Intestinal Lipoidal Nanostructures - A Lipid Bridge to Increased Drug Delivery

Información del proyecto

INTESTINANOS

Identificador del acuerdo de subvención: 638965

DOI

10.3030/638965

Proyecto cerrado

Fecha de la firma de la CE 17 Agosto 2015

Fecha de inicio 1 Septiembre 2015

Fecha de finalización 31 Agosto 2020

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 706 250,00

Aportación de la UE

€ 1 706 250,00

Coordinado por

UPPSALA UNIVERSITET
Sweden

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (24)

Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization

Autores: Albin Parrow, Per Larsson, Patrick Augustijns, Christel A. S. Bergström
Publicado en: Molecular Pharmaceutics, Edición 17/10, 2020, Página(s) 3837-3844, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.0c00588

Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach

Autores: Per Larsson, Linda C. Alskär, Christel A. S. Bergström
Publicado en: Molecular Pharmaceutics, Edición 14/12, 2017, Página(s) 4145-4153, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.7b00397

Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations

Autores: Janneke Keemink, Christel A. S. Bergström
Publicado en: Pharmaceutical Research, Edición 35/4, 2018, ISSN 0724-8741
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-017-2327-8

Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid

Autores: Andrew J. Clulow, Albin Parrow, Adrian Hawley, Jamal Khan, Anna C. Pham, Per Larsson, Christel A. S. Bergström, Ben J. Boyd
Publicado en: The Journal of Physical Chemistry B, Edición 121/48, 2017, Página(s) 10869-10881, ISSN 1520-6106
Editor: American Chemical Society
DOI: 10.1021/acs.jpcb.7b08622

Computational prediction of drug solubility in water-based systems: Qualitative and quantitative approaches used in the current drug discovery and development setting

Autores: Christel A.S. Bergström, Per Larsson
Publicado en: International Journal of Pharmaceutics, Edición 540/1-2, 2018, Página(s) 185-193, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2018.01.044

Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations

Autores: Linda C. Alskär, Janneke Keemink, Jenny Johannesson, Christopher J. H. Porter, Christel A. S. Bergström
Publicado en: Molecular Pharmaceutics, Edición 15/10, 2018, Página(s) 4733-4744, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.8b00699

Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

Autores: Amjad Alhalaweh, Ahmad Alzghoul, Denny Mahlin, Christel A.S. Bergström
Publicado en: International Journal of Pharmaceutics, Edición 495/1, 2015, Página(s) 312-317, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2015.08.101

The Need for Restructuring the Disordered Science of Amorphous Drug Formulations

Autores: Khadijah Edueng, Denny Mahlin, Christel A. S. Bergström
Publicado en: Pharmaceutical Research, Edición 34/9, 2017, Página(s) 1754-1772, ISSN 0724-8741
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-017-2174-7

Tools for Early Prediction of Drug Loading in Lipid-Based Formulations

Autores: Linda C. Alskär, Christopher J. H. Porter, Christel A. S. Bergström
Publicado en: Molecular Pharmaceutics, Edición 13/1, 2016, Página(s) 251-261, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.5b00704

Computational modeling to predict the functions and impact of drug transporters

Autores: Pär Matsson, Christel A S Bergström
Publicado en: In Silico Pharmacology, Edición 3/1, 2015, ISSN 2193-9616
Editor: Springer Open
DOI: 10.1186/s40203-015-0012-3

Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations

Autores: Michael Holmboe, Per Larsson, Jamshed Anwar, Christel A. S. Bergström
Publicado en: Langmuir, Edición 32/48, 2016, Página(s) 12732-12740, ISSN 0743-7463
Editor: American Chemical Society
DOI: 10.1021/acs.langmuir.6b03008

Models for Predicting Drug Absorption From Oral Lipid-Based Formulations

Autores: Linda C. Alskär, Christel A. S. Bergström
Publicado en: Current Molecular Biology Reports, Edición 1/4, 2015, Página(s) 141-147, ISSN 2198-6428
Editor: Springer International Publishing
DOI: 10.1007/s40610-015-0023-1

Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways

Autores: Khadijah Edueng, Denny Mahlin, Per Larsson, Christel A.S. Bergström
Publicado en: Journal of Controlled Release, Edición 256, 2017, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2017.04.015

Computational prediction of formulation strategies for beyond-rule-of-5 compounds

Autores: Christel A.S. Bergström, William N. Charman, Christopher J.H. Porter
Publicado en: Advanced Drug Delivery Reviews, Edición 101, 2016, Página(s) 6-21, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2016.02.005

Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage

Autores: Khadijah Edueng, Denny Mahlin, Johan Gråsjö, Olivia Nylander, Manish Thakrani, Christel A.S. Bergström
Publicado en: Molecules, Edición 24/15, 2019, Página(s) 2731, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24152731

Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro

Autores: Janneke Keemink, Elin Mårtensson, Christel A.S. Bergström
Publicado en: Molecular Pharmaceutics, Edición 16/3, 2019, Página(s) 921-930, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.8b00811

Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics Simulation

Autores: Md Shakhawath Hossain, Staffan Berg, Christel A. S. Bergström, Per Larsson
Publicado en: AAPS PharmSciTech, Edición 20/2, 2019, ISSN 1530-9932
Editor: American Association of Pharmaceutical Scientists
DOI: 10.1208/s12249-018-1289-4

An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

Autores: Caroline Alvebratt, Janneke Keemink, Khadijah Edueng, Ocean Cheung, Maria Strømme, Christel A.S. Bergström
Publicado en: European Journal of Pharmaceutics and Biopharmaceutics, Edición 149, 2020, Página(s) 21-29, ISSN 0939-6411
Editor: Elsevier BV
DOI: 10.1016/j.ejpb.2020.01.010

Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?

Autores: Linda C. Alskär, Albin Parrow, Janneke Keemink, Pernilla Johansson, Bertil Abrahamsson, Christel A.S. Bergström
Publicado en: Journal of Controlled Release, Edición 304, 2019, Página(s) 90-100, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2019.04.038

Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning

Autores: Shakhawath Hossain, Aleksei Kabedev, Albin Parrow, Christel A.S. Bergström, Per Larsson
Publicado en: European Journal of Pharmaceutics and Biopharmaceutics, Edición 137, 2019, Página(s) 46-55, ISSN 0939-6411
Editor: Elsevier BV
DOI: 10.1016/j.ejpb.2019.02.007

Long-Term Physical (In)Stability of Spray-Dried Amorphous Drugs: Relationship with Glass-Forming Ability and Physicochemical Properties

Autores: Edueng, Bergström, Gråsjö, Mahlin
Publicado en: Pharmaceutics, Edición 11/9, 2019, Página(s) 425, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics11090425

Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations

Autores: Oliver J. Hedge, Christel A. S. Bergström
Publicado en: Pharmaceutical Research, Edición 37/6, 2020, ISSN 0724-8741
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-020-02833-9

Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers.

Autores: Shakhawath Hossain, Paul Joyce, Albin Parrow, S Jõemetsa, Fredrik Höök, Per Larsson, Christel Bergström
Publicado en: Molecular Pharmaceutics, 2020, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.0c00668

Investigating drug permeation across a lipid membrane supported on mesoporous silica

Autores: Paul Joyce, Silver Jõemetsa, Simon Isaksson, Shakhawath Hossain, Per Larsson, Christel Bergström, Fredrik Höök
Publicado en: Angewandte Chemie International Edition, 2020, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202011931