How complement molecules kill bacteria

Informazioni relative al progetto

ComBact

ID dell’accordo di sovvenzione: 639209

DOI

10.3030/639209

Progetto chiuso

Data della firma CE 13 Febbraio 2015

Data di avvio 1 Marzo 2015

Data di completamento 29 Febbraio 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 497 290,00

Contributo UE

€ 1 497 290,00

Coordinato da

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (14)

Novel Evasion Mechanisms of the Classical Complement Pathway

Autori: Brandon L. Garcia, Seline A. Zwarthoff, Suzan H. M. Rooijakkers, Brian V. Geisbrecht
Pubblicato in: The Journal of Immunology, Numero 197/6, 2016, Pagina/e 2051-2060, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1600863

Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface

Autori: Elise S. Hovingh, Bryan van den Broek, Betsy Kuipers, Elena Pinelli, Suzan H. M. Rooijakkers, Ilse Jongerius
Pubblicato in: PLOS Pathogens, Numero 13/7, 2017, Pagina/e e1006531, ISSN 1553-7374
Editore: plos pathogens
DOI: 10.1371/journal.ppat.1006531

Evidence for Multiple Modes of Neutrophil Serine Protease Recognition by the EAP Family of Staphylococcal Innate Immune Evasion Proteins

Autori: Daphne A.C. Stapels, Jordan L. Woehl, Fin J. Milder, Angelino T. Tromp, Aernoud A. van Batenburg, Wilco C. de Graaf, Samuel C. Broll, Natalie M. White, Suzan H.M. Rooijakkers, Brian V. Geisbrecht
Pubblicato in: Protein Science, 2017, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.3342

Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes

Autori: Evelien T. M. Berends, Ronald D. Gorham, Maartje Ruyken, Jasper A. Soppe, Hatice Orhan, Piet C. Aerts, Carla J. C. de Haas, Piet Gros, Suzan H. M. Rooijakkers
Pubblicato in: BMC Biology, Numero 13/1, 2015, ISSN 1741-7007
Editore: BioMed Central
DOI: 10.1186/s12915-015-0203-8

The Staphylococcus aureus polysaccharide capsule and Efb-dependent fibrinogen shield act in concert to protect against phagocytosis

Autori: Annemarie Kuipers, Daphne A. C. Stapels, Maartje Ruyken, Lleroy T. Weerwind, Suzan H. M. Rooijakkers, Jean C. Lee, Kok P. M. van Kessel, Ya-Ping Ko
Pubblicato in: Microbiology, Numero 162/7, 2016, Pagina/e 1185-1194, ISSN 1350-0872
Editore: Society for General Microbiology
DOI: 10.1099/mic.0.000293

Complement resistance mechanisms of Klebsiella pneumoniae

Autori: Dennis J. Doorduijn, Suzan H.M. Rooijakkers, Willem van Schaik, Bart W. Bardoel
Pubblicato in: Immunobiology, Numero 221/10, 2016, Pagina/e 1102-1109, ISSN 0171-2985
Editore: Elsevier BV
DOI: 10.1016/j.imbio.2016.06.014

How the Membrane Attack Complex Damages the Bacterial Cell Envelope and Kills Gram‐Negative Bacteria

Autori: Dennis J. Doorduijn, Suzan H. M. Rooijakkers, Dani A. C. Heesterbeek
Pubblicato in: BioEssays, Numero 41/10, 2019, Pagina/e 1900074, ISSN 0265-9247
Editore: John Wiley & Sons Inc.
DOI: 10.1002/bies.201900074

Bacterial killing by complement requires membrane attack complex formation via surface-bound C5 convertases

Autori: Heesterbeek, D. A.; Bardoel, B. W.; Parsons, E. S.; Bennett, I.; Ruyken, M.; Doorduijn, D. J.; Gorham, R. D.; Berends, E. T.; Pyne, A. L.; Hoogenboom, B. W.; Rooijakkers, S. H.
Pubblicato in: EMBO Journal , Article e99852. (2019) (In press)., Numero 1, 2019, ISSN 1460-2075
Editore: EMBOpress
DOI: 10.15252/embj.201899852

Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models

Autori: Seline A. Zwarthoff, Evelien T. M. Berends, Sanne Mol, Maartje Ruyken, Piet C. Aerts, Mihály Józsi, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Ronald D. Gorham
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2018.01691

Group IIA-Secreted Phospholipase A 2 in Human Serum Kills Commensal but Not Clinical Enterococcus faecium Isolates

Autori: Fernanda L. Paganelli, Helen L. Leavis, Samantha He, Nina M. van Sorge, Christine Payré, Gérard Lambeau, Rob J. L. Willems, Suzan H. M. Rooijakkers
Pubblicato in: Infection and Immunity, Numero 86/8, 2018, ISSN 0019-9567
Editore: American Society for Microbiology
DOI: 10.1128/iai.00180-18

Identification of a staphylococcal complement inhibitor with broad host specificity in equid Staphylococcus aureus strains

Autori: Nienke W. M. de Jong, Manouk Vrieling, Brandon L. Garcia, Gerrit Koop, Matt Brettmann, Piet C. Aerts, Maartje Ruyken, Jos A. G. van Strijp, Mark Holmes, Ewan M. Harrison, Brian V. Geisbrecht, Suzan H. M. Rooijakkers
Pubblicato in: Journal of Biological Chemistry, Numero 293/12, 2018, Pagina/e 4468-4477, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA117.000599

Complement and Bacterial Infections: From Molecular Mechanisms to Therapeutic Applications

Autori: Dani A.C. Heesterbeek, Mathieu L. Angelier, Richard A. Harrison, Suzan H.M. Rooijakkers
Pubblicato in: Journal of Innate Immunity, Numero 10/5-6, 2018, Pagina/e 455-464, ISSN 1662-811X
Editore: Karger AG
DOI: 10.1159/000491439

Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics

Autori: D. A. C. Heesterbeek, N. I. Martin, A. Velthuizen, M. Duijst, M. Ruyken, R. Wubbolts, S. H. M. Rooijakkers, B. W. Bardoel
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-38577-9

Let’s Tie the Knot: Marriage of Complement and Adaptive Immunity in Pathogen Evasion, for Better or Worse

Autori: Kaila M. Bennett, Suzan H. M. Rooijakkers, Ronald D. Gorham
Pubblicato in: Frontiers in Microbiology, Numero 8, 2017, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2017.00089

Other (3)

Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes

Autori: Dani A. C. Heesterbeek, Remy M. Muts, Vincent P. van Hensbergen, Pieter de Saint Aulaire, Tom Wennekes, Bart W. Bardoel, Nina M. van Sorge, Suzan H.M. Rooijakkers
Pubblicato in: Review Commons, 2020
Editore: Review Commons
DOI: 10.1101/2020.01.28.923243

Bacterial killing by complement requires direct anchoring of Membrane Attack Complex precursor C5b-7

Autori: Dennis J Doorduijn, Bart W Bardoel, Dani AC Heesterbeek, Maartje Ruyken, Georgina Benn, Edward S Parsons, Bart Hoogenboom, Suzan HM Rooijakkers
Pubblicato in: Review Commons, 2019
Editore: Review Commons
DOI: 10.1101/2019.12.17.877639

In vitro evolution of colistin resistance in the Klebsiella pneumoniae complex follows multiple evolutionary trajectories with variable effects on fitness and virulence characteristics

Autori: Axel B. Janssen, Dennis J. Doorduijn, Grant Mills, Malbert R.C. Rogers, Marc J.M. Bonten, Suzan H.M. Rooijakkers, Rob J.L. Willems, Jose A. Bengoechea, Willem van Schaik
Pubblicato in: biorxiv, 2020
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.05.24.112334