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ONCOgenic Receptor Network of Excellence and Training

Livrables

Draft Periodic Report

Compulsory deliverable

Mid-Term Review meeting

Compulsory deliverable

Progress Report

Compulsory deliverable

Ethics

Compulsory deliverable

ONCORNET website

ONCORNET website built and online wwwoncorneteu 2

Output

Abstracts for international conferences and publications submitted

Open meetings organized

Kick-off organised in conjunction with AIMMS-GPCR symposium (7) Final meeting organised

Supervisory board of Network

Compulsory deliverable

Publications

Molecular Pharmacology of Chemokine Receptors

Auteurs: Raymond H. de Wit, Sabrina M. de Munnik, Rob Leurs, Henry F. Vischer and Martine J. Smit
Publié dans: Methods in Enzymology, editor: Tracy M. Handel, Numéro 570, 2016, Page(s) 457-515, ISBN 978-0-12-802171-2
Éditeur: Academic Press
DOI: 10.1016/bs.mie.2015.12.002

Time-Resolved FRET-Based Assays to Characterize G Protein-Coupled Receptor Hetero-oligomer Pharmacology

Auteurs: Joyce Heuninck, Candide Hounsou, Elodie Dupuis, Eric Trinquet, Bernard Mouillac, Jean-Philippe Pin, Dominique Bonnet, Thierry Durroux
Publié dans: G Protein-Coupled Receptor Signaling - Methods and Protocols, Numéro 1947, 2019, Page(s) 151-168, ISBN 978-1-4939-9120-4
Éditeur: Springer New York
DOI: 10.1007/978-1-4939-9121-1_8

Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding

Auteurs: Orestis Faklaris, Joyce Heuninck, Amandine Falco, Elise Goyet, Jurriaan M. Zwier, Jean-Philippe Pin, Bernard Mouillac, Julie Perroy, Thierry Durroux
Publié dans: Topics in Medicinal Chemistry, 2017
Éditeur: Springer Berlin Heidelberg
DOI: 10.1007/7355_2017_2

Atypical chemokine receptor 3 (ACKR3): a comprehensive overview of its expression and potential roles in the immune system.

Auteurs: Joyce Koenen, Francoise Bachelerie, Karl Balabanian, Geraldine Schlecht-Louf, Carmen Gallego
Publié dans: Molecular Pharmacology, 2019, Page(s) mol.118.115329, ISSN 0026-895X
Éditeur: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.118.115329

Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs

Auteurs: Timo W.M. De Groof, Vladimir Bobkov, Raimond Heukers, Martine J. Smit
Publié dans: Molecular and Cellular Endocrinology, Numéro 484, 2019, Page(s) 15-24, ISSN 0303-7207
Éditeur: Elsevier BV
DOI: 10.1016/j.mce.2019.01.021

CXCR4/ACKR3 phosphorylation and recruitment of interacting proteins: key mechanisms regulating their functional status

Auteurs: Amos Fumagalli, Aurelien Zarca, Maria Neves, Birgit Caspar, Stephen J Hill, Federico Mayor, Martine J Smit, Philippe Marin
Publié dans: Molecular Pharmacology, 2019, Page(s) mol.118.115360, ISSN 0026-895X
Éditeur: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.118.115360

The role of ACKR3 in breast, lung and brain cancer.

Auteurs: Maria Neves, Amos Fumagalli, Jelle van den Bor, Philippe Marin, Martine J Smit, Federico Mayor
Publié dans: Molecular Pharmacology, 2019, Page(s) mol.118.115279, ISSN 0026-895X
Éditeur: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.118.115279

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists

Auteurs: I. Adlere, S. Sun, A. Zarca, L. Roumen, M. Gozelle, C. Perpiñá Viciano, B. Caspar, M. Arimont, J.P. Bebelman, S.J. Briddon, C. Hoffmann, S.J. Hill, M.J. Smit, H.F. Vischer, M. Wijtmans, C. de Graaf, I.J.P. de Esch, R. Leurs
Publié dans: European Journal of Medicinal Chemistry, Numéro 162, 2019, Page(s) 631-649, ISSN 0223-5234
Éditeur: Elsevier BV
DOI: 10.1016/j.ejmech.2018.10.060

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry

Auteurs: Anneleen Van Hout, Alex Klarenbeek, Vladimir Bobkov, Jordi Doijen, Marta Arimont, Chunxia Zhao, Raimond Heukers, Rebecca Rimkunas, Chris de Graaf, Theo Verrips, Bas van der Woning, Hans de Haard, Joseph B. Rucker, Kurt Vermeire, Tracy Handel, Tom Van Loy, Martine J. Smit, Dominique Schols
Publié dans: Biochemical Pharmacology, Numéro 158, 2018, Page(s) 402-412, ISSN 0006-2952
Éditeur: Elsevier BV
DOI: 10.1016/j.bcp.2018.10.015

G protein-coupled receptor kinases (GRKs) in tumorigenesis and cancer progression: GPCR regulators and signaling hubs

Auteurs: Laura Nogués, Julia Palacios-García, Clara Reglero, Verónica Rivas, María Neves, Catalina Ribas, Petronila Penela, Federico Mayor
Publié dans: Seminars in Cancer Biology, Numéro 48, 2018, Page(s) 78-90, ISSN 1044-579X
Éditeur: Academic Press
DOI: 10.1016/j.semcancer.2017.04.013

Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions

Auteurs: Vladimir Bobkov, Aurelien M. Zarca, Anneleen Van Hout, Marta Arimont, Jordi Doijen, Magdalena Bialkowska, Elisa Toffoli, Alex Klarenbeek, Bas van der Woning, Hans J. van der Vliet, Tom Van Loy, Hans de Haard, Dominique Schols, Raimond Heukers, Martine J. Smit
Publié dans: Biochemical Pharmacology, Numéro 158, 2018, Page(s) 413-424, ISSN 0006-2952
Éditeur: Elsevier BV
DOI: 10.1016/j.bcp.2018.10.014

G-Protein–Coupled Receptor Kinase 2 as a Potential Modulator of the Hallmarks of Cancer

Auteurs: Laura Nogués, Clara Reglero, Verónica Rivas, María Neves, Petronila Penela, Federico Mayor
Publié dans: Molecular Pharmacology, Numéro 91/3, 2017, Page(s) 220-228, ISSN 0026-895X
Éditeur: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.116.107185

DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops

Auteurs: Bas van der Woning, Gitte De Boeck, Christophe Blanchetot, Vladimir Bobkov, Alex Klarenbeek, Michael Saunders, Magali Waelbroeck, Toon Laeremans, Jan Steyaert, Anna Hultberg, Hans De Haard
Publié dans: mAbs, Numéro 8/6, 2016, Page(s) 1126-1135, ISSN 1942-0870
Éditeur: Landes Bioscience
DOI: 10.1080/19420862.2016.1189050

CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome

Auteurs: Raymond H. de Wit, Raimond Heukers, Hendrik J. Brink, Angela Arsova, David Maussang, Pasquale Cutolo, Beatrijs Strubbe, Henry F. Vischer, Françoise Bachelerie, Martine J. Smit
Publié dans: Journal of Pharmacology and Experimental Therapeutics, Numéro 363/1, 2017, Page(s) 35-44, ISSN 0022-3565
Éditeur: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/jpet.117.242735

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis

Auteurs: Laura Nogués, Clara Reglero, Verónica Rivas, Alicia Salcedo, Vanesa Lafarga, Maria Neves, Paula Ramos, Marta Mendiola, Alberto Berjón, Kostas Stamatakis, Xiao Zhen Zhou, Kun Ping Lu, David Hardisson, Federico Mayor, Petronila Penela
Publié dans: EBioMedicine, Numéro 13, 2016, Page(s) 132-145, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2016.09.030

Peripheral Interaction of Resolvin D1 and E1 with Opioid Receptor Antagonists for Antinociception in Inflammatory Pain in Rats

Auteurs: Beatrice Oehler, Milad Mohammadi, Cristina Perpina Viciano, Dagmar Hackel, Carsten Hoffmann, Alexander Brack, Heike L. Rittner
Publié dans: Frontiers in Molecular Neuroscience, Numéro 10, 2017, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnmol.2017.00242

Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Auteurs: Nikaïa Smith, Nicolas Pietrancosta, Sophia Davidson, Jacques Dutrieux, Lise Chauveau, Pasquale Cutolo, Michel Dy, Daniel Scott-Algara, Bénédicte Manoury, Onofrio Zirafi, Isabelle McCort-Tranchepain, Thierry Durroux, Françoise Bachelerie, Olivier Schwartz, Jan Münch, Andreas Wack, Sébastien Nisole, Jean-Philippe Herbeuval
Publié dans: Nature Communications, Numéro 8/1, 2017, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/ncomms14253

Structural Analysis of Chemokine Receptor–Ligand Interactions

Auteurs: Marta Arimont, Shan-Liang Sun, Rob Leurs, Martine Smit, Iwan J. P. de Esch, Chris de Graaf
Publié dans: Journal of Medicinal Chemistry, Numéro 60/12, 2017, Page(s) 4735-4779, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.6b01309

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