-5990
Editore: Future Science
DOI: 10.4155/tde-2019-0018

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