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Dynamic interplay between DNA methylation, histone modifications and super enhancer activity in normal T cells and during malignant T cell transformation

Pubblicazioni

Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development

Autori: Juliette Roels, Anna Kuchmiy, Matthias De Decker, Steven Strubbe, Marieke Lavaert, Kai Ling Liang, Georges Leclercq, Bart Vandekerckhove, Filip Van Nieuwerburgh, Pieter Van Vlierberghe, Tom Taghon
Pubblicato in: Nature Immunology, 2020, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-020-0747-9

SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival

Autori: Hexiu Su, Juncheng Hu, Liang Huang, Yang Yang, Morgan Thenoz, Anna Kuchmiy, Yufeng Hu, Peng Li, Hui Feng, Yu Zhou, Tom Taghon, Pieter Van Vlierberghe, Guoliang Qing, Zhichao Chen, Hudan Liu
Pubblicato in: Nature Communications, 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-06523-4

Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia

Autori: Andreas Kloetgen, Palaniraja Thandapani, Panagiotis Ntziachristos, Yohana Ghebrechristos, Sofia Nomikou, Charalampos Lazaris, Xufeng Chen, Hai Hu, Sofia Bakogianni, Jingjing Wang, Yi Fu, Francesco Boccalatte, Hua Zhong, Elisabeth Paietta, Thomas Trimarchi, Yixing Zhu, Pieter Van Vlierberghe, Giorgio G. Inghirami, Timothee Lionnet, Iannis Aifantis, Aristotelis Tsirigos
Pubblicato in: Nature Genetics, 52/4, 2020, Page(s) 388-400, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-020-0602-9

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

Autori: Renate De Smedt, Julie Morscio, Lindy Reunes, Juliette Roels, Valentina Bardelli, Beatrice Lintermans, Wouter Van Loocke, Afonso Almeida, Laurence C. Cheung, Rishi S. Kotecha, Marc R. Mansour, Anne Uyttebroeck, Peter Vandenberghe, Roberta La Starza, Cristina Mecucci, Tim Lammens, Nadine Van Roy, Barbara De Moerloose, João T. Barata, Tom Taghon, Steven Goossens, Pieter Van Vlierberghe
Pubblicato in: Blood, 135/19, 2020, Page(s) 1685-1695, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2019003880

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes

Autori: Marieke Lavaert, Kai Ling Liang, Niels Vandamme, Jong-Eun Park, Juliette Roels, Monica S. Kowalczyk, Bo Li, Orr Ashenberg, Marcin Tabaka, Danielle Dionne, Timothy L. Tickle, Michal Slyper, Orit Rozenblatt-Rosen, Bart Vandekerckhove, Georges Leclercq, Aviv Regev, Pieter Van Vlierberghe, Martin Guilliams, Sarah A. Teichmann, Yvan Saeys, Tom Taghon
Pubblicato in: Immunity, 52/6, 2020, Page(s) 1088-1104.e6, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2020.03.019

Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia

Autori: Yalu Zhou, Cuijuan Han, Eric Wang, Adam H. Lorch, Valentina Serafin, Byoung-Kyu Cho, Blanca T. Guttierrez Diaz, Julien Calvo, Celestia Fang, Alireza Khodadadi-Jamayran, Tommaso Tabaglio, Christian Marier, Anna Kuchmiy, Limin Sun, George Yacu, Szymon K. Filip, Qi Jin, Yoh-hei Takahashi, David R. Amici, Emily J. Rendleman, Radhika Rawat, Silvia Bresolin, Maddalena Paganin, Cheng Zhang, Hu Li, Irawat
Pubblicato in: Cancer Discovery, 2020, Page(s) CD-19-1436, ISSN 2159-8274
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-19-1436

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Autori: Juliette Roels, Morgan Thenoz, Bronisława Szarzynska, Mattias Landfors, Stien De Coninck, Lisa Demoen, Lien Provez, Anna Kuchmiy, Steven Strubbe, Lindy Reunes, Tim Pieters, Filip Matthijssens, Wouter Van Loocke, Busra Erarslan Uysal, Paulina Richter Pechańska, Ken Declerck, Tim Lammens, Barbara De Moerloose, Dieter Deforce, Filip Van Nieuwerburgh, Laurence Cheung, Rishi Kotecha, Marc Mansour, B
Pubblicato in: Blood Cancer Discovery, 2020, ISSN 2643-3249
Editore: AACR