Intestinal Lipoidal Nanostructures - A Lipid Bridge to Increased Drug Delivery

Project Information

INTESTINANOS

Grant agreement ID: 638965

DOI

10.3030/638965

Project closed

EC signature date 17 August 2015

Start date 1 September 2015

End date 31 August 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 706 250,00

EU contribution

€ 1 706 250,00

Coordinated by

UPPSALA UNIVERSITET
Sweden

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (24)

Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization

Author(s): Albin Parrow, Per Larsson, Patrick Augustijns, Christel A. S. Bergström
Published in: Molecular Pharmaceutics, Issue 17/10, 2020, Page(s) 3837-3844, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.0c00588

Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach

Author(s): Per Larsson, Linda C. Alskär, Christel A. S. Bergström
Published in: Molecular Pharmaceutics, Issue 14/12, 2017, Page(s) 4145-4153, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.7b00397

Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations

Author(s): Janneke Keemink, Christel A. S. Bergström
Published in: Pharmaceutical Research, Issue 35/4, 2018, ISSN 0724-8741
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-017-2327-8

Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid

Author(s): Andrew J. Clulow, Albin Parrow, Adrian Hawley, Jamal Khan, Anna C. Pham, Per Larsson, Christel A. S. Bergström, Ben J. Boyd
Published in: The Journal of Physical Chemistry B, Issue 121/48, 2017, Page(s) 10869-10881, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.7b08622

Computational prediction of drug solubility in water-based systems: Qualitative and quantitative approaches used in the current drug discovery and development setting

Author(s): Christel A.S. Bergström, Per Larsson
Published in: International Journal of Pharmaceutics, Issue 540/1-2, 2018, Page(s) 185-193, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2018.01.044

Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations

Author(s): Linda C. Alskär, Janneke Keemink, Jenny Johannesson, Christopher J. H. Porter, Christel A. S. Bergström
Published in: Molecular Pharmaceutics, Issue 15/10, 2018, Page(s) 4733-4744, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.8b00699

Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

Author(s): Amjad Alhalaweh, Ahmad Alzghoul, Denny Mahlin, Christel A.S. Bergström
Published in: International Journal of Pharmaceutics, Issue 495/1, 2015, Page(s) 312-317, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2015.08.101

The Need for Restructuring the Disordered Science of Amorphous Drug Formulations

Author(s): Khadijah Edueng, Denny Mahlin, Christel A. S. Bergström
Published in: Pharmaceutical Research, Issue 34/9, 2017, Page(s) 1754-1772, ISSN 0724-8741
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-017-2174-7

Tools for Early Prediction of Drug Loading in Lipid-Based Formulations

Author(s): Linda C. Alskär, Christopher J. H. Porter, Christel A. S. Bergström
Published in: Molecular Pharmaceutics, Issue 13/1, 2016, Page(s) 251-261, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.5b00704

Computational modeling to predict the functions and impact of drug transporters

Author(s): Pär Matsson, Christel A S Bergström
Published in: In Silico Pharmacology, Issue 3/1, 2015, ISSN 2193-9616
Publisher: Springer Open
DOI: 10.1186/s40203-015-0012-3

Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations

Author(s): Michael Holmboe, Per Larsson, Jamshed Anwar, Christel A. S. Bergström
Published in: Langmuir, Issue 32/48, 2016, Page(s) 12732-12740, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.6b03008

Models for Predicting Drug Absorption From Oral Lipid-Based Formulations

Author(s): Linda C. Alskär, Christel A. S. Bergström
Published in: Current Molecular Biology Reports, Issue 1/4, 2015, Page(s) 141-147, ISSN 2198-6428
Publisher: Springer International Publishing
DOI: 10.1007/s40610-015-0023-1

Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways

Author(s): Khadijah Edueng, Denny Mahlin, Per Larsson, Christel A.S. Bergström
Published in: Journal of Controlled Release, Issue 256, 2017, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2017.04.015

Computational prediction of formulation strategies for beyond-rule-of-5 compounds

Author(s): Christel A.S. Bergström, William N. Charman, Christopher J.H. Porter
Published in: Advanced Drug Delivery Reviews, Issue 101, 2016, Page(s) 6-21, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2016.02.005

Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage

Author(s): Khadijah Edueng, Denny Mahlin, Johan Gråsjö, Olivia Nylander, Manish Thakrani, Christel A.S. Bergström
Published in: Molecules, Issue 24/15, 2019, Page(s) 2731, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24152731

Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro

Author(s): Janneke Keemink, Elin Mårtensson, Christel A.S. Bergström
Published in: Molecular Pharmaceutics, Issue 16/3, 2019, Page(s) 921-930, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.8b00811

Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics Simulation

Author(s): Md Shakhawath Hossain, Staffan Berg, Christel A. S. Bergström, Per Larsson
Published in: AAPS PharmSciTech, Issue 20/2, 2019, ISSN 1530-9932
Publisher: American Association of Pharmaceutical Scientists
DOI: 10.1208/s12249-018-1289-4

An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

Author(s): Caroline Alvebratt, Janneke Keemink, Khadijah Edueng, Ocean Cheung, Maria Strømme, Christel A.S. Bergström
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 149, 2020, Page(s) 21-29, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2020.01.010

Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?

Author(s): Linda C. Alskär, Albin Parrow, Janneke Keemink, Pernilla Johansson, Bertil Abrahamsson, Christel A.S. Bergström
Published in: Journal of Controlled Release, Issue 304, 2019, Page(s) 90-100, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2019.04.038

Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning

Author(s): Shakhawath Hossain, Aleksei Kabedev, Albin Parrow, Christel A.S. Bergström, Per Larsson
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 137, 2019, Page(s) 46-55, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2019.02.007

Long-Term Physical (In)Stability of Spray-Dried Amorphous Drugs: Relationship with Glass-Forming Ability and Physicochemical Properties

Author(s): Edueng, Bergström, Gråsjö, Mahlin
Published in: Pharmaceutics, Issue 11/9, 2019, Page(s) 425, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics11090425

Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations

Author(s): Oliver J. Hedge, Christel A. S. Bergström
Published in: Pharmaceutical Research, Issue 37/6, 2020, ISSN 0724-8741
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-020-02833-9

Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers.

Author(s): Shakhawath Hossain, Paul Joyce, Albin Parrow, S Jõemetsa, Fredrik Höök, Per Larsson, Christel Bergström
Published in: Molecular Pharmaceutics, 2020, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.0c00668

Investigating drug permeation across a lipid membrane supported on mesoporous silica

Author(s): Paul Joyce, Silver Jõemetsa, Simon Isaksson, Shakhawath Hossain, Per Larsson, Christel Bergström, Fredrik Höök
Published in: Angewandte Chemie International Edition, 2020, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202011931