Intestinal Lipoidal Nanostructures - A Lipid Bridge to Increased Drug Delivery

Informazioni relative al progetto

INTESTINANOS

ID dell’accordo di sovvenzione: 638965

DOI

10.3030/638965

Progetto chiuso

Data della firma CE 17 Agosto 2015

Data di avvio 1 Settembre 2015

Data di completamento 31 Agosto 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 706 250,00

Contributo UE

€ 1 706 250,00

Coordinato da

UPPSALA UNIVERSITET
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (24)

Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization

Autori: Albin Parrow, Per Larsson, Patrick Augustijns, Christel A. S. Bergström
Pubblicato in: Molecular Pharmaceutics, Numero 17/10, 2020, Pagina/e 3837-3844, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.0c00588

Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach

Autori: Per Larsson, Linda C. Alskär, Christel A. S. Bergström
Pubblicato in: Molecular Pharmaceutics, Numero 14/12, 2017, Pagina/e 4145-4153, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.7b00397

Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations

Autori: Janneke Keemink, Christel A. S. Bergström
Pubblicato in: Pharmaceutical Research, Numero 35/4, 2018, ISSN 0724-8741
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-017-2327-8

Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid

Autori: Andrew J. Clulow, Albin Parrow, Adrian Hawley, Jamal Khan, Anna C. Pham, Per Larsson, Christel A. S. Bergström, Ben J. Boyd
Pubblicato in: The Journal of Physical Chemistry B, Numero 121/48, 2017, Pagina/e 10869-10881, ISSN 1520-6106
Editore: American Chemical Society
DOI: 10.1021/acs.jpcb.7b08622

Computational prediction of drug solubility in water-based systems: Qualitative and quantitative approaches used in the current drug discovery and development setting

Autori: Christel A.S. Bergström, Per Larsson
Pubblicato in: International Journal of Pharmaceutics, Numero 540/1-2, 2018, Pagina/e 185-193, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2018.01.044

Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations

Autori: Linda C. Alskär, Janneke Keemink, Jenny Johannesson, Christopher J. H. Porter, Christel A. S. Bergström
Pubblicato in: Molecular Pharmaceutics, Numero 15/10, 2018, Pagina/e 4733-4744, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.8b00699

Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

Autori: Amjad Alhalaweh, Ahmad Alzghoul, Denny Mahlin, Christel A.S. Bergström
Pubblicato in: International Journal of Pharmaceutics, Numero 495/1, 2015, Pagina/e 312-317, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2015.08.101

The Need for Restructuring the Disordered Science of Amorphous Drug Formulations

Autori: Khadijah Edueng, Denny Mahlin, Christel A. S. Bergström
Pubblicato in: Pharmaceutical Research, Numero 34/9, 2017, Pagina/e 1754-1772, ISSN 0724-8741
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-017-2174-7

Tools for Early Prediction of Drug Loading in Lipid-Based Formulations

Autori: Linda C. Alskär, Christopher J. H. Porter, Christel A. S. Bergström
Pubblicato in: Molecular Pharmaceutics, Numero 13/1, 2016, Pagina/e 251-261, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.5b00704

Computational modeling to predict the functions and impact of drug transporters

Autori: Pär Matsson, Christel A S Bergström
Pubblicato in: In Silico Pharmacology, Numero 3/1, 2015, ISSN 2193-9616
Editore: Springer Open
DOI: 10.1186/s40203-015-0012-3

Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations

Autori: Michael Holmboe, Per Larsson, Jamshed Anwar, Christel A. S. Bergström
Pubblicato in: Langmuir, Numero 32/48, 2016, Pagina/e 12732-12740, ISSN 0743-7463
Editore: American Chemical Society
DOI: 10.1021/acs.langmuir.6b03008

Models for Predicting Drug Absorption From Oral Lipid-Based Formulations

Autori: Linda C. Alskär, Christel A. S. Bergström
Pubblicato in: Current Molecular Biology Reports, Numero 1/4, 2015, Pagina/e 141-147, ISSN 2198-6428
Editore: Springer International Publishing
DOI: 10.1007/s40610-015-0023-1

Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways

Autori: Khadijah Edueng, Denny Mahlin, Per Larsson, Christel A.S. Bergström
Pubblicato in: Journal of Controlled Release, Numero 256, 2017, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2017.04.015

Computational prediction of formulation strategies for beyond-rule-of-5 compounds

Autori: Christel A.S. Bergström, William N. Charman, Christopher J.H. Porter
Pubblicato in: Advanced Drug Delivery Reviews, Numero 101, 2016, Pagina/e 6-21, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2016.02.005

Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage

Autori: Khadijah Edueng, Denny Mahlin, Johan Gråsjö, Olivia Nylander, Manish Thakrani, Christel A.S. Bergström
Pubblicato in: Molecules, Numero 24/15, 2019, Pagina/e 2731, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24152731

Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro

Autori: Janneke Keemink, Elin Mårtensson, Christel A.S. Bergström
Pubblicato in: Molecular Pharmaceutics, Numero 16/3, 2019, Pagina/e 921-930, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.8b00811

Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics Simulation

Autori: Md Shakhawath Hossain, Staffan Berg, Christel A. S. Bergström, Per Larsson
Pubblicato in: AAPS PharmSciTech, Numero 20/2, 2019, ISSN 1530-9932
Editore: American Association of Pharmaceutical Scientists
DOI: 10.1208/s12249-018-1289-4

An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

Autori: Caroline Alvebratt, Janneke Keemink, Khadijah Edueng, Ocean Cheung, Maria Strømme, Christel A.S. Bergström
Pubblicato in: European Journal of Pharmaceutics and Biopharmaceutics, Numero 149, 2020, Pagina/e 21-29, ISSN 0939-6411
Editore: Elsevier BV
DOI: 10.1016/j.ejpb.2020.01.010

Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?

Autori: Linda C. Alskär, Albin Parrow, Janneke Keemink, Pernilla Johansson, Bertil Abrahamsson, Christel A.S. Bergström
Pubblicato in: Journal of Controlled Release, Numero 304, 2019, Pagina/e 90-100, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2019.04.038

Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning

Autori: Shakhawath Hossain, Aleksei Kabedev, Albin Parrow, Christel A.S. Bergström, Per Larsson
Pubblicato in: European Journal of Pharmaceutics and Biopharmaceutics, Numero 137, 2019, Pagina/e 46-55, ISSN 0939-6411
Editore: Elsevier BV
DOI: 10.1016/j.ejpb.2019.02.007

Long-Term Physical (In)Stability of Spray-Dried Amorphous Drugs: Relationship with Glass-Forming Ability and Physicochemical Properties

Autori: Edueng, Bergström, Gråsjö, Mahlin
Pubblicato in: Pharmaceutics, Numero 11/9, 2019, Pagina/e 425, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics11090425

Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations

Autori: Oliver J. Hedge, Christel A. S. Bergström
Pubblicato in: Pharmaceutical Research, Numero 37/6, 2020, ISSN 0724-8741
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-020-02833-9

Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers.

Autori: Shakhawath Hossain, Paul Joyce, Albin Parrow, S Jõemetsa, Fredrik Höök, Per Larsson, Christel Bergström
Pubblicato in: Molecular Pharmaceutics, 2020, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.0c00668

Investigating drug permeation across a lipid membrane supported on mesoporous silica

Autori: Paul Joyce, Silver Jõemetsa, Simon Isaksson, Shakhawath Hossain, Per Larsson, Christel Bergström, Fredrik Höök
Pubblicato in: Angewandte Chemie International Edition, 2020, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202011931