ONCOgenic Receptor Network of Excellence and Training

Risultati finali

Draft Periodic Report

Compulsory deliverable

Mid-Term Review meeting

Compulsory deliverable

Progress Report

Compulsory deliverable

Ethics

Compulsory deliverable

ONCORNET website

ONCORNET website built and online wwwoncorneteu 2

Output

Abstracts for international conferences and publications submitted

Open meetings organized

Kick-off organised in conjunction with AIMMS-GPCR symposium (7) Final meeting organised

Supervisory board of Network

Compulsory deliverable

Pubblicazioni

Molecular Pharmacology of Chemokine Receptors

Autori: Raymond H. de Wit, Sabrina M. de Munnik, Rob Leurs, Henry F. Vischer and Martine J. Smit
Pubblicato in: Methods in Enzymology, editor: Tracy M. Handel, Numero 570, 2016, Pagina/e 457-515, ISBN 978-0-12-802171-2
Editore: Academic Press
DOI: 10.1016/bs.mie.2015.12.002

Time-Resolved FRET-Based Assays to Characterize G Protein-Coupled Receptor Hetero-oligomer Pharmacology

Autori: Joyce Heuninck, Candide Hounsou, Elodie Dupuis, Eric Trinquet, Bernard Mouillac, Jean-Philippe Pin, Dominique Bonnet, Thierry Durroux
Pubblicato in: G Protein-Coupled Receptor Signaling - Methods and Protocols, Numero 1947, 2019, Pagina/e 151-168, ISBN 978-1-4939-9120-4
Editore: Springer New York
DOI: 10.1007/978-1-4939-9121-1_8

Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding

Autori: Orestis Faklaris, Joyce Heuninck, Amandine Falco, Elise Goyet, Jurriaan M. Zwier, Jean-Philippe Pin, Bernard Mouillac, Julie Perroy, Thierry Durroux
Pubblicato in: Topics in Medicinal Chemistry, 2017
Editore: Springer Berlin Heidelberg
DOI: 10.1007/7355_2017_2

Atypical chemokine receptor 3 (ACKR3): a comprehensive overview of its expression and potential roles in the immune system.

Autori: Joyce Koenen, Francoise Bachelerie, Karl Balabanian, Geraldine Schlecht-Louf, Carmen Gallego
Pubblicato in: Molecular Pharmacology, 2019, Pagina/e mol.118.115329, ISSN 0026-895X
Editore: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.118.115329

Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs

Autori: Timo W.M. De Groof, Vladimir Bobkov, Raimond Heukers, Martine J. Smit
Pubblicato in: Molecular and Cellular Endocrinology, Numero 484, 2019, Pagina/e 15-24, ISSN 0303-7207
Editore: Elsevier BV
DOI: 10.1016/j.mce.2019.01.021

CXCR4/ACKR3 phosphorylation and recruitment of interacting proteins: key mechanisms regulating their functional status

Autori: Amos Fumagalli, Aurelien Zarca, Maria Neves, Birgit Caspar, Stephen J Hill, Federico Mayor, Martine J Smit, Philippe Marin
Pubblicato in: Molecular Pharmacology, 2019, Pagina/e mol.118.115360, ISSN 0026-895X
Editore: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.118.115360

The role of ACKR3 in breast, lung and brain cancer.

Autori: Maria Neves, Amos Fumagalli, Jelle van den Bor, Philippe Marin, Martine J Smit, Federico Mayor
Pubblicato in: Molecular Pharmacology, 2019, Pagina/e mol.118.115279, ISSN 0026-895X
Editore: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.118.115279

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists

Autori: I. Adlere, S. Sun, A. Zarca, L. Roumen, M. Gozelle, C. Perpiñá Viciano, B. Caspar, M. Arimont, J.P. Bebelman, S.J. Briddon, C. Hoffmann, S.J. Hill, M.J. Smit, H.F. Vischer, M. Wijtmans, C. de Graaf, I.J.P. de Esch, R. Leurs
Pubblicato in: European Journal of Medicinal Chemistry, Numero 162, 2019, Pagina/e 631-649, ISSN 0223-5234
Editore: Elsevier BV
DOI: 10.1016/j.ejmech.2018.10.060

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry

Autori: Anneleen Van Hout, Alex Klarenbeek, Vladimir Bobkov, Jordi Doijen, Marta Arimont, Chunxia Zhao, Raimond Heukers, Rebecca Rimkunas, Chris de Graaf, Theo Verrips, Bas van der Woning, Hans de Haard, Joseph B. Rucker, Kurt Vermeire, Tracy Handel, Tom Van Loy, Martine J. Smit, Dominique Schols
Pubblicato in: Biochemical Pharmacology, Numero 158, 2018, Pagina/e 402-412, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2018.10.015

G protein-coupled receptor kinases (GRKs) in tumorigenesis and cancer progression: GPCR regulators and signaling hubs

Autori: Laura Nogués, Julia Palacios-García, Clara Reglero, Verónica Rivas, María Neves, Catalina Ribas, Petronila Penela, Federico Mayor
Pubblicato in: Seminars in Cancer Biology, Numero 48, 2018, Pagina/e 78-90, ISSN 1044-579X
Editore: Academic Press
DOI: 10.1016/j.semcancer.2017.04.013

Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions

Autori: Vladimir Bobkov, Aurelien M. Zarca, Anneleen Van Hout, Marta Arimont, Jordi Doijen, Magdalena Bialkowska, Elisa Toffoli, Alex Klarenbeek, Bas van der Woning, Hans J. van der Vliet, Tom Van Loy, Hans de Haard, Dominique Schols, Raimond Heukers, Martine J. Smit
Pubblicato in: Biochemical Pharmacology, Numero 158, 2018, Pagina/e 413-424, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2018.10.014

G-Protein–Coupled Receptor Kinase 2 as a Potential Modulator of the Hallmarks of Cancer

Autori: Laura Nogués, Clara Reglero, Verónica Rivas, María Neves, Petronila Penela, Federico Mayor
Pubblicato in: Molecular Pharmacology, Numero 91/3, 2017, Pagina/e 220-228, ISSN 0026-895X
Editore: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.116.107185

DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops

Autori: Bas van der Woning, Gitte De Boeck, Christophe Blanchetot, Vladimir Bobkov, Alex Klarenbeek, Michael Saunders, Magali Waelbroeck, Toon Laeremans, Jan Steyaert, Anna Hultberg, Hans De Haard
Pubblicato in: mAbs, Numero 8/6, 2016, Pagina/e 1126-1135, ISSN 1942-0870
Editore: Landes Bioscience
DOI: 10.1080/19420862.2016.1189050

CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome

Autori: Raymond H. de Wit, Raimond Heukers, Hendrik J. Brink, Angela Arsova, David Maussang, Pasquale Cutolo, Beatrijs Strubbe, Henry F. Vischer, Françoise Bachelerie, Martine J. Smit
Pubblicato in: Journal of Pharmacology and Experimental Therapeutics, Numero 363/1, 2017, Pagina/e 35-44, ISSN 0022-3565
Editore: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/jpet.117.242735

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis

Autori: Laura Nogués, Clara Reglero, Verónica Rivas, Alicia Salcedo, Vanesa Lafarga, Maria Neves, Paula Ramos, Marta Mendiola, Alberto Berjón, Kostas Stamatakis, Xiao Zhen Zhou, Kun Ping Lu, David Hardisson, Federico Mayor, Petronila Penela
Pubblicato in: EBioMedicine, Numero 13, 2016, Pagina/e 132-145, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2016.09.030

Peripheral Interaction of Resolvin D1 and E1 with Opioid Receptor Antagonists for Antinociception in Inflammatory Pain in Rats

Autori: Beatrice Oehler, Milad Mohammadi, Cristina Perpina Viciano, Dagmar Hackel, Carsten Hoffmann, Alexander Brack, Heike L. Rittner
Pubblicato in: Frontiers in Molecular Neuroscience, Numero 10, 2017, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2017.00242

Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Autori: Nikaïa Smith, Nicolas Pietrancosta, Sophia Davidson, Jacques Dutrieux, Lise Chauveau, Pasquale Cutolo, Michel Dy, Daniel Scott-Algara, Bénédicte Manoury, Onofrio Zirafi, Isabelle McCort-Tranchepain, Thierry Durroux, Françoise Bachelerie, Olivier Schwartz, Jan Münch, Andreas Wack, Sébastien Nisole, Jean-Philippe Herbeuval
Pubblicato in: Nature Communications, Numero 8/1, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms14253

Structural Analysis of Chemokine Receptor–Ligand Interactions

Autori: Marta Arimont, Shan-Liang Sun, Rob Leurs, Martine Smit, Iwan J. P. de Esch, Chris de Graaf
Pubblicato in: Journal of Medicinal Chemistry, Numero 60/12, 2017, Pagina/e 4735-4779, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.6b01309

Risultati finali

Pubblicazioni

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