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Towards a Self-Amplifying Carbon-Fixing Anabolic Cycle

Obiettivo

How can simple molecules self-organize into a growing synthetic reaction network like biochemical metabolism? This proposal takes a novel synthesis-driven approach to the question by mimicking a central self-amplifying CO2-fixing biochemical reaction cycle known as the reductive tricarboxylic acid cycle. The intermediates of this cycle are the synthetic precursors to all major classes of biomolecules and are built from CO2, an anhydride and electrons from simple reducing agents. Based on the nature of the reactions in the cycle and the specific structural features of the intermediates that comprise it, we propose that the entire cycle may be enabled in a single reaction vessel with a surprisingly small number of simple, mutually compatible catalysts from the recent synthetic organic literature. However, since one of the required reactions does not yet have an efficient synthetic equivalent in the literature and since those that do have not yet been carried out sequentially in a single reaction vessel, we will first independently develop the new reaction and sequences before attempting to combine them into the entire cycle. The new reaction and sequences will be useful green synthetic methods in their own right. Most significantly, this endeavour could provide the first experimental evidence of an exciting new alternative model for early biochemical evolution that finally illuminates the origins and necessity of biochemistry’s core reactions.

Meccanismo di finanziamento

ERC-STG - Starting Grant

Istituzione ospitante

CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION
Contribution nette de l'UE
€ 1 500 000,00
Indirizzo
Allee G Monge 8
67000 Strasbourg
Francia
Tipo di attività
Research Organisations
Contributo di paesi terzi
€ 0,00

Beneficiari (2)

CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION
Francia
Contribution nette de l'UE
€ 1 500 000,00
Indirizzo
Allee G Monge 8
67000 Strasbourg
Tipo di attività
Research Organisations
Contributo di paesi terzi
€ 0,00
Terza parte

Soggetto giuridico diverso da un subappaltatore che è affiliato o legalmente collegato a un partecipante. Il soggetto svolge le attività secondo le condizioni stabilite nell’accordo di sovvenzione, fornisce beni o servizi per l’azione, ma non ha sottoscritto l’accordo di sovvenzione. Una terza parte rispetta le regole applicabili al suo partecipante correlato ai sensi dell’accordo di sovvenzione per quanto riguarda l’ammissibilità dei costi e il controllo delle spese.

UNIVERSITE DE STRASBOURG
Francia
Contribution nette de l'UE
€ 0,00
Indirizzo
Rue Blaise Pascal 4
67081 Strasbourg
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00