ONCOgenic Receptor Network of Excellence and Training

Información del proyecto

ONCORNET

Identificador del acuerdo de subvención: 641833

DOI

10.3030/641833

Proyecto cerrado

Fecha de la firma de la CE 16 Diciembre 2014

Fecha de inicio 1 Enero 2015

Fecha de finalización 31 Mayo 2019

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 893 983,37

Aportación de la UE

€ 3 893 983,37

Coordinado por

STICHTING VU
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (4)

Draft Periodic Report

Compulsory deliverable

Mid-Term Review meeting

Compulsory deliverable

Progress Report

Compulsory deliverable

Ethics

Compulsory deliverable

Websites, patent fillings, videos etc. (2)

ONCORNET website

ONCORNET website built and online wwwoncorneteu 2

Output

Abstracts for international conferences and publications submitted

Other (2)

Open meetings organized

Kick-off organised in conjunction with AIMMS-GPCR symposium (7) Final meeting organised

Supervisory board of Network

Compulsory deliverable

Publicaciones

Book chapters (3)

Molecular Pharmacology of Chemokine Receptors

Autores: Raymond H. de Wit, Sabrina M. de Munnik, Rob Leurs, Henry F. Vischer and Martine J. Smit
Publicado en: Methods in Enzymology, editor: Tracy M. Handel, Edición 570, 2016, Página(s) 457-515, ISBN 978-0-12-802171-2
Editor: Academic Press
DOI: 10.1016/bs.mie.2015.12.002

Time-Resolved FRET-Based Assays to Characterize G Protein-Coupled Receptor Hetero-oligomer Pharmacology

Autores: Joyce Heuninck, Candide Hounsou, Elodie Dupuis, Eric Trinquet, Bernard Mouillac, Jean-Philippe Pin, Dominique Bonnet, Thierry Durroux
Publicado en: G Protein-Coupled Receptor Signaling - Methods and Protocols, Edición 1947, 2019, Página(s) 151-168, ISBN 978-1-4939-9120-4
Editor: Springer New York
DOI: 10.1007/978-1-4939-9121-1_8

Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding

Autores: Orestis Faklaris, Joyce Heuninck, Amandine Falco, Elise Goyet, Jurriaan M. Zwier, Jean-Philippe Pin, Bernard Mouillac, Julie Perroy, Thierry Durroux
Publicado en: Topics in Medicinal Chemistry, 2017
Editor: Springer Berlin Heidelberg
DOI: 10.1007/7355_2017_2

Peer reviewed articles (15)

Atypical chemokine receptor 3 (ACKR3): a comprehensive overview of its expression and potential roles in the immune system.

Autores: Joyce Koenen, Francoise Bachelerie, Karl Balabanian, Geraldine Schlecht-Louf, Carmen Gallego
Publicado en: Molecular Pharmacology, 2019, Página(s) mol.118.115329, ISSN 0026-895X
Editor: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.118.115329

Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs

Autores: Timo W.M. De Groof, Vladimir Bobkov, Raimond Heukers, Martine J. Smit
Publicado en: Molecular and Cellular Endocrinology, Edición 484, 2019, Página(s) 15-24, ISSN 0303-7207
Editor: Elsevier BV
DOI: 10.1016/j.mce.2019.01.021

CXCR4/ACKR3 phosphorylation and recruitment of interacting proteins: key mechanisms regulating their functional status

Autores: Amos Fumagalli, Aurelien Zarca, Maria Neves, Birgit Caspar, Stephen J Hill, Federico Mayor, Martine J Smit, Philippe Marin
Publicado en: Molecular Pharmacology, 2019, Página(s) mol.118.115360, ISSN 0026-895X
Editor: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.118.115360

The role of ACKR3 in breast, lung and brain cancer.

Autores: Maria Neves, Amos Fumagalli, Jelle van den Bor, Philippe Marin, Martine J Smit, Federico Mayor
Publicado en: Molecular Pharmacology, 2019, Página(s) mol.118.115279, ISSN 0026-895X
Editor: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.118.115279

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists

Autores: I. Adlere, S. Sun, A. Zarca, L. Roumen, M. Gozelle, C. Perpiñá Viciano, B. Caspar, M. Arimont, J.P. Bebelman, S.J. Briddon, C. Hoffmann, S.J. Hill, M.J. Smit, H.F. Vischer, M. Wijtmans, C. de Graaf, I.J.P. de Esch, R. Leurs
Publicado en: European Journal of Medicinal Chemistry, Edición 162, 2019, Página(s) 631-649, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2018.10.060

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry

Autores: Anneleen Van Hout, Alex Klarenbeek, Vladimir Bobkov, Jordi Doijen, Marta Arimont, Chunxia Zhao, Raimond Heukers, Rebecca Rimkunas, Chris de Graaf, Theo Verrips, Bas van der Woning, Hans de Haard, Joseph B. Rucker, Kurt Vermeire, Tracy Handel, Tom Van Loy, Martine J. Smit, Dominique Schols
Publicado en: Biochemical Pharmacology, Edición 158, 2018, Página(s) 402-412, ISSN 0006-2952
Editor: Elsevier BV
DOI: 10.1016/j.bcp.2018.10.015

G protein-coupled receptor kinases (GRKs) in tumorigenesis and cancer progression: GPCR regulators and signaling hubs

Autores: Laura Nogués, Julia Palacios-García, Clara Reglero, Verónica Rivas, María Neves, Catalina Ribas, Petronila Penela, Federico Mayor
Publicado en: Seminars in Cancer Biology, Edición 48, 2018, Página(s) 78-90, ISSN 1044-579X
Editor: Academic Press
DOI: 10.1016/j.semcancer.2017.04.013

Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions

Autores: Vladimir Bobkov, Aurelien M. Zarca, Anneleen Van Hout, Marta Arimont, Jordi Doijen, Magdalena Bialkowska, Elisa Toffoli, Alex Klarenbeek, Bas van der Woning, Hans J. van der Vliet, Tom Van Loy, Hans de Haard, Dominique Schols, Raimond Heukers, Martine J. Smit
Publicado en: Biochemical Pharmacology, Edición 158, 2018, Página(s) 413-424, ISSN 0006-2952
Editor: Elsevier BV
DOI: 10.1016/j.bcp.2018.10.014

G-Protein–Coupled Receptor Kinase 2 as a Potential Modulator of the Hallmarks of Cancer

Autores: Laura Nogués, Clara Reglero, Verónica Rivas, María Neves, Petronila Penela, Federico Mayor
Publicado en: Molecular Pharmacology, Edición 91/3, 2017, Página(s) 220-228, ISSN 0026-895X
Editor: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.116.107185

DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops

Autores: Bas van der Woning, Gitte De Boeck, Christophe Blanchetot, Vladimir Bobkov, Alex Klarenbeek, Michael Saunders, Magali Waelbroeck, Toon Laeremans, Jan Steyaert, Anna Hultberg, Hans De Haard
Publicado en: mAbs, Edición 8/6, 2016, Página(s) 1126-1135, ISSN 1942-0870
Editor: Landes Bioscience
DOI: 10.1080/19420862.2016.1189050

CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome

Autores: Raymond H. de Wit, Raimond Heukers, Hendrik J. Brink, Angela Arsova, David Maussang, Pasquale Cutolo, Beatrijs Strubbe, Henry F. Vischer, Françoise Bachelerie, Martine J. Smit
Publicado en: Journal of Pharmacology and Experimental Therapeutics, Edición 363/1, 2017, Página(s) 35-44, ISSN 0022-3565
Editor: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/jpet.117.242735

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis

Autores: Laura Nogués, Clara Reglero, Verónica Rivas, Alicia Salcedo, Vanesa Lafarga, Maria Neves, Paula Ramos, Marta Mendiola, Alberto Berjón, Kostas Stamatakis, Xiao Zhen Zhou, Kun Ping Lu, David Hardisson, Federico Mayor, Petronila Penela
Publicado en: EBioMedicine, Edición 13, 2016, Página(s) 132-145, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2016.09.030

Peripheral Interaction of Resolvin D1 and E1 with Opioid Receptor Antagonists for Antinociception in Inflammatory Pain in Rats

Autores: Beatrice Oehler, Milad Mohammadi, Cristina Perpina Viciano, Dagmar Hackel, Carsten Hoffmann, Alexander Brack, Heike L. Rittner
Publicado en: Frontiers in Molecular Neuroscience, Edición 10, 2017, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2017.00242

Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Autores: Nikaïa Smith, Nicolas Pietrancosta, Sophia Davidson, Jacques Dutrieux, Lise Chauveau, Pasquale Cutolo, Michel Dy, Daniel Scott-Algara, Bénédicte Manoury, Onofrio Zirafi, Isabelle McCort-Tranchepain, Thierry Durroux, Françoise Bachelerie, Olivier Schwartz, Jan Münch, Andreas Wack, Sébastien Nisole, Jean-Philippe Herbeuval
Publicado en: Nature Communications, Edición 8/1, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms14253

Structural Analysis of Chemokine Receptor–Ligand Interactions

Autores: Marta Arimont, Shan-Liang Sun, Rob Leurs, Martine Smit, Iwan J. P. de Esch, Chris de Graaf
Publicado en: Journal of Medicinal Chemistry, Edición 60/12, 2017, Página(s) 4735-4779, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.6b01309